Curcumin Activates Defensive Genes and Protects Neurons Against Oxidative Stress

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

2004 • 2,165 citations

Pharmacology ofCurcuma longa

1991 • 1,684 citations

Role of Free Radicals in the Neurodegenerative Diseases

2001 • 1,490 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

1999 • 1,233 citations

Phase I Clinical Trial of Oral Curcumin

2004 • 1,170 citations

Nitric Oxide Scavenging by Curcuminoids

1997 • 1,127 citations

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

2003 • 989 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress

2000 • 834 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Regulation of Heme Oxygenase-1 Expression through the Phosphatidylinositol 3-Kinase/Akt Pathway and the Nrf2 Transcription Factor in Response to the Antioxidant Phytochemical Carnosol

2004 • 681 citations

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

2001 • 568 citations

Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology

2001 • 508 citations

Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models

2004 • 457 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

Progress in Cancer Chemoprevention: Development of Diet-Derived Chemopreventive Agents

2000 • 450 citations

Nutritional approaches to combat oxidative stress in Alzheimer’s disease

2002 • 399 citations

Nutritional genomics: the next frontier in the postgenomic era

2004 • 356 citations

Neurons Overexpressing Heme Oxygenase‐1 Resist Oxidative Stress‐Mediated Cell Death

2000 • 351 citations

Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers

2002 • 322 citations

Scavenging effect of extracts of green tea and natural antioxidants on active oxygen radicals

1989 • 318 citations

Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress

2000 • 300 citations

Incidence of Alzheimer’s disease in a rural community in India

2001 • 277 citations

Phenolic antioxidants from herbs and spices

2000 • 247 citations

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

1999 • 245 citations

Inhibitory effects of curcumin on tumorigenesis in mice

1997 • 229 citations

Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 Cells

2002 • 193 citations

Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer's Disease

2000 • 182 citations

Manganese complexes of curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity

2003 • 178 citations

Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes.

2004 • 176 citations

Ethyl Ferulate, a Lipophilic Polyphenol, Induces HO-1 and Protects Rat Neurons Against Oxidative Stress

2004 • 168 citations

Curcumin Suppresses Lipopolysaccharide-Induced Cyclooxygenase-2 Expression by Inhibiting Activator Protein 1 and Nuclear Factor κB Bindings in BV2 Microglial Cells

2004 • 168 citations

Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury

1999 • 157 citations

The heme oxygenase system and its functions in the brain.

2000 • 157 citations

Gene expression profiles of heme oxygenase isoforms in the rat brain

2002 • 154 citations

Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.

1992 • 151 citations

Protective effect of curcumin against lead neurotoxicity in rat

2003 • 145 citations

AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1

2000 • 110 citations

Differential Activation of Heme Oxygenase-1 by Chalcones and Rosolic Acid in Endothelial Cells

2004 • 101 citations

Regional distribution of heme oxygenase, HSP70, and glutathione in brain: Relevance for endogenous oxidant/antioxidant balance and stress tolerance

2002 • 99 citations

Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India

1998 • 96 citations

Directed establishment of rat brain cell lines with the phenotypic characteristics of type 1 astrocytes.

1992 • 89 citations

Long‐term Induction of Haem Oxygenase‐1 (HSP‐32) in Astrocytes and Microglia Following Transient Focal Brain Ischaemia in the Rat

1996 • 88 citations

Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells

2001 • 84 citations

Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells

2001 • 55 citations

Human heme oxygenase: Cell cycle-dependent expression and DNA microarray identification of multiple gene responses after transduction of endothelial cells

2003 • 53 citations

Inhibition of lipoxygenase 1 by phosphatidylcholine micelles‐bound curcumin

1998 • 46 citations

Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription

2005 • 38 citations

Protective role of heme oxygenase‐1 in oxidative stress‐induced neuronal injury

1999 • 12 citations