pH, isotope, and substituent effects on the interconversion of aromatic substrates catalyzed by hydroxybutyrimidylated liver alcohol dehydrogenase

The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equations

1963 • 2,095 citations

4 Lactate Dehydrogenase

1975 • 1,272 citations

Reductive alkylation of amino groups in proteins

1968 • 678 citations

The Chemical Kinetics of Enzyme Action

1959 • 632 citations

1 Steady State Kinetics

1970 • 521 citations

The Reduction of Acid Amides with Lithium Aluminum Hydride

1953 • 293 citations

Kinetic Studies of Liver Alcohol Dehydrogenase and pH Effects with Coenzyme Preparations of High Purity

1963 • 158 citations

Mechanistic studies on equine liver alcohol dehydrogenase. I. Stoichiometry relation of the coenzyme binding sites to the catalytic sites active in the reduction of aromatic aldehydes in the transient state

1970 • 139 citations

Enhancement of the Activity of Horse Liver Alcohol Dehydrogenase by Modification of Amino Groups at the Active Sites

1970 • 132 citations

The Mechanism of Enzyme-catalyzed Reduced Nicotinamide Adenine Dinucleotide-dependent Reductions

1972 • 114 citations

The Effect of Substituents on the Deacylation of Benzoyl-Chymotrypsins

1962 • 113 citations

Roles of zinc ion and reduced coenzyme in the formation of a transient chemical intermediate during the equine liver alcohol dehydrogenase catalyzed reduction of an aromatic aldehyde

1973 • 101 citations

Isotope effects and structure-reactivity correlations in the yeast alcohol dehydrogenase reaction. A study of the enzyme-catalyzed oxidation of aromatic alcohols

1976 • 99 citations

Proton equilibriums and kinetics in the liver alcohol dehydrogenase reaction mechanism

1974 • 93 citations

Dissociation Constants of the Binary Complex of Homogeneous Horse Liver Alcohol Dehydrogenase and Nicotiniumamide Adenine Dinucleotide.

1967 • 84 citations

Diphosphopyridine Nucleotide-Linked Aldehyde Dehydrogenase

1962 • 82 citations

Kinetic Studies with Liver Alcohol Dehydrogenase^*

1965 • 80 citations

Structural comparisons of mammalian, yeast and bacillar alcohol dehydrogenases

1976 • 76 citations

Substrate activation and inhibition in coenzyme-substrate reactions cyclohexanol oxidation catalysed by liver alcohol dehydrogenase

1966 • 75 citations

[127] Enzymatic preparation of DPNH and TPNH

1957 • 74 citations

Nuclear magnetic resonance studies of substrate interaction with cobalt substituted alcohol dehydrogenase from liver

1975 • 73 citations

Catalytic steps during the single-turnover reduction of aldehydes by alcohol dehydrogenase

1972 • 69 citations

Mechanisms of zinc ion catalysis in small molecules and enzymes

2007 • 66 citations

Roles of zinc ion and reduced coenzyme in horse liver alcohol dehydrogenase catalysis. Mechanism of aldehyde activation

1975 • 64 citations

Some observations on the preparation and properties of dihydronicotinamide-adenine dinucleotide

1962 • 62 citations

Chemical reactivities of catalytic and noncatalytic zinc or cobalt atoms of horse liver alcohol dehydrogenase: differentiation by their thermodynamic and kinetic properties.

1976 • 61 citations

The Effects of pH and Temperature on Hydrogen Transfer in the Liver Alcohol Dehydrogenase Mechanism

1972 • 61 citations

Kinetics of native and activated isozymes of horse liver alcohol dehydrogenase

1977 • 58 citations

Horse Liver Alcohol Dehydrogenase

1973 • 56 citations

Electronic substituent effects during the liver alcohol dehydrogenase catalyzed reduction of aromatic aldehydes

1974 • 53 citations

Use of Substituent Effects on Isotope Effects to Distinguish between Proton and Hydride Transfers. Part I. Mechanism of Oxidation of Alcohols by Bromine in Water^1-3

1961 • 52 citations

The Reaction of Aromatic Aldehydes with n-Butylamine. Acid Catalysis and Substituent Effects¹

1958 • 50 citations

1 Kinetics and Mechanism of Nicotinamide-Nucleotid-Linked Dehydrogenases

1975 • 49 citations

Activity of liver alcohol dehydrogenase with various substituents on the amino groups

1974 • 44 citations

The half-of-the-sites reactivity of horse liver alcohol dehydrogenase in the presence of alcohol substrates

1974 • 44 citations

Acid-base catalysis in the yeast alcohol dehydrogenase reaction.

1975 • 43 citations

Deuterium isotope effects on initial rates of the liver alcohol dehydrogenase reaction. V

1973 • 42 citations

Identification of the lysine residue modified during the activation by acetimidylation of horse liver alcohol dehydrogenase

1975 • 42 citations

Structure-activity relation in benzamides inhibiting alcohol dehydrogenase

1973 • 40 citations

Effect of pH on the liver alcohol dehydrogenase reaction

1975 • 39 citations

On the kinetic distinction of ordered and random bireactant enzyme systems

1976 • 37 citations

Activation and inactivation of horse liver alcohol dehydrogenase with pyridoxal compounds.

1975 • 36 citations

Comparison of the kinetics and stoichiometry of proton uptake with aldehyde reduction for liver alcohol dehydrogenase under single turnover conditions

1974 • 33 citations

Substituent Effects on the Pre‐Steady‐State Kinetics of Oxidation of Benzyl Alcohols by Liver Alcohol Dehydrogenase

1974 • 23 citations

Effect of Substrate Structure on the Pre‐Steady‐State Kinetics of Oxidation by Liver Alcohol Dehydrogenase

1975 • 23 citations

Electronic Effects in Horse Liver Alcohol Dehydrogenase Catalysis.

1966 • 23 citations

Studies of thiaminase action: Hammett's ϱσ treatment

1963 • 20 citations

Notes - Carbonyl Reactions. III. The Formation of Aromatic Semicarbazones. A Nonlinear Rho-Sigma Correlation

1958 • 19 citations

Activation of liver alcohol dehydrogenases by imidoesters generated in solution

1975 • 19 citations

Electronic Effects and L-Amino-Acid Oxidase Specificity

1964 • 17 citations

Liver alcohol dehydrogenase: Evidence for a new cobalt/zinc hybrid

1976 • 10 citations