Analysis of Expression Profiles of Islet-associated Transcription and Growth Factors During β-Cell Neogenesis from Duct Cells in Partially Duct-ligated Mice

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

2000 • 1,416 citations

Notch signalling controls pancreatic cell differentiation

1999 • 1,147 citations

Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells

2000 • 1,132 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

2001 • 788 citations

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1997 • 776 citations

PGP 9.5—a new marker for vertebrate neurons and neuroendocrine cells

1983 • 712 citations

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

1997 • 690 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

1986 • 570 citations

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 • 551 citations

Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo

1991 • 499 citations

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

2000 • 443 citations

Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats

1995 • 435 citations

Effects of growth factors on an intestinal epithelial cell line: Transforming growth factor β inhibits proliferation and stimulates differentiation

1987 • 305 citations

Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells.

1996 • 279 citations

Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.

1993 • 272 citations

The Physiology Of Transforming Growth Factor-α

1992 • 257 citations

Gastrin Stimulates β-Cell Neogenesis and Increases Islet Mass From Transdifferentiated but Not From Normal Exocrine Pancreas Tissue

2002 • 253 citations

Insulin-like Growth Factor I (IGF-I)-stimulated Pancreatic β-Cell Growth Is Glucose-dependent

1998 • 248 citations

Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.

1992 • 223 citations

Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro

2000 • 198 citations

TGF-β Plays a Key Role in Morphogenesis of the Pancreatic Islets of Langerhans by Controlling the Activity of the Matrix Metalloproteinase MMP-2

1998 • 174 citations

Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas.

1991 • 122 citations

Insulin-Like Growth Factor Gene Expression during Rat Embryonic Development*

1987 • 118 citations

A Role for Activin A and Betacellulin in Human Fetal Pancreatic Cell Differentiation and Growth1

2000 • 108 citations

PDX-1 and Msx-2 expression in the regenerating and developing pancreas

1999 • 98 citations

Expression of gastrin and transforming growth factor-α during duct to islet cell differentiation in the pancreas of duct-ligated adult rats

1997 • 91 citations

Demonstration of Two Different Processes of β-Cell Regeneration in a New Diabetic Mouse Model Induced by Selective Perfusion of Alloxan

1997 • 84 citations

Changes in the Mouse Exocrine Pancreas after Pancreatic Duct Ligation: A Qualitative and Quantitative Histological Study.

1995 • 80 citations

Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor during Pancreas Development

1997 • 71 citations

Expression of Immunoreactive Activin A in Fetal Rat Pancreas.

1995 • 65 citations

p53-Dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas

2000 • 64 citations

Immunohistochemical Localization of Betacellulin, a New Member of the EGF Family, in Normal Human Pancreas and Islet Tumor Cells.

1999 • 62 citations

Existence of activin-A in A- and D-cells of rat pancreatic islet.

1993 • 60 citations

The immunolocalisation of the neuroendocrine specific protein PGP9.5 during neurogenesis in the rat

1991 • 54 citations

Transcription factor expression during pancreatic islet regeneration

2000 • 53 citations

Processing and juxtacrine activity of membrane-anchored betacellulin

1999 • 51 citations

Somatomedin-C in Human Fetal Pancreas: Cellular Localization and Release During Organ Culture

1987 • 50 citations

Changes in the expression of transcription factors in pancreatic AR42J cells during differentiation into insulin-producing cells.

2001 • 50 citations

Transforming growth factor-alpha (TGF-α) and insulin gene expression in human fetal pancreas

1992 • 50 citations

THE INSULIN-LIKE GROWTH FACTOR I (IGF-I) GENE IS EXPRESSED IN CHICK EMBRYOS DURING EARLY ORGANOGENESIS

1990 • 50 citations

A Role for Activin A and Betacellulin in Human Fetal Pancreatic Cell Differentiation and Growth

2000 • 50 citations

Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats

2001 • 45 citations

Transforming growth factor-β1 in the developing mouse pancreas: a potential regulator of exocrine differentiation

2000 • 44 citations

The ontogeny of TGF-β1, -β2, -β3, and TGF-β receptor-II expression in the pancreas: Implications for regulation of growth and differentiation

1999 • 39 citations

Existence of activin-A in A- and D-cells of rat pancreatic islet

1993 • 27 citations

Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan

1997 • 27 citations

Somatomedin-C in human fetal pancreas. Cellular localization and release during organ culture

1987 • 26 citations

Expression of PGP9.5 in Ductal Cells of the Rat Pancreas during Development and Regeneration: Can It Be a Marker for Pancreatic Progenitor Cells?

2002 • 24 citations

Insulin-like growth factor-I-induced DNA synthesis in insulin-secreting cell line RINm5F is associated with phosphorylation of the insulin-like growth factor-I receptor and the insulin receptor substrate-2

1998 • 16 citations

IFN-?? Overexpression Within the Pancreas Is Not Sufficient to Rescue Pax4, Pax6, and Pdx-1 Mutant Mice from Death

2000 • 6 citations