Induction of M-Phase Arrest and Apoptosis after HIV-1 Vpr Expression through Uncoupling of Nuclear and Centrosomal Cycle in HeLa Cells

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

1995 • 1,252 citations

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

1995 • 885 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1995 • 518 citations

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo

1998 • 506 citations

Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts

1999 • 505 citations

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.

1995 • 436 citations

Cyclin-dependent kinase control of centrosome duplication

1999 • 423 citations

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection

1995 • 411 citations

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

1995 • 382 citations

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis

1993 • 368 citations

Human immunodeficiency virus vpr product is a virion-associated regulatory protein

1990 • 363 citations

Centrioles in the cell cycle. I. Epithelial cells.

1982 • 362 citations

Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest

1997 • 348 citations

THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS

1968 • 316 citations

Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells.

1995 • 301 citations

Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions

1993 • 275 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1

1995 • 263 citations

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr

1995 • 260 citations

Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control

1996 • 253 citations

Identification of HIV-1 vpr product and function.

1990 • 251 citations

Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 Isolate

1994 • 237 citations

Induction of cell differentiation by human immunodeficiency virus 1 vpr

1993 • 214 citations

Mutational analysis of the human immunodeficiency virus vpr open reading frame

1989 • 183 citations

Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr

1997 • 179 citations

Interaction of Virion Protein Vpr of Human Immunodeficiency Virus Type 1 with Cellular Transcription Factor Sp1 and trans-Activation of Viral Long Terminal Repeat

1995 • 176 citations

Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme

1996 • 173 citations

Vpr Stimulates Viral Expression and Induces Cell Killing in Human Immunodeficiency Virus Type 1-Infected Dividing Jurkat T Cells

1998 • 168 citations

The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles

1995 • 164 citations

The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.

1990 • 159 citations

Human Immunodeficiency Virus: The Eighth Gene

1987 • 143 citations

A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles

1995 • 136 citations

Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr

1998 • 127 citations

Human Immunodeficiency VirusvprGene Encodes a Virion-Associated Protein

1990 • 126 citations

Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors.

1995 • 123 citations

Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest

1997 • 120 citations

Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants

1992 • 117 citations

The Human Immunodeficiency Virus Type 1 Vpr Transactivator: Cooperation with Promoter-bound Activator Domains and Binding to TFIIB

1996 • 117 citations

Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles

1994 • 113 citations

Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages

1993 • 101 citations

Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1.

1996 • 95 citations

Primary human immunodeficiency virus type 1 viremia and central nervous system invasion in a novel hu-PBL-immunodeficient mouse strain

1997 • 95 citations

Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair

1997 • 94 citations

Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein

1990 • 94 citations

Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome

1998 • 87 citations

Identification of Residues in the N-Terminal Acidic Domain of HIV-1 Vpr Essential for Virion Incorporation

1995 • 83 citations

Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard

1997 • 80 citations

Human immunodeficiency virus type 1 has an additional coding sequence in the central region of the genome.

1988 • 71 citations

Roles of p53 and Caspases in the Induction of Cell Cycle Arrest and Apoptosis by HIV-1 vpr

1999 • 70 citations

Role of γ-tubulin in mitosis-specific microtubule nucleation from the schizosaccharomyces pombe spindle pole body

1996 • 33 citations

Human Immunodeficiency Virus Type 1VprGene Product Prevents Cell Proliferation on Mouse NIH3T3 Cells without the G2Arrest of the Cell Cycle

1997 • 31 citations

Vectors for Expression and Amplification of cDNA in Mammalian Cells: Expression of Rat Phenylalanine Hydroxylase

1986 • 21 citations