Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Recombinant human bone morphogenetic protein induces bone formation.

1990 • 1,538 citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

1990 • 1,490 citations

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

1994 • 1,442 citations

Molecular Mechanisms Mediating Proliferation/Differentiation Interrelationships During Progressive Development of the Osteoblast Phenotype

1993 • 1,021 citations

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.

1991 • 735 citations

The bone morphogenetic protein family and osteogenesis

1992 • 686 citations

Nucleation of hydroxyapatite by bone sialoprotein.

1993 • 657 citations

Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone.

1994 • 627 citations

Induction of Rapid Osteoblast Differentiation in Rat Bone Marrow Stromal Cell Cultures by Dexamethasone and BMP-2

1994 • 533 citations

The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2

1990 • 498 citations

Bone Morphogenetic Protein-2 Causes Commitment and Differentiation in C3Hl0T1/2 and 3T3 Cells

1993 • 487 citations

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

1984 • 477 citations

Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.

1989 • 440 citations

Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography.

1984 • 433 citations

Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells.

1992 • 395 citations

Dexamethasone induction of osteoblast mRNAs in rat marrow stromal cell cultures

1991 • 347 citations

Expression of Human Bone Morphogenetic Proteins-2 or -4 in Murine Mesenchymal Progenitor C3H10T½ Cells Induces Differentiation into Distinct Mesenchymal Cell Lineages

1993 • 340 citations

Inhibition of hydroxyapatite-crystal growth by bone-specific and other calcium-binding proteins

1986 • 314 citations

What do BMPs do in mammals? Clues from the mouse short-ear mutation

1994 • 300 citations

Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1

1991 • 298 citations

The BMP proteins in bone formation and repair

1992 • 273 citations

Regulation of cartilage and bone differentiation by bone morphogenetic proteins

1992 • 265 citations

Regulatory Role of Transforming Growth Factor-β, Bone Morphogenetic Protein-2, and Protein-4 on Gene Expression of Extracellular Matrix Proteins and Differentiation of Dental Pulp Cells

1994 • 254 citations

Identification of proteins secreted by human osteoblastic cells in culture

1992 • 253 citations

The effects of bone morphogenetic protein-2, -4, and -6 on differentiation of rat osteoblast cells in vitro.

1995 • 241 citations

Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors.

1995 • 228 citations

Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin.

1989 • 224 citations

Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity.

1994 • 223 citations

Developmental Expression of Osteopontin (OPN) mRNA in Rat Tissues: Evidence for a Role for OPN in Bone Formation and Resorption

1993 • 191 citations

High‐resolution immunolocalization of osteopontin and osteocalcin in bone and cartilage during endochondral ossification in the chicken tibia

1992 • 166 citations

Bone morphogenetic proteins (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1 cells in vitro

1991 • 156 citations

Osteopontin and Related Phosphorylated Sialoproteins: Effects on Mineralization^a

1995 • 153 citations

Bone morphogenetic protein-2 but not bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells

1996 • 150 citations

Proteoglycan-type I collagen fibril interactions in bone and non-calcifying connective tissues

1985 • 148 citations

Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: Comparison with TGF-β1

1991 • 129 citations

Expression of bone matrix proteins during dexamethasone-induced mineralization of human bone marrow stromal cells

1996 • 102 citations

Bone sialoprotein mRNA expression and ultrastructural localization in fetal porcine calvarial bone: comparisons with osteopontin

1994 • 102 citations

Bone sialoprotein mRNA expression and ultrastructural localization in fetal porcine calvarial bone: comparisons with osteopontin

1994 • 96 citations

Ultrastructural Immunolocalization of Osteopontin in Metaphyseal and Cortical Bone

1991 • 89 citations

A Mammalian Serine/Threonine Kinase Receptor Specifically Binds BMP-2 and BMP-4

1994 • 86 citations

Osteogenic Protein-1 (BMP-7) Inhibits Cell Proliferation and Stimulates the Expression of Markers Characteristic of Osteoblast Phenotype in Rat Osteosarcoma (17/2.8) Cells

1994 • 82 citations

Stimulation by bone sialoprotein of calcification in osteoblast-like MC3T3-E1 cells

1995 • 76 citations

Transcriptional Regulation of the Human Biglycan Gene

1996 • 74 citations

A bone morphogenetic protein subfamily: Chromosomal localization of human genes for BMP5, BMP6, and BMP7

1992 • 63 citations

Osteogenin (bone morphogenic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow

1995 • 51 citations

Comparative Study of Bone Marrow Induced by Purified BMP and Recombinant Human BMP-2

1995 • 38 citations

Recombinant human bone morphogenetic protein‐2 enhances expression of interleukin‐6 and transforming growth factor‐β1 genes in normal human osteoblast‐like cells

1994 • 38 citations

The effect of glucocorticoid on the synthesis of biglycan and decorin in human osteoblasts and bone marrow stromal cells.

1994 • 34 citations

Bone morphogenetic proteins (BMP‐2 and BMP‐3) induce the late phase expression of the proto‐oncogene c‐fos in murine osteoblastic MC3T3‐E1 cells

1992 • 32 citations

Effect of protein and steroidal osteotropic agents on differentiation and epidermal growth factor‐mediated growth of the CFK1 osseous cell line

1992 • 29 citations

Evidence That Human Bone Cells in Culture Contain Binding Sites for Osteogenic Protein-1

1994 • 12 citations