Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll motif.

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

Using known substructures in protein model building and crystallography.

1986 • 766 citations

Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis.

1988 • 436 citations

Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases

1992 • 319 citations

The secreted hemolysins of Proteus mirabilis, Proteus vulgaris, and Morganella morganii are genetically related to each other and to the alpha-hemolysin of Escherichia coli

1987 • 228 citations

The repeat domain of Escherichia coli haemolysin (HlyA) is responsible for its Ca2+-dependent binding to erythrocytes

1988 • 191 citations

Cloning and sequencing ofSerratiaprotease gene

1986 • 184 citations

The Rhizobium nodulation gene nodO encodes a Ca2(+)-binding protein that is exported without N-terminal cleavage and is homologous to haemolysin and related proteins.

1990 • 177 citations

Effect of Pseudomonas aeruginosa elastase and alkaline protease on serum complement and isolated components C1q and C3

1992 • 162 citations

Sequence of a cluster of genes controlling synthesis and secretion of alkaline protease in Pseudomonas aeruginosa: relationships to other secretory pathways

1992 • 161 citations

Protease Secretion by Erwinia chrysanthemi

1989 • 142 citations

Refined 1·8 Å X-ray Crystal Structure of Astacin, a Zinc-endopeptidase from the Crayfish Astacus astacus L.

1993 • 138 citations

Extensive homology between the leukotoxin of Pasteurella haemolytica A1 and the alpha-hemolysin of Escherichia coli

1987 • 122 citations

The secretion genes of Pseudomonas aeruginosa alkaline protease are functionally related to those of Erwinia chrysanthemi proteases and Escherichia coliα‐haemolysin

1991 • 120 citations

Mutational analysis supports a role for multiple structural features in the C‐terminal secretion signal of Escherichia coli haemolysin

1991 • 117 citations

Identification of two different hemolysin determinants in uropathogenic Proteus isolates

1987 • 110 citations

Pseudomonas aeruginosa alkaline protease degrades human gamma interferon and inhibits its bioactivity

1988 • 95 citations

Cloning of genes encoding extracellular metalloproteases from Erwinia chrysanthemi EC16

1990 • 71 citations

Complete nucleotide sequence of the structural gene for alkaline proteinase from Pseudomonas aeruginosa IFO 3455

1990 • 58 citations