The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation

Coactivator and corepressor complexes in nuclear receptor function

1999 • 909 citations

Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: Activation of the cross-linking by calcium ions

1979 • 792 citations

The cornified envelope of terminally differentiated human epidermal keratinocytes consists of cross-linked protein

1977 • 532 citations

Keratinocyte-specific transglutaminase of cultured human epidermal cells: Relation to cross-linked envelope formation and terminal differentiation

1985 • 479 citations

Structure and evolution of the human involucrin gene

1986 • 393 citations

The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation

1997 • 370 citations

Involucrin synthesis and tissue assembly by keratinocytes in natural and cultured human epithelia.

1981 • 351 citations

The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.

1989 • 318 citations

Isolation and characterization of fra-2, an additional member of the fos gene family.

1990 • 274 citations

Involucrin Expression in Normal and Neoplastic Human Skin: A Marker for Keratinocyte Differentiation

1984 • 210 citations

Unique TATA-binding protein-containing complexes and cofactors involved in transcription by RNA polymerases II and III.

1993 • 206 citations

Direct Evidence That Involucrin Is a Major Early Isopeptide Cross-linked Component of the Keratinocyte Cornified Cell Envelope

1997 • 200 citations

Difference in transcriptional regulatory function between c-Fos and Fra-2

1991 • 194 citations

Fos-related Antigen (Fra-1), junB, and junD Activate Human Involucrin Promoter Transcription by Binding to Proximal and Distal AP1 Sites to Mediate Phorbol Ester Effects on Promoter Activity

1995 • 183 citations

The Epidermis: Genes On – Genes Off

1997 • 181 citations

p300 Collaborates with Sp1 and Sp3 in p21 / Promoter Activation Induced by Histone Deacetylase Inhibitor

2000 • 169 citations

Transcription of the Human Loricrin Gene In Vitro Is Induced by Calcium and Cell Density and Suppressed by Retinoic Acid

1991 • 168 citations

Regulation of Human Involucrin Promoter Activity by a Protein Kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 Signal Transduction Pathway

1998 • 149 citations

Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice.

1993 • 141 citations

Highly Active Soluble Processed Forms of the Transglutaminase 1 Enzyme in Epidermal Keratinocytes

1995 • 117 citations

Loricrin Expression Is Coordinated with Other Epidermal Proteins and the Appearance of Lipid Lamellar Granules in Development

1995 • 106 citations

The Proximal Promoter of the Mouse Loricrin Gene Contains a Functional AP-1 Element and Directs Keratinocyte-specific but Not Differentiation-specific Expression

1995 • 92 citations

Tissue-specific and differentiation-appropriate expression of the human involucrin gene in transgenic mice: an abnormal epidermal phenotype

1993 • 89 citations

Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element.

1994 • 88 citations

Regulation of Human Involucrin Promoter Activity by Novel Protein Kinase C Isoforms

2000 • 83 citations

Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization

1991 • 82 citations

Requirement of an AP-1 Site in the Calcium Response Region of the Involucrin Promoter

2000 • 81 citations

Characterization of human involucrin promoter distal regulatory region transcriptional activator elements–a role for Sp1 and AP1 binding sites

1998 • 78 citations

Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. Fundamental role of an AP-1 element.

1994 • 77 citations

Expression patterns of loricrin in various species and tissues

1993 • 75 citations

Identification of control elements 3' to the human keratin 1 gene that regulate cell type and differentiation-specific expression.

1993 • 63 citations

The Distal Regulatory Region of the Human Involucrin Promoter Is Required for Expression in Epidermis

1998 • 59 citations

Identification of a Calcium-Inducible, Epidermal-Specific Regulatory Element in the 3'-Flanking Region of the Human Keratin 1 Gene

1993 • 55 citations

Regulation of Human Involucrin Promoter Activity by POU Domain Proteins

1996 • 51 citations

Analysis of the 5'-Upstream Promoter Region of Human Involucrin Gene: Activation by 12-O-Tetradecanoylphorbol-13-Acetate

1993 • 51 citations

AP-1 Activity during Normal Human Keratinocyte Differentiation: Evidence for a Cytosolic Modulator of AP-1/DNA Binding

1993 • 51 citations

Expression of the carcinoma-associated keratin K6 and the role of AP-1 proto-oncoproteins.

1993 • 50 citations

Transcription factor Sp1 activates involucrin promoter activity in non-epithelial cell types

1999 • 49 citations

Regulation of the Transglutaminase I Gene

1999 • 40 citations

In vitro Cross-Linking of Recombinant Human Involucrin

1998 • 29 citations

The α and η Isoforms of Protein Kinase C Stimulate Transcription of Human Involucrin Gene

1998 • 27 citations

A Dual Role for Involucrin in the Epidermis—Ultrastructural Localization in Epidermis and Hair Follicle in Humans and Transgenic Mice

1993 • 24 citations

Reply

1980 • 2 citations

CALENDAR OF EVENTS

1995 • 1 citations