Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials

International Staging System for Multiple Myeloma

2005 • 2,696 citations

A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma

2003 • 2,642 citations

Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma

2005 • 2,457 citations

A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma

2004 • 758 citations

Thalidomide and Hematopoietic-Cell Transplantation for Multiple Myeloma

2006 • 749 citations

The Ubiquitin-Proteasome Pathway and Its Role in Cancer

2005 • 529 citations

Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities

1995 • 418 citations

Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study

2006 • 394 citations

Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy

2005 • 356 citations

Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities

2000 • 333 citations

Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization

2000 • 328 citations

Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy

2001 • 314 citations

Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants.

1997 • 187 citations

Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (delta13) in multiple myeloma: an eastern cooperative oncology group study.

2002 • 185 citations

The occurrence of graft-versus-host disease is the major predictive factor for response to donor lymphocyte infusions in multiple myeloma

2004 • 183 citations

Prognostic Value of Numerical Chromosome Aberrations in Multiple Myeloma: A FISH Analysis of 15 Different Chromosomes

1998 • 180 citations

Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myeloma

2002 • 163 citations

Prognostic impact of cytogenetic and interphase fluorescence in situ hybridization‐defined chromosome 13 deletion in multiple myeloma: early results of total therapy II

2002 • 159 citations

Extended follow‐up of a phase II trial in relapsed, refractory multiple myeloma:

2006 • 148 citations

Prognostic value of cytogenetics in multiple myeloma

1998 • 145 citations

Prognostic and Therapeutic Significance of Myeloma Genetics and Gene Expression Profiling

2005 • 131 citations

Cytogenetic Abnormalities Correlate with the Plasma Cell Labeling Index and Extent of Bone Marrow Involvement in Myeloma

1999 • 105 citations

Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation

2004 • 101 citations

Bortezomib in combination with dexamethasone for relapsed multiple myeloma

2005 • 61 citations

Proteasome inhibitors induce growth inhibition and apoptosis in myeloma cell lines and in human bone marrow myeloma cells irrespective of chromosome 13 deletion

2003 • 50 citations

Multiple myeloma with deletion of chromosome 13q is characterized by increased bone marrow neovascularization

2000 • 40 citations

Both chromosome 13 abnormalities by metaphase cytogenetics and deletion of 13q by interphase FISH only are prognostically relevant in multiple myeloma

2003 • 35 citations

Determination of chromosome 13 status in bone marrow cells of patients with multiple myeloma using combined morphologic and fluorescence in situ hybridization analysis

2004 • 14 citations

Chromosome 13 Deletion/Hypodiploidy and Prognosis in Multiple Myeloma Patients

2004 • 11 citations