Emerging roles of purinergic signaling in gastrointestinal epithelial secretion and hepatobiliary function

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

5′-Nucleotidase: molecular structure and functional aspects

1992 • 864 citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 • 647 citations

Cellular and molecular physiology of volume-sensitive anion channels

1996 • 620 citations

Adenosine Receptor Subtypes: Characterization and Therapeutic Regulation

1995 • 540 citations

Ecto-ATPases: Identities and Functions

1995 • 503 citations

Nucleoside and nucleobase transport systems of mammalian cells

1996 • 496 citations

Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis

1991 • 495 citations

The erythrocyte as a regulator of vascular tone

1995 • 488 citations

Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin

1997 • 477 citations

Cloning of a human nucleoside transporter implicated in the Cellular uptake of adenosine and chemotherapeutic drugs

1997 • 426 citations

Immunocytochemical localization of the cystic fibrosis gene product CFTR.

1991 • 419 citations

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

1997 • 411 citations

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

1994 • 410 citations

Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells

1992 • 373 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.

1994 • 354 citations

Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells

1993 • 347 citations

Towards a revised nomenclature for P1 and P2 receptors

1997 • 347 citations

Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.

1994 • 344 citations

Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

1996 • 328 citations

P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure

1995 • 323 citations

Purification and Cloning of a Soluble ATP-Diphosphohydrolase (Apyrase) from Potato Tubers (Solanum tuberosum)

1996 • 319 citations

Activation of ion transport pathways by changes in cell volume

1991 • 306 citations

Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.

1991 • 296 citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1993 • 296 citations

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.

1993 • 294 citations

Deformation-induced ATP release from red blood cells requires CFTR activity

1998 • 288 citations

Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation

1997 • 286 citations

Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta

1997 • 278 citations

Regulation of cell function by the cellular hydration state

1994 • 270 citations

Characterization of responses of isolated rat hepatocytes to ATP and ADP.

1985 • 269 citations

CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli

1997 • 263 citations

Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype.

1992 • 259 citations

Cloning, Functional Expression and Tissue Distribution of the Human P2Y6Receptor

1996 • 255 citations

Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation

1997 • 249 citations

Bioluminescence detection of ATP release mechanisms in epithelia

1998 • 242 citations

Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)

1997 • 237 citations

A release mechanism for stored ATP in ocular ciliary epithelial cells

1998 • 233 citations

Molecular Cloning and Functional Characterization of Nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) Equilibrative Nucleoside Transporter Proteins (rENT1 and rENT2) from Rat Tissues

1997 • 227 citations

An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain

1997 • 226 citations

Cloning of the Human Equilibrative, Nitrobenzylmercaptopurine Riboside (NBMPR)-insensitive Nucleoside Transporter ei by Functional Expression in a Transport-deficient Cell Line

1998 • 225 citations

Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides.

1996 • 225 citations

The A Adenosine Receptor Mediates cAMP Responses to Adenosine Receptor Agonists in Human Intestinal Epithelia

1995 • 223 citations

Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein.

1994 • 218 citations

Rapid release of endothelin and ATP from isolated aortic endothelial cells exposed to increased flow

1990 • 211 citations

Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases

1998 • 188 citations

Increased release of ATP from endothelial cells during acute inflammation

1998 • 185 citations

Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP

1996 • 184 citations

Hepatocellular ATP-binding Cassette Protein Expression Enhances ATP Release and Autocrine Regulation of Cell Volume

1997 • 165 citations

Cystic Fibrosis Transmembrane Regulator-independent Release of ATP

1998 • 162 citations

Primary Structure and Functional Expression of a cDNA Encoding the Bile Canalicular, Purine-specific Na+-Nucleoside Cotransporter

1995 • 162 citations

Purinergic axis in cardiac blood vessels. Agonist-mediated release of ATP from cardiac endothelial cells.

1994 • 160 citations

Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype

1992 • 156 citations

P2 Purinoceptors: Historical Perspective and Classification

2007 • 147 citations

Primary structure of human placental 5′‐nucleotidase and identification of the glycolipid anchor in the mature form

1990 • 145 citations

ATP-Stimulated Release of ATP by Human Endothelial Cells

1996 • 136 citations

MDR Expression in Normal Tissues: Pharmocologic Implication for the Clinical Use of P-Glycoprotein Inhibitors

1995 • 134 citations

Primary structure of rat liver 5'-nucleotidase deduced from the cDNA. Presence of the COOH-terminal hydrophobic domain for possible post-translational modification by glycophospholipid.

1990 • 134 citations

Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation

1997 • 131 citations

Na⁺-dependent purine nucleoside transporter from human kidney: cloning and functional characterization

1997 • 129 citations

ATP released by LPS increases nitric oxideproduction in raw 264.7 macrophage cell line viaP2ZP2X7 receptors

1998 • 125 citations

CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates

1998 • 125 citations

Adenine Nucleotides in the Secretory Granule Fraction of Rat Islets¹

1975 • 121 citations

Simultaneous recording of action potentials from endocardium and epicardium during ischemia in the isolated cat ventricle: relation of temporal electrophysiologic heterogeneities to arrhythmias.

1986 • 121 citations

Complementary DNA Cloning and Sequencing of the Chicken Muscle Ecto-ATPase

1997 • 119 citations

Purified Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Does Not Function as an ATP Channel

1996 • 115 citations

The CD39-like Gene Family: Identification of Three New Human Members (CD39L2, CD39L3, and CD39L4), Their Murine Homologues, and a Member of the Gene Family fromDrosophila melanogaster

1998 • 115 citations

Identification of an Ecto-nucleoside Diphosphokinase and Its Contribution to Interconversion of P2 Receptor Agonists

1997 • 114 citations

Phosphatidylinositol 3-Kinase Contributes to Cell Volume Regulation through Effects on ATP Release

1998 • 114 citations

Shear Stress-induced [Ca2+]i Transients and Oscillations in Mouse Fibroblasts Are Mediated by Endogenously Released ATP

1995 • 111 citations

Synergistic effect of acute hypoxia on flow-induced release of ATP from cultured endothelial cells

1995 • 108 citations

Actions of extracellular UTP and ATP in perfused rat liver

1987 • 107 citations

Characterization and Expression of the Human A2a Adenosine Receptor Gene

1996 • 106 citations

Receptors responsive to extracellular pyrimidine nucleotides

1997 • 99 citations

Propagation of Mechanically Induced Intercellular Calcium Waves via Gap Junctions and ATP Receptors in Rat Liver Epithelial Cells

1997 • 99 citations

Purinergic regulation of anion secretion by cystic fibrosis pancreatic duct cells

1996 • 97 citations

Functional and molecular characteristics of Na(+)-dependent nucleoside transporters.

1997 • 95 citations

CFTR Channels Expressed in CHO Cells Do Not Have Detectable ATP Conductance

1996 • 95 citations

Adenosine nucleotides in bile

1996 • 94 citations

Studies on the release and extracellular metabolism of endogenous ATP in rat superior cervical ganglion: support for neurotransmitter role of ATP

1997 • 91 citations

Cystic Fibrosis Transmembrane Conductance Regulator-associated ATP and Adenosine 3′-Phosphate 5′-Phosphosulfate Channels in Endoplasmic Reticulum and Plasma Membranes

1997 • 90 citations

Cellular ATP release by the cystic fibrosis transmembrane conductance regulator

1996 • 89 citations

Adenosine triphosphate activates ion permeabilities in biliary epithelial cells

1994 • 85 citations

Vascular control by purines with emphasis on the coronary system

1989 • 84 citations

Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2.

1994 • 84 citations

Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene

1997 • 83 citations

Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: Evidence for A2 receptors on rat kupffer cells

1994 • 82 citations

P2 purinoceptors : localization, function, and transduction mechanisms

1996 • 82 citations

Characterization of the cystic fibrosis transmembrane conductance regulator in a colonocyte cell line.

1992 • 79 citations

Expression of Purinergic Receptor Channels and Their Role in Calcium Signaling and Hormone Release in Pituitary Gonadotrophs

1996 • 79 citations

Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes

1997 • 77 citations

Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes.

1996 • 76 citations

A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane.

1992 • 71 citations

Evidence for a role of pituitary ATP receptors in the regulation of pituitary function.

1995 • 70 citations

Prostaglandin F2α and D2 release from primary ito cell cultures after stimulation with noradrenaline and ATP but not adenosine

1994 • 69 citations

Na+-dependent nucleoside transport in liver: two different isoforms from the same gene family are expressed in liver cells

1998 • 69 citations

The human P2×1 receptor: molecular cloning, tissue distribution, and localization to chromosome 171

1996 • 67 citations

Sodium-dependent nucleoside transport in the human intestinal brush-border membrane

1997 • 67 citations

Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1rat) by transient expression in cultured mammalian cells

1996 • 65 citations

The cystic fibrosis transmembrane conductance regulator and ATP

1997 • 62 citations

ATP increases [Ca2+]i and ion secretion via a basolateral P2Y-receptor in rat distal colonic mucosa

1997 • 61 citations

Production and characterization of multiple antigenic peptide antibodies to the adenosine A2b receptor.

1995 • 60 citations

Role of purinergic receptors in chloride secretion in Caco-2 cells

1997 • 57 citations

Functional Properties of Native and Cloned P2X Receptors

2007 • 56 citations

Activation of CFTR Cl- conductance in polarized T84 cells by luminal extracellular ATP

1995 • 54 citations

Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium

1994 • 54 citations

Purinergic receptor activation of Cl- secretion in T84 cells

1992 • 53 citations

The molecular basis for the storage and release of histamine in rat mast cell granules

1974 • 52 citations

Ectonucleotidases, purine nucleoside transporter, and function of the bile canalicular plasma membrane of the hepatocyte

1997 • 52 citations

Secretory effects of ATP on nontransformed dog pancreatic duct epithelial cells

1998 • 51 citations

Release of ATP from Heart

1990 • 45 citations

ATP release and contraction mediated by different P2‐receptor subtypes in guinea‐pig ileal smooth muscle

1997 • 44 citations

Cellular Distribution of the P2X4 ATP Receptor mRNA in the Brain and Non-Neuronal Organs of Rats.

1996 • 44 citations

Nucleotide receptors activate cation, potassium, and chloride currents in a liver cell line

1994 • 41 citations

Expression of Drosophila melanogaster P-glycoproteins is associated with ATP channel activity

1996 • 35 citations

Hepatocellular Transport: Role of ATP-Binding Cassette Proteins

1996 • 33 citations

Cell volume and hepatocellular function

1995 • 31 citations

Molecular Cloning of the Chicken Oviduct Ecto-ATP-Diphosphohydrolase

1998 • 31 citations

Characterization of the biological effects of 2‐methylthio‐ATP on rat hepatocytes: clear‐cut differences with ATP

1991 • 29 citations

Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine

1990 • 29 citations

Messung der Serum-Insulin-Aktivität mit epididymalem Ratten-Fettgewebein vitro

1959 • 25 citations

Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membrane

1996 • 25 citations

Prostanoid secretion by rat hepatic sinusoidal endothelial cells and its regulation by exogenous adenosine triphosphate

1995 • 24 citations

Extracellular ATP as an autocrine/paracrine regulator of prolactin release

1997 • 23 citations

Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells

1996 • 21 citations

Electrophysiological effects of extracellular ATP on Necturus gallbladder epithelium.

1991 • 20 citations

ATP Compartmentation in Neuroendocrine Secretory Vesicles

1990 • 19 citations

Adenosine transport in rat liver plasma membrane vesicles

1991 • 19 citations

Hepatic heterogeneity in the response to ATP studied in the bivascularly perfused rat liver.

1998 • 18 citations

Purinergic agonist and G protein stimulation of phospholipase D in rat liver plasma membranes. Independence from phospholipase C activation

1995 • 17 citations

Modulation of maximal glycogenolysis in perfused rat liver by adenosine and ATP

1991 • 16 citations

ATP release by angiotensin II from segments and cultured smooth muscle cells of guinea-pig taenia coil

1996 • 13 citations

Mn2+ does not uncouple adenosine “Ra” receptors from the liver adenylate cyclase

1982 • 11 citations

[49] Assays of dynamics, mechanisms, and regulation of ATP transport and release: Implications for study of ABC transporter function

1998 • 9 citations

Hemodynamic characteristics of extracellular UTP in the perfused rat liver

1996 • 3 citations

Regulated release of ATP from human hepatocytes plays a key role in cell volume homeostasis

1998 • 3 citations