Evidence for distinct membrane receptors for 1α,25-(OH)2D3 and 24R,25-(OH)2D3 in osteoblasts

Vitamin D

1979 • 3,814 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

1,25-Dihydroxyvitamin D ₃ Receptors in Human Leukocytes

1983 • 1,030 citations

Protein kinase C

1991 • 914 citations

Induction of Rapid Osteoblast Differentiation in Rat Bone Marrow Stromal Cell Cultures by Dexamethasone and BMP-2

1994 • 533 citations

Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages

1998 • 379 citations

Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts

1994 • 328 citations

Deficient Mineralization of Intramembranous Bone in Vitamin D-24-Hydroxylase-Ablated Mice Is Due to Elevated 1,25-Dihydroxyvitamin D and Not to the Absence of 24,25-Dihydroxyvitamin D*

2000 • 321 citations

Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia.

1994 • 310 citations

Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2

1997 • 255 citations

Effects of vitamin D3 metabolites on cytosolic free calcium in confluent mouse osteoblasts.

1987 • 246 citations

Vitamin D3 Metabolites Modulate Dihydropyridine-sensitive Calcium Currents in Clonal Rat Osteosarcoma Cells

1989 • 241 citations

Gene expression in osteoblastic cells.

1991 • 228 citations

Bone Morphogenetic Protein 2 (BMP-2) Enhances BMP-3, BMP-4, and Bone Cell Differentiation Marker Gene Expression During the Induction of Mineralized Bone Matrix Formation in Culturesof Fetal Rat Calvarial Osteoblasts

1997 • 228 citations

Identification of a Membrane Receptor for 1,25-Dihydroxyvitamin D3 Which Mediates Rapid Activation of Protein Kinase C

1998 • 218 citations

Receptor-ligand interactions; a practical approach

1993 • 200 citations

Effects of combining transforming growth factor beta and 1,25-dihydroxyvitamin D3 on differentiation of a human osteosarcoma (MG-63).

1992 • 185 citations

1α, 25‐Dihydroxyvitamin D₃ specific regulation of growth, morphology, and fibronectin in a human osteosarcoma cell line

1985 • 183 citations

Nongenomic Activation of the Calcium Message System by Vitamin D Metabolites in Osteoblast-like Cells

1990 • 179 citations

Regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D3 in human osteosarcoma cells.

1988 • 154 citations

Localization of 1,25-(OH)2D3-responsive alkaline phosphatase in osteoblast-like cells (ROS 17/2.8, MG 63, and MC 3T3) and growth cartilage cells in culture

1989 • 150 citations

Lipid Mediators and Protein Kinase C Activation for the Intracellular Signaling Network

1994 • 133 citations

Nongenomic Actions of 1,25-Dihydroxyvitamin D₃in Rat Osteosarcoma Cells: Structure-Function Studies Using Ligand Analogs*

1991 • 126 citations

Comparison of 6-s-cis- and 6-s-trans-Locked Analogs of 1α,25-Dihydroxyvitamin D3 Indicates That the 6-s-cis Conformation Is Preferred for Rapid Nongenomic Biological Responses and That Neither 6-s-cis- nor 6-s-trans-Locked Analogs Are Preferred for Genomic Biological Responses

1997 • 121 citations

Nongenomic regulation of protein kinase C isoforms by the vitamin D metabolites 1α,25-(OH)2D3 and 24R,25-(OH)2D3

1996 • 104 citations

Maturation‐dependent regulation of protein kinase C activity by vitamin D₃ metabolites in chondrocyte cultures

1993 • 103 citations

[25] Mixed micelle assay of protein kinase C

1986 • 102 citations

Stimulation by 1α,25(OH)2-Vitamin D3 of Whole Cell Chloride Currents in Osteoblastic ROS 17/2.8 Cells

1997 • 100 citations

Targeted inactivation of vitamin D hydroxylases in mice

1999 • 100 citations

Physiological Importance of the 1,25(OH)2D3 Membrane Receptor and Evidence for a Membrane Receptor Specific for 24,25(OH)2D3

1999 • 97 citations

Intranuclear localization and receptor proteins for 1,25-dihydroxycholecalciferol in chick intestine

1974 • 97 citations

Immortalized murine osteoblasts derived from BMP 2-T-antigen expressing transgenic mice.

1996 • 95 citations

1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2

1999 • 91 citations

Annexin II is the membrane receptor that mediates the rapid actions of 1?,25-dihydroxyvitamin D3

2000 • 90 citations

Surface roughness modulates the response of MG63 osteoblast-like cells to 1,25-(OH)2D3 through regulation of phospholipase A2 activity and activation of protein kinase A

1999 • 90 citations

1,25-Dihydroxyvitamin D3 analog structure-function assessment of the rapid stimulation of intestinal calcium absorption (transcaltachia)

1992 • 74 citations

24,25-(OH)2D3 regulates cartilage and bone via autocrine and endocrine mechanisms

2001 • 74 citations

Establishment of the primary structure of the major lipid-dependent Ca2+ binding proteins of chicken growth plate cartilage matrix vesicles: Identity with anchorin cii (annexin V) and annexin II

1992 • 73 citations

Hinge and Amino-Terminal Sequences Contribute to Solution Dimerization of Human Progesterone Receptor

1997 • 73 citations

Differential regulation of prostaglandin E2 synthesis and phospholipase A2 activity by 1,25-(OH)2D3 in three osteoblast-like cell lines (MC-3T3-E1, ROS 17/2.8, and MG-63)

1992 • 70 citations

1,25-Dihydroxyvitamin D3 Stimulates Expression and Translocation of Protein Kinase Cα and Cδ via a Nongenomic Mechanism and Rapidly Induces Phosphorylation of a 33-kDa Protein in Acute Promyelocytic NB4 Cells

1996 • 69 citations

Immunochemical studies on the putative plasmalemmal receptor for 1,25(OH)₂D₃. I. Chick intestine

2000 • 67 citations

Studies on 24R,25-dihydroxyvitamin D3: evidence for a nonnuclear membrane receptor in the chick tibial fracture-healing callus

1998 • 67 citations

1,25-Dihydroxyvitamin D3 translocates protein kinase C beta to nucleus and enhances plasma membrane association of protein kinase C alpha in renal epithelial cells.

1994 • 66 citations

Carboxyl-terminal parathyroid hormone fragments stimulate osteoclast-like cell formation and osteoclastic activity.

1994 • 66 citations

Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites.

1996 • 64 citations

Vitamin D3 analogs stimulate calcium currents in rat osteosarcoma cells.

1994 • 63 citations

1,25(OH)2D3 Regulates Protein Kinase C Activity Through Two Phospholipid-Dependent Pathways Involving Phospholipase A2 and Phospholipase C in Growth Zone Chondrocytes

1998 • 61 citations

Effects of vitamin D metabolites on healing of low phosphate, vitamin D-deficient induced rickets in rats

1985 • 60 citations

Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone.

1992 • 58 citations

Differing shapes of 1α,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor: A status report

1996 • 52 citations

TGFβ1 Regulates 25-Hydroxyvitamin D3 1α- and 24-Hydroxylase Activity in Cultured Growth Plate Chondrocytes in a Maturation-Dependent Manner

1999 • 52 citations

24,25-Dihydroxyvitamin D3 Suppresses the Rapid Actions of 1,25-Dihydroxyvitamin D3 and Parathyroid Hormone on Calcium Transport in Chick Intestine

1999 • 51 citations

Receptor-ligand interactions: A practical approach

1993 • 50 citations

Estradiol binding to synaptosomal plasma membranes of rat brain regions.

1995 • 45 citations

Healing of rachitic lesions in chicks by 24R,25-dihydroxycholecalciferol administered locally into bone

1987 • 43 citations

Calcitonin Receptors on Circulating Normal Human Lymphocytes*

1990 • 41 citations

24R,25-(OH)2 Vitamin D3 Inhibits 1α,25-(OH)2 Vitamin D3 and Testosterone Potentiation of Calcium Channels in Osteosarcoma Cells

1996 • 40 citations

Stimulation of matrix vesicle enzyme activity in osteoblast-like cells by 1,25(OH)2D3 and transforming growth factor β (TGFβ)

1992 • 39 citations

Cartilage and Vitamin D: Genomic and Nongenomic Regulation by 1,25(OH)2D3 and 24,25(OH)2D3

2005 • 39 citations

Physiological Concentrations of 24,25-Dihydroxyvitamin D3 Rapidly Decrease the in Vitro Intestinal Calcium Uptake in the Atlantic Cod, Gadus morhua

1995 • 39 citations

Oscillations in inositol 1,4,5-trisphosphate and diacyglycerol induced by vitamin D3 metabolites in confluent mouse osteoblasts

1993 • 35 citations

Effect of 1,25-dihydroxyvitamin D3 on phospholipid metabolism in a clonal osteoblast-like rat osteogenic sarcoma cell line.

1985 • 34 citations

Hybrid structural analogues of 1,25-(OH)2D3 regulate chondrocyte proliferation and proteoglycan production as well as protein kinase C through a nongenomic pathway

1997 • 25 citations

A specific binding moiety for 1,25-dihydroxyvitamin D₃in basal lateral membranes of carp enterocytes

2000 • 24 citations

The influence of vitamin D metabolites on collagen synthesis by chick cartilage in organ culture

1985 • 24 citations

Evidence for coordinated regulation of osteoblast function by 1,25-dihydroxyvitamin D3 and parathyroid hormone

1996 • 23 citations

Biochemical characterization of positive cooperativity in the binding of 1 alpha, 25-dihydroxyvitamin D3 to its chick intestinal chromatin receptor.

1985 • 22 citations

Clonal Osteoblastic Cell Lines from p53 Null Mouse Calvariae Are Immortalized and Dependent on Bone Morphogenetic Protein 2 for Mature Osteoblastic Phenotype

1997 • 20 citations

Normal levels of the vitamin D receptor and its message in psoriatic skin.

1996 • 20 citations

Adenylate Cyclase of Osteoblast-Like Cells from Rat Osteosarcoma Is Stimulated by Calcitonin as well as Parathyroid Hormone*

1984 • 18 citations

24R,25-Dihydroxyvitamin D3Increases Cyclic GMP Contents, Leading to an Enhancement of Osteocalcin Synthesis by 1,25-Dihydroxyvitamin D3in Cultured Human Osteoblastic Cells

1998 • 16 citations

24,25(OH)2 Vitamin D3 modulates the L-type Ca2+ channel current in UMR 106 cells: involvement of protein kinase A and protein kinase C

1996 • 15 citations

Parathyroid Hormone-Related Protein (107-139) Decreases Alkaline Phosphatase in Osteoblastic Osteosarcoma Cells UMR 106 by a Protein Kinase C-Dependent Pathway

1999 • 13 citations

Treatment of Resting Zone Chondrocytes with Bone Morphogenetic Protein-2 Induces Maturation into a Phenotype Characteristic of Growth Zone Chondrocytes by Downregulating Responsiveness to 24,25(OH)<sub>2</sub>D<sub>3</sub> and Upregulating Responsiveness to 1,25-(OH)<sub>2</sub>D<sub>3</sub>

1998 • 13 citations

Changes in kinetic properties of oxytocin receptors in longitudinal muscle membranes of rat uterus during gestation

1995 • 13 citations

Vitamin D in Teleost Fish. Non-Genomic Regulation of Intestinal Calcium Transport

1999 • 11 citations

"Statistics in Medical Research".

1955 • 8 citations

Biphasic Scatchard plots of oestrogen receptors are associated with low pS2 levels in human breast cancers

1999 • 8 citations