Immunopathogenesis of the multiple sclerosis lesion

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Axonal damage in acute multiple sclerosis lesions

1997 • 1,543 citations

Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis

2000 • 1,497 citations

Update on the Autoimmune Pathology of Multiple Sclerosis: B-Cells as Disease-Drivers and Therapeutic Targets

2015 • 1,440 citations

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

1999 • 1,212 citations

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

2000 • 918 citations

Acute axonal injury in multiple sclerosis: Correlation with demyelination and inflammation

2000 • 889 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.

1995 • 611 citations

The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10-year follow-up

1998 • 483 citations

Accumulation of hypointense lesions ("black holes") on T ₁ spin-echo MRI correlates with disease progression in multiple sclerosis

1996 • 451 citations

A quantitative analysis of oligodendrocytes in multiple sclerosis lesions

1999 • 445 citations

Magnetization transfer changes in the normal appering white matter precede the appearance of enhancing lesions in patients with multiple sclerosis

1998 • 393 citations

The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: A serial diffusion MRI study

2000 • 314 citations

Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis

1999 • 297 citations

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

1998 • 285 citations

Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells.

1998 • 267 citations

Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions

1994 • 258 citations

Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine–enhancing magnetic resonance imaging lesions

1993 • 237 citations

Comparison of MS clinical phenotypes using conventional and magnetization transfer MRI

1999 • 234 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.

1990 • 234 citations

Spinal cord atrophy and disability in MS

1998 • 230 citations

Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis

2000 • 220 citations

Progressive cerebral atrophy in MS

2000 • 218 citations

Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment

2000 • 218 citations

Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease

1999 • 217 citations

Expansion of Autoreactive T Cells in Multiple Sclerosis Is Independent of Exogenous B7 Costimulation

1998 • 193 citations

Resistance to Apoptosis and Elevated Expression of Bcl-2 in Clonally Expanded CD4+CD28− T Cells from Rheumatoid Arthritis Patients

1998 • 192 citations

In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis

1999 • 181 citations

Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients

1999 • 162 citations

In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity

2000 • 161 citations

Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.

1998 • 156 citations

Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease

1996 • 140 citations

Cutting Edge: Predictable TCR Antigen Recognition Based on Peptide Scans Leads to the Identification of Agonist Ligands with No Sequence Homology

1998 • 118 citations

Multisequence MRI in clinically isolated syndromes and the early development of MS

1999 • 114 citations

Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation

2000 • 101 citations

Spatial mapping of T2 and gadolinium-enhancing T1 lesion volumes in multiple sclerosis: evidence for distinct mechanisms of lesion genesis?

1999 • 98 citations

Increased numbers of CCR5+ interferon-?- and tumor necrosis factor-?-secreting T lymphocytes in multiple sclerosis patients

2000 • 89 citations

Insulin-like growth factor-I given subcutaneously reduces clinical deficits, decreases lesion severity and upregulates synthesis of myelin proteins in experimental autoimmune encephalomyelitis

1996 • 64 citations

A high‐resolution three‐dimensional T₁‐weighted gradient echo sequence improves the detection of disease activity in multiple sclerosis

1996 • 48 citations