The simian virus 40 large tumor antigen

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Sequence requirements for nuclear location of simian virus 40 large-T antigen

1984 • 1,278 citations

Complete nucleotide sequence of SV40 DNA

1978 • 1,050 citations

Die Molekularbiologie der Tumorviren

1977 • 951 citations

The Genome of Simian Virus 40

1978 • 948 citations

Simian Virus 40 Deoxyribonucleic Acid Synthesis: the Viral Replicon

1972 • 609 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

The Escherichia coli dnaB replication protein is a DNA helicase.

1986 • 510 citations

Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors

1984 • 492 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

DNA helicase activity of SV40 large tumor antigen.

1986 • 438 citations

Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens

1980 • 430 citations

Bidirectional SV40 Transcription Mediated by Tandem Sp1 Binding Interactions

1985 • 413 citations

Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells.

1985 • 380 citations

Absence of nucleosomes in a fraction of SV40 chromatin between the origin of replication and the region coding for the late leader RNA

1980 • 372 citations

Structure of replicating simian virus 40 minichromosomes

1986 • 340 citations

Activation of the SV40 late promoter: Direct effects of T antigen in the absence of viral DNA replication

1984 • 292 citations

Initiation of SV40 DNA replication in vivo: Location and structure of 5′ ends of DNA synthesized in the ori region

1982 • 257 citations

A nucleosome-free region in SV40 minichromosomes

1980 • 254 citations

Proteins Controlling the Helical Structure of DNA

1981 • 253 citations

Activation of mouse genes in transformed cells

1983 • 252 citations

Extensive unwinding of the plasmid template during staged enzymatic initiation of DNA replication from the origin of the Escherichia coli chromosome

1986 • 249 citations

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

1984 • 248 citations

Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies.

1984 • 216 citations

Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene.

1983 • 210 citations

T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication.

1986 • 200 citations

Simian Virus 40 Large T Antigen Is Phosphorylated at Multiple Sites Clustered in Two Separate Regions

1982 • 193 citations

Transcription Control by Oncogenes

1985 • 176 citations

Transient gene expression control: effects of transfected DNA stability and trans-activation by viral early proteins.

1985 • 174 citations

Functional interactions of the simian virus 40 core origin of replication with flanking regulatory sequences

1986 • 166 citations

Biochemical activities of T-antigen proteins encoded by simian virus 40 A gene deletion mutants.

1983 • 164 citations

Domain Structure of the Simian Virus 40 Core Origin of Replication

1986 • 160 citations

Regulatory mutants of simian virus 40

1982 • 157 citations

Functional organization of the simian virus 40 origin of DNA replication.

1986 • 157 citations

A poly(dT)-stimulated ATPase activity associated with simian virus 40 large T antigen.

1979 • 155 citations

Simian virus 40 early- and late-region promoter functions are enhanced by the 72-base-pair repeat inserted at distant locations and inverted orientations.

1983 • 149 citations

Expression of enhanced levels of small RNA polymerase III transcripts encoded by the B2 repeats in simian virus 40-transformed mouse cells

1985 • 139 citations

Detection and characterization of multiple forms of simian virus 40 large T antigen

1981 • 134 citations

Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference

1984 • 131 citations

Regulation of SV40 DNA replication by phosphorylation of T antigen.

1987 • 130 citations

Different structural systems of the nucleus are targets for SV40 large T antigen

1983 • 125 citations

Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts.

1985 • 119 citations

Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen

1982 • 117 citations

Modification of SV40 T antigen by poly ADP-ribosylation

1981 • 110 citations

Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants

1985 • 110 citations

Simian virus 40 origin DNA-binding domain on large T antigen

1986 • 109 citations

Organization and Replication of Viral DNA

1982 • 109 citations

SV40 T antigen binds specifically to a cellular 53 K protein in vitro

1981 • 107 citations

Topography of simian virus 40 A protein-DNA complexes: arrangement of protein bound to the origin of replication

1983 • 104 citations

SV40 large tumor antigen can regulate some cellular transcripts in a positive fashion

1982 • 102 citations

Initiation of simian virus 40 DNA replication in vitro

1983 • 93 citations

Simian Virus 40 Mutants with Deletions at the 3′ End of the Early Region Are Defective in Adenovirus Helper Function

1979 • 90 citations

The T-antigen-binding domain of the simian virus 40 core origin of replication

1987 • 87 citations

Acylated simian virus 40 large T-antigen: a new subclass associated with a detergent-resistant lamina of the plasma membrane.

1983 • 85 citations

The plasma-membrane-associated form of SV40 large tumor antigen: biochemical and biological properties

1986 • 83 citations

Domain structure of the simian virus 40 core origin of replication.

1986 • 78 citations

Monoclonal antibodies as probes for a function of large T antigen during the elongation process of simian virus 40 DNA replication

1987 • 78 citations

A large-tumor-antigen-specific monoclonal antibody inhibits DNA replication of simian virus 40 minichromosomes in an in vitro elongation system

1985 • 74 citations

Properties of the simian virus 40 (SV40) large T antigens encoded by SV40 mutants with deletions in gene A

1986 • 72 citations

Differential ability of a T-antigen transport-defective mutant of simian virus 40 to transform primary and established rodent cells.

1985 • 69 citations

Simian Virus 40 Large T-Antigen Point Mutants That Are Defective in Viral DNA Replication but Competent in Oncogenic Transformation

1984 • 68 citations

Seventeen base pairs of region I encode a novel tripartite binding signal for SV40 T antigen

1985 • 67 citations

Polyoma virus-transformed cells produce transforming growth factor(s) and grow in serum-free medium

1982 • 64 citations

Simian Virus 40 DNA Replication: Functional Organization of Regulatory Elements

1986 • 60 citations

DNA-binding region of the simian virus 40 tumor antigen

1986 • 59 citations

Specific association of simian virus 40 tumor antigen with simian virus 40 chromatin

1980 • 57 citations

The nucleotide binding site detected by affinity labeling in the large T proteins of polyoma and SV40 viruses is distinct from their ATPase catalytic site.

1984 • 53 citations

Analysis of a transgenic mouse containing simian virus 40 and v-myc sequences.

1985 • 50 citations

Single strand DNA binding of simian virus 40 tumor antigen.

1979 • 50 citations

Mammalian DNA helicase

1985 • 44 citations

Simian virus 40 large tumor antigen on replicating viral chromatin: tight binding and localization on the viral genome

1983 • 43 citations

DNA polymerase alpha from the nuclear matrix of cells infected with simian virus 40

1982 • 42 citations

Sequence-specific binding of simian virus 40 A protein to nonorigin and cellular DNA.

1984 • 42 citations

trans Activation of the simian virus 40 enhancer.

1986 • 40 citations

DNA-dependent adenosine triphosphatase B from mouse FM3A cells has DNA helicase activity

1987 • 38 citations

Association of simian virus 40 T antigen with replicating nucleoprotein complexes of simian virus 40

1980 • 38 citations

Simian virus 40 large T-antigen point mutants that are defective in viral DNA replication but competent in oncogenic transformation.

1984 • 37 citations

Construction and Characterization of Viable Deletion Mutants of Simian Virus 40 Lacking Sequences near the 3′ End of the Early Region

1982 • 36 citations

E. coli recA protein possesses a strand separating activity on short duplex DNAs.

1985 • 35 citations

Binding of simian virus 40 a protein to DNA with deletions at the origin of replication

1984 • 32 citations

A second domain of simian virus 40 T antigen in which mutations can alter the cellular localization of the antigen.

1986 • 32 citations

Phosphorylation and dephosphorylation alter the structure of D2 hybrid T antigen

1982 • 26 citations

Use of simian virus 40 large T-beta-galactosidase fusion proteins in an immunochemical analysis of simian virus 40 large T antigen

1985 • 25 citations

Two major replicating simian virus 40 chromosome classes. Synchronous replication fork movement is associated with bound large T antigen during elongation.

1987 • 25 citations

Chromatin replication revealed by studies of animal cells and papovaviruses (simian virus 40 and polyoma virus).

1979 • 25 citations

Glycosylation of simian virus 40 T antigen and localization of glycosylated T antigen in in the nuclear matrix

1987 • 24 citations

Subclasses of simian-virus-40 large tumor antigen. Partial purification and DNA-binding properties of two subclasses of tumor antigen from productively infected cells.

1982 • 23 citations

Dynamic nature of the association of large tumor antigen and p53 cellular protein with the surfaces of simian virus 40-transformed cells

1984 • 22 citations

Simian virus 40 DNA replication: functional organization of regulatory elements.

1986 • 22 citations

New Properties of Simian Virus 40 Large T Antigen

1982 • 21 citations

DNA-binding properties of phosphorylated and dephosphorylated D2-T antigen, a simian-virus-40 T-antigen-related protein

2008 • 20 citations

DNA-binding proteins and DNA-unwinding enzymes in eukaryotes

1980 • 19 citations

Subclasses of Simian-Virus-40 Large Tumor Antigen

2005 • 13 citations

The Simian‐Virus‐40 Large‐Tumor Antigen in Replicating Viral Chromatin

1983 • 13 citations

Stimulation of DNA polymerase α by a nuclear DNA/protein complex

1981 • 8 citations

Mutagenic activity of transforming genes

1986 • 5 citations