The Phosphatidylinositol 3‐Kinase Inhibitor Wortmannin Alters the Metabolism of the Alzheimer's Amyloid Precursor Protein

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

1999 • 362 citations

Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells

1996 • 308 citations

Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1997 • 271 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

Phosphoinositide 3-Kinases and Their FYVE Domain-containing Effectors as Regulators of Vacuolar/Lysosomal Membrane Trafficking Pathways

1999 • 237 citations

Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes.

1995 • 202 citations

Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein

1994 • 175 citations

Regulated Formation of Golgi Secretory Vesicles Containing Alzheimer β-Amyloid Precursor Protein

1995 • 165 citations

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

1992 • 147 citations

Enhanced Release of Amyloid -Protein from Codon 670/671 Swedish Mutant -Amyloid Precursor Protein Occurs in Both Secretory and Endocytic Pathways

1996 • 129 citations

Phosphatidylinositol 3–Kinase Is Required for the Formation of Constitutive Transport Vesicles from the TGN

1997 • 84 citations

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.

1996 • 82 citations

Neurohormonal Signaling Pathways and the Regulation of Alzheimer β-Amyloid Precursor Metabolism

1999 • 34 citations