Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic .beta.-protein fragments

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Vibrational Spectroscopy and Conformation of Peptides, Polypeptides, and Proteins

1986 • 2,761 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Structure and Reactivity of Lithium Enolates. From Pinacolone to Selective C‐Alkylations of Peptides. Difficulties and Opportunities Afforded by Complex Structures

1988 • 803 citations

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.

1986 • 553 citations

Secondary Structure of Proteins Through Circular Dichroism Spectroscopy

1988 • 537 citations

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

1987 • 475 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

“Cross-β” conformation in proteins

1968 • 392 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

Differences Between Vascular and Plaque Core Amyloid in Alzheimer's Disease

1988 • 348 citations

β-PLEATED SHEET FIBRILS A COMPARISON OF NATIVE AMYLOID WITH SYNTHETIC PROTEIN FIBRILS

1974 • 294 citations

Mechanisms for the removal of benzyl protecting groups in synthetic peptides by trifluoromethanesulfonic acid-trifluoroacetic acid-dimethyl sulfide

1986 • 281 citations

Formation of recombinant protein inclusion bodies in Escherichia coli

1988 • 253 citations

In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to alzheimer's disease β-protein

1986 • 226 citations

Human amyloidosis, Alzheimer disease and related disorders.

1988 • 177 citations

Protein chemical and immunocytochemical studies of meningovascular β-amyloid protein in Alzheimer's disease and normal aging

1988 • 173 citations

Ten to fourteen residue peptides of Alzheimer's disease protein are sufficient for amyloid fibril formation and its characteristic xray diffraction pattern

1987 • 154 citations

Three types of amyloid protein precursor mRNA in human brain: Their differential expression in Alzheimer's disease

1988 • 150 citations

Alzheimer's disease: Its proteins and genes

1988 • 149 citations

Solid-phase synthesis of protected peptides on a polymer-bound oxime: preparation of segments comprising the sequence of a cytotoxic 26-peptide analog

1982 • 145 citations

Peptide and Protein Synthesis by Segment Synthesis-Condensation

1989 • 117 citations

The structure of tussah silk fibroin (with a note on the structure of β-poly-<scp>L</scp>-alanine)

1955 • 102 citations

Solubilization of Peptides in Non‐polar Organic Solvents by the Addition of Inorganic Salts: Facts and Implications

1989 • 87 citations

Synthesis of protected peptide segments and their assembly on a polymer-bound oxime: application to the synthesis of a peptide model for plasma apolipoprotein A-I

1983 • 73 citations

Prediction and improvement of protected peptide solubility in organic solvents*

1984 • 73 citations

Enter a protease inhibitor

1988 • 62 citations

Synthetic approaches to biologically active peptides and proteins including enzymes

1989 • 59 citations

Infrared spectroscopy of human amyloid fibrils and immunogolbulin proteins

1972 • 57 citations

The structure of β-keratin

1969 • 56 citations

Synthesis and structural investigation of poly(l-alanyl-l-alanyl-glycine)

1970 • 55 citations

The Solubility of Peptide Intermediates in Organic Solvents. Solubilizing Potential of Hexafluoro-2-propanol

1988 • 53 citations

Structure-function relationships in the inorganic salt-induced precipitation of α-chymotrypsin

1989 • 48 citations

Conformational properties of <scp>L</scp>‐leucine, <scp>L</scp>‐isoleucine, and <scp>L</scp>‐norleucine side chains in <scp>L</scp>‐lysine copolymers

1977 • 42 citations

Precipitates with β‐Pleated Sheet Structure by Mixing Aqueous Solutions of Helical Poly(<scp>D</scp>‐lysine) and Poly(<scp>L</scp>‐lysine)

1987 • 35 citations

Is amyloid deposition in Alzheimer's disease preceded by an environment-induced double conformational transition?

1989 • 30 citations

Nitrobenzophenone oxime based resins for the solid-phase synthesis of protected peptide segments

1989 • 26 citations

Individuality of Amino Acid Residues in Protected Peptides. Conformational and β-Sheet Structure-Disrupted Behaviors of Resin-Bound Peptides

1989 • 21 citations