Transferrin: Evolution and Genetic Regulation of Expression

Protides of the Biological Fluids

1969 • 1,623 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN

1958 • 1,401 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

Iron Transport and Storage Proteins

1980 • 1,183 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Methods for growth of cultured cells in serum-free medium

1980 • 1,013 citations

Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.

1979 • 975 citations

Iron withholding: a defense against infection and neoplasia.

1984 • 893 citations

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

1982 • 877 citations

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin.

1981 • 685 citations

The Origin of Man: A Chromosomal Pictorial Legacy

1982 • 665 citations

The regional distribution and cellular localization of iron in the rat brain

1984 • 487 citations

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

1981 • 473 citations

Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2.

1983 • 448 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Functional and Morphologic Characterization of Human T Cells Continuously Grown in Vitro

1977 • 410 citations

The plasma proteins : structure, function, and genetic control

1975 • 388 citations

A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells

1984 • 365 citations

Studies on glycoconjugates. LXIV. Complete structure of two carbohydrate units of human serotransferrin

1975 • 361 citations

Sertoli cells synthesize and secrete transferrin-like protein.

1980 • 360 citations

Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences

1985 • 353 citations

An Iron-binding Component in Human Blood Plasma

1946 • 349 citations

Ultrastructure and function of the Sertoli cell

1975 • 320 citations

Human transferrin: cDNA characterization and chromosomal localization.

1984 • 320 citations

Synthesis of Serum Albumin, Prealbumin, α-Foetoprotein, α1-Antitrypsin and Transferrin by the Human Yolk Sac

1970 • 280 citations

The primary structure of human serum transferrin. The structures of seven cyanogen bromide fragments and the assembly of the complete structure.

1983 • 272 citations

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1982 • 265 citations

Secretion of Testicular Transferrin by Cultured Sertoli Cells is Regulated by Hormones and Retinoids

1982 • 253 citations

Lactotransferrin is the major estrogen inducible protein of mouse uterine secretions.

1987 • 242 citations

Raw Hen Egg White and the Role of Iron In Growth Inhibition of Shigella dysenteriae , Staphylococcus aureus , Escherichia coli and Saccharomyces cerevisiae

1944 • 237 citations

Lymphokines and aging: interleukin-2 production and activity in aged animals.

1981 • 234 citations

Rat transferrin gene expression: tissue-specific regulation by iron deficiency.

1986 • 222 citations

Transferrin gene expression visualized in oligodendrocytes of the rat brain by using in situ hybridization and immunohistochemistry.

1985 • 214 citations

Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution.

1985 • 209 citations

Organisation and sequence studies of the 17-piece chicken conalbumin gene

1979 • 199 citations

The Primary Structure of Hen Ovotransferrin

1982 • 199 citations

Building a metal-responsive promoter with synthetic regulatory elements.

1985 • 199 citations

Nucleotide sequence of cloned rat serum albumin messenger RNA.

1981 • 198 citations

High prealbumin and transferrin mRNA levels in the choroid plexus of rat brain

1985 • 190 citations

Detection of factors that interact with the human β-interferon regulatory region in vivo by DNAase I footprinting

1986 • 188 citations

Sexual Dimorphism in the Liver

1983 • 188 citations

The Complete Nucleotide Sequence of the Chicken Ovotransferrin mRNA

1982 • 181 citations

The genealogy of some recently evolved vertebrate proteins

1985 • 179 citations

Proteins of iron storage and transport

1986 • 173 citations

Plasma protein secretion by the liver

1983 • 165 citations

Molecular Biology of Aging: Gene Stability and Gene Expression

1986 • 163 citations

Transferrin as a fetal growth factor: acquisition of responsiveness related to embryonic induction.

1983 • 158 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids: Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Fibroblast Hybrids

1972 • 158 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids: Reappearance of Tyrosine Aminotransferase Inducibility after the Loss of Chromosomes

1971 • 154 citations

The action of estrogen and progesterone on the expression of the transferrin gene. A comparison of the response in chick liver and oviduct.

1978 • 154 citations

Role of T cells and adherent cells in age-related decline in murine interleukin 2 production.

1982 • 153 citations

Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization.

1966 • 148 citations

Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids.

1985 • 146 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids, I. Tyrosine Aminotransferase in Hepatoma-Fibroblast Hybrids

1971 • 146 citations

Distribution of transferrin synthesis in brain and other tissues in the rat.

1987 • 144 citations

Characterization, mapping, and expression of the human ceruloplasmin gene.

1986 • 139 citations

Organization of the human transferrin gene: direct evidence that it originated by gene duplication.

1985 • 136 citations

Expression of the transferrin gene during development of non-hepatic tissues: High level of transferrin mRNA in fetal muscle and adult brain

1984 • 129 citations

Expression of the chicken transferrin gene in transgenic mice

1983 • 126 citations

Transferrin Messenger Ribonucleic Acid: Molecular Cloning and Hormonal Regulation in Rat Sertoli Cells*

1987 • 123 citations

Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, α-antitrypsin, C8, and factor B

1980 • 122 citations

The evolution of transferrin

1982 • 114 citations

Studies on the Capacity of Serum to Bind Iron. A contribution to our knowledge of the regulation mechanism of serum iron

1945 • 109 citations

Transferrin gene expression. Regulation of mRNA transcription in chick liver by steroid hormones and iron deficiency.

1980 • 109 citations

Transferrin synthesis by inducer T lymphocytes.

1986 • 107 citations

Receptor for transferrin may be a "target" structure for natural killer cells.

1983 • 103 citations

A myotrophic protein from chick embryo extract: Its purification, identity to transferrin, and indispensability for avian myogenesis

1982 • 103 citations

Human alpha 2-HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript.

1987 • 101 citations

Tissue-specific expression of the rat albumin gene: genetic control of its extinction in microcell hybrids.

1986 • 100 citations

Acquisition of iron from transferrin regulates reticulocyte heme synthesis.

1985 • 97 citations

Differential Regulation of Testicular Transferrin and Androgen-Binding Protein Secretion in Primary Cultures of Rat Sertoli Cells*

1986 • 96 citations

Age-dependent regulation of the polymorphic forms of alpha 2u-globulin.

1983 • 93 citations

Transferrin gene expression. Effects of nutritional iron deficiency.

1980 • 91 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids: High Frequency of Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Lymphoblast Hybrids

1974 • 88 citations

The effect of aging on the expression of interleukin 2 messenger ribonucleic acid

1986 • 85 citations

Perspectives on copper biochemistry.

1986 • 84 citations

Synthesis, Processing, and Secretion of Plasma Proteins by the Liver and Other Organs and Their Regulation

1987 • 83 citations

Trophoblast transferrin and transferrin receptors in the host–parasite relationship of human pregnancy

1979 • 81 citations

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3

1983 • 79 citations

The effect of iron and transferrin on the response of serum-free cultures of mouse lymphocytes to concanavalin A and lipopolysaccharide.

1981 • 77 citations

Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions.

1986 • 76 citations

Regions of complementarity between the messenger RNAs for epidermal growth factor, transferrin, interleukin-2 and their respective receptors

1985 • 74 citations

Interleukin-2 production and activity in aged humans

1985 • 73 citations

Phenotypic exclusion in mouse melanoma-rat hepatoma hybrid cells: Pigment and albumin production are not reexpressed simultaneously

1978 • 71 citations

The role of iron and transferrin in lymphocyte transformation

1983 • 71 citations

Structure and function of the transferrin receptor.

1983 • 68 citations

A genetic analysis of extinction: trans-regulation of 16 liver-specific genes in hepatoma-fibroblast hybrid cells.

1987 • 67 citations

Direct measurement of the rates of synthesis of plasma proteins in control subjects and patients with gastrointestinal protein loss

1968 • 65 citations

A mono-sited transferrin from a representative deuterostome: the ascidian Pyura stolonifera (subphylum Urochordata)

1984 • 65 citations

Sites of Formation of the Serum Proteins Transferrin and Hemopexin

1973 • 64 citations

CHROMOSOMAL PHYLOGENY OF THE PRIMATES

1978 • 61 citations

The location and synthesis of transferrin in mouse embryos and teratocarcinoma cells

1982 • 58 citations

Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9

1987 • 57 citations

Mapping of aminoacylase-1 and beta-galactosidase-A to homologous regions of human chromosome 3 and mouse chromosome 9 suggests location of additional genes.

1982 • 55 citations

Plasma Protein Turnover

1976 • 55 citations

Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase

1972 • 54 citations

The human transferrin gene: 5′ region contains conserved sequences which match the control elements regulated by heavy metals, glucocorticoids and acute phase reaction

1986 • 54 citations

Hormone and Age-Dependent Regulation of α2u-Globulin Gene Expression

1983 • 51 citations

Chromosomal assignment and trans regulation of the tyrosine aminotransferase structural gene in hepatoma hybrid cells.

1985 • 51 citations

Developmental changes in microheterogeneity of foetal plasma glycoproteins of mice

1973 • 49 citations

Transferrin is required for early tooth morphogenesis

1984 • 49 citations

Effect of iron deficiency on the response of mouse lymphocytes to concanavalin A: the importance of transferrin-bound iron.

1985 • 48 citations

Mechanism of the age-related decline in lymphocyte proliferation: Role of IL-2 production and protein synthesis

1983 • 47 citations

Albumin and transferrin synthesis during development in the rat

1974 • 46 citations

A Chicken Transferrin Gene in Transgenic Mice Escapes X-Chromosome Inactivation

1987 • 46 citations

Transferrin in Disease II: Defects in the Regulation of Transferrin Saturation with Iron Contribute to Susceptibility to Infection

1984 • 45 citations

The effect of cortisol on the synthesis of rat plasma albumin, fibrinogen and transferrin

1972 • 43 citations

Plasma Protein Turnover

1976 • 43 citations

Regional localization of the human transferrin receptor gene to 3q26.2----qter.

1985 • 42 citations

Comparison of factor IX methylation on human active and inactive X chromosomes: implications for X inactivation and transcription of tissue-specific genes.

1986 • 42 citations

Transferrin in foetal and adult mouse tissues: synthesis, storage and secretion

1985 • 39 citations

Differentiation of Dictyostelium discoideum in monolayer cultures and its modification by ionic conditions

1984 • 37 citations

The Comparative Effects of Nutritional and Hormonal Factors on the Synthesis of Albumin, Fibrinogen and Transferrin

1973 • 36 citations

Evidence that transferrin may function exclusively as an iron donor in promoting lymphocyte proliferation.

1986 • 35 citations

Synthesis of transferrin by human peripheral blood lymphocytes.

1970 • 35 citations

Chromosome 3q (22-ter) encodes the human transferrin receptor.

1983 • 34 citations

THE EVOLUTION OF THE VERTEBRATE PLASMA PROTEINS

1987 • 33 citations

The present state of the human lactotransferrin sequence

1981 • 32 citations

Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization

1988 • 30 citations

Amniotic fluid proteins: Evidence for the presence of fetal plasma glycoproteins in mouse amniotic fluid

1972 • 28 citations

Alpha, Beta, Gamma, Omega—The Structure of the Plasma Proteins

1984 • 27 citations

The importance of iron in the pathogenesis of infection and neoplasia

1985 • 26 citations

Selective inhibition of the growth of human erythroid bursts by monoclonal antibodies against transferrin or the transferrin receptor

1986 • 23 citations

Plasma protein metabolism during lactation in the rabbit

1970 • 22 citations

Estrogen regulation of the avian transferrin gene in transgenic mice.

1986 • 22 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids v. Re-Expression of Aldolase B In vitro and in vivo

1974 • 21 citations

The role of transferrin in natural killer cell and IL-2-induced cytotoxic cell function

1986 • 20 citations

Plasma protein synthesis by tissue slices from pregnant and lactating rats

1969 • 20 citations

Studies on the mechanism of specificity of human natural killer cells for tumor cells: Correlation between target cell transferrin receptor expression and competitive activity

1985 • 20 citations

Contrasting levels of transferrin gene activity in cultured rat Sertoli cells and intact seminiferous tubules.

1986 • 20 citations

Human α<sub>2</sub>-HS-glycoprotein localized to 3q27→q29 by in situ hybridization

1988 • 19 citations

Plasma-protein production by rat hepatoma cells in culture, their variants and revertants

1986 • 19 citations

Regulatory Factors in the Synthesis of Plasma Proteins by the Isolated Perfused rat Liver

1973 • 18 citations

The 5′ region of the human transferrin gene: structure and potential regulatory sites

1986 • 17 citations

Evolution of the Vertebrate Plasma Proteins

1984 • 17 citations

THE EFFECT OF AGE, SEX, PREGNANCY, OESTROGEN AND PROGESTOGEN ON RAT SERUM PROTEINS

1972 • 17 citations

Evidence for linkage between the loci for transferrin and ceruloplasmin in man

1983 • 17 citations

Induction of foreign genes in animals

1982 • 16 citations

Stimulation of haem synthesis by erythropoietin in mouse yolk-sac-stage embryonic cells

1971 • 13 citations

DNA Sequencing and Chromosomal Locations of Human Plasma Protein Genes

1987 • 13 citations

Transient transcriptional inhibition of the transferrin gene by cyclic AMP

1985 • 13 citations

Extinction, Retention and Induction of Serum Protein Secretion in Hepatoma-fibroblast Hybrids

1976 • 11 citations

Plasma protein turnover and transmission to the milk in the rat

1968 • 10 citations

Studies on regulatory factors in transferrin metabolism in man and the experimental rat

1976 • 9 citations

Molecular Genetics of Human Transferrin

1985 • 3 citations

Direct measurement of transferrin synthesis rates in man using the [14C]carbonate method

1980 • 2 citations

EXPRESSION OF GENES ENCODING THE VITAMIN D BINDING PROTEIN AND TRANSFERRIN

1987 • 2 citations

Deleted Work

1955 • 0 citations