Treatment of murine lupus with monoclonal antibody to L3T4. I. Effects on the distribution and function of lymphocyte subsets and on the histopathology of autoimmune disease

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype Antibody

1982 • 1,001 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal Transplants

1985 • 697 citations

Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice.

1978 • 637 citations

PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NZB/W MICE

1968 • 622 citations

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.

1980 • 574 citations

Defective Reticuloendothelial System Fc-Receptor Function in Systemic Lupus Erythematosus

1979 • 535 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.

1985 • 466 citations

A clinical trial of anti-idiotype therapy for B cell malignancy

1985 • 434 citations

Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.

1985 • 372 citations

Immunotherapy of the Nonobese Diabetic Mouse: Treatment with an Antibody to T-Helper Lymphocytes

1988 • 351 citations

Reversal of Experimental Allergic Encephalomyelitis with Monoclonal Antibody to a T-Cell Subset Marker

1985 • 328 citations

Induction of tolerance by monoclonal antibody therapy

1986 • 307 citations

Emergence of Idiotype Variants during Treatment of B-Cell Lymphoma with Anti-Idiotype Antibodies

1985 • 257 citations

Monoclonal Antibodies Against Rat Immunoglobulin Kappa Chains

1982 • 257 citations

Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice

1987 • 216 citations

Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4.

1987 • 211 citations

Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.

1983 • 208 citations

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.

1985 • 191 citations

Monoclonal Antibodies

1980 • 189 citations

Treatment of murine lupus with monoclonal anti-T cell antibody.

1985 • 186 citations

Suppression of murine lupus nephritis by administration of an anti-idiotypic antibody to anti-DNA.

1984 • 176 citations

Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes.

1979 • 167 citations

A laboratory model for Sjögren's syndrome.

1968 • 145 citations

Textbook of Immunopathology

1977 • 133 citations

The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens.

1984 • 128 citations

Induction of immune tolerance by administration of monoclonal antibody to L3T4.

1986 • 127 citations

Immunotherapy for myasthenia gravis: a murine model.

1986 • 125 citations

Selective Loss of Suppressor Cell Function in New Zealand Mice Induced by NTA

1977 • 121 citations

Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: studies with soluble antigens in intact mice.

1985 • 116 citations

Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4.

1986 • 115 citations

Tumor therapy with monoclonal antibodies.

1983 • 113 citations

Differential Cytotoxic Effect of Natural Thymocytotoxic Autoantibody of NZB Mice on Functional Subsets of T Cells

1978 • 107 citations

Bronchus-Associated Lymphoid Tissue

1985 • 106 citations

Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice

1987 • 96 citations

Administration of monoclonal anti-T cell antibodies retards murine lupus in BXSB mice.

1986 • 95 citations

Depletion of T-4+ lymphocytes with monoclonal antibody reactivates toxoplasmosis in the central nervous system: a model of superinfection in AIDS.

1987 • 83 citations

Sjögren's Syndrome: A Defect in Reticuloendothelial System Fc-Receptor-Specific Clearance

1979 • 83 citations

Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.

1983 • 76 citations

Development of CD4−CD8+ cytotoxic T cells requires interactions with class I MHC determinants

1988 • 76 citations

Administration of F(ab')2 fragments of monoclonal antibody to L3T4 inhibits humoral immunity in mice without depleting L3T4+ cells.

1986 • 67 citations

In vivo suppression of T‐dependent antibody responses by treatment with a monoclonal anti‐L3T4 antibody

1985 • 57 citations

Thymus-antigen- and immunoglobulin-positive lymphocytes in tissue infiltrates of NZB/NZW mice

1974 • 46 citations

Clearance of sensitized erythrocytes in NZB/NZW mice Effects of castration and sex hormone treatment

1981 • 43 citations

Immunohistochemical characterization of sialadenitis in NZB × NZW F1 mice

1987 • 41 citations

HLA-Dr+ T cells of the Leu 3 (helper) type infiltrate the kidneys of patients with systemic lupus erythematosus.

1985 • 41 citations

Subepidermal Deposition of Immunoglobulin in NZB/NZW F1 Hybrid Mice

1975 • 40 citations

Effects of castration and sex hormones on immune clearance and autoimmune disease in and mice

1983 • 36 citations

The T4 molecule: function and structure

1986 • 34 citations

Strategies for treating autoimmune disease with monoclonal antibodies.

1985 • 27 citations

REJECTION OF SKIN GRAFTS AND GENERATION OF CYTOTOXIC T CELLS BY MICE DEPLETED OF L3T4+ CELLS

1986 • 22 citations

Murine T-Cell Differentiation Antigens Detected by Monoclonal Antibodies

1980 • 15 citations

Monoclonal antibodies--therapeutic and diagnostic uses in malignancy.

1985 • 13 citations

CD 4-/CD 8- T cells: amplification in spleens of mice following in vivo treatment with monoclonal antibody anti-L3T4

1988 • 11 citations

1.2. Monoclonal antibodies

1983 • 4 citations