Arteries and veins: making a difference with zebrafish

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

In Vivo Imaging of Embryonic Vascular Development Using Transgenic Zebrafish

2002 • 2,055 citations

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

1998 • 1,663 citations

Vasculogenesis

1995 • 1,344 citations

Notch signaling is essential for vascular morphogenesis in mice

2000 • 1,042 citations

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

1999 • 1,019 citations

Notch signaling is required for arterial-venous differentiation during embryonic vascular development

2001 • 899 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

1996 • 866 citations

The Vascular Anatomy of the Developing Zebrafish: An Atlas of Embryonic and Early Larval Development

2001 • 839 citations

sonic hedgehog and vascular endothelial growth factor Act Upstream of the Notch Pathway during Arterial Endothelial Differentiation

2002 • 806 citations

Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

1999 • 756 citations

Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

1999 • 708 citations

Sensory Nerves Determine the Pattern of Arterial Differentiation and Blood Vessel Branching in the Skin

2002 • 635 citations

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

2001 • 609 citations

Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo

1996 • 606 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

Gridlock signalling pathway fashions the first embryonic artery

2001 • 552 citations

Dll4, a novel Notch ligand expressed in arterial endothelium

2000 • 522 citations

Mutations affecting somite formation and patterning in the zebrafish, Danio rerio

1996 • 513 citations

The cloche and spadetail Genes Differentially Affect Hematopoiesis and Vasculogenesis

1998 • 508 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms

2002 • 492 citations

Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny

1989 • 460 citations

Studies on the origin of blood vessels and of red corpuscles as seen in the living blastoderm of the chick during the second day of incubation

1920 • 457 citations

Universal GFP reporter for the study of vascular development

2000 • 445 citations

Mutations affecting the cardiovascular system and other internal organs in zebrafish

1996 • 441 citations

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

2000 • 438 citations

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels

2001 • 433 citations

gridlock , an HLH Gene Required for Assembly of the Aorta in Zebrafish

2000 • 427 citations

Use of the Gal4-UAS technique for targeted gene expression in the zebrafish

1999 • 387 citations

Disruption ofacvrl1increases endothelial cell number in zebrafish cranial vessels

2002 • 364 citations

Ephrin-B2 Selectively Marks Arterial Vessels and Neovascularization Sites in the Adult, with Expression in Both Endothelial and Smooth-Muscle Cells

2001 • 362 citations

Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish

1998 • 355 citations

Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms

2002 • 347 citations

Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)

2002 • 335 citations

gridlock, a localized heritable vascular patterning defect in the zebrafish

1995 • 323 citations

Expression of EphrinB2 Identifies a Stable Genetic Difference Between Arterial and Venous Vascular Smooth Muscle as Well as Endothelial Cells, and Marks Subsets of Microvessels at Sites of Adult Neovascularization

2001 • 308 citations

Vessel Patterning in the Embryo of the Zebrafish: Guidance by Notochord

1997 • 302 citations

Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio

1996 • 302 citations

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

2001 • 290 citations

The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation

1997 • 290 citations

Vasculogenesis and angiogenesis: Two distinct morphogenetic mechanisms establish embryonic vascular pattern

1989 • 288 citations

The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis

1997 • 287 citations

Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos

2000 • 257 citations

Distinct Requirements for Zebrafish Angiogenesis Revealed by aVEGF-AMorphant

2000 • 256 citations

Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development

1992 • 253 citations

An instructive function for Notch in promoting gliogenesis in the zebrafish retina

2001 • 244 citations

Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo

2001 • 235 citations

Mutations affecting the formation of the notochord in the zebrafish, Danio rerio

1996 • 232 citations

Members of the HRT family of basic helix–loop–helix proteins act as transcriptional repressors downstream of Notch signaling

2000 • 231 citations

A Gene Expression Screen in Zebrafish Embryogenesis

2001 • 227 citations

Studies on the growth of blood‐vessels in the tail of the frog larva—by observation and experiment on the living animal

1918 • 195 citations

The eph receptor family:axonal guidance by contact repulsion

1997 • 190 citations

An Antisense Oligonucleotide to the Notch Ligand Jagged Enhances Fibroblast Growth Factor-induced Angiogenesis in Vitro

1996 • 147 citations

The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis

2000 • 131 citations

Vasculogenesis in the chick embryo. An ultrastructural study

1971 • 114 citations

Cloning and characterization of vascular endothelial growth factor (VEGF) from zebrafish, Danio rerio

1998 • 102 citations

Arterial pressure in the chick embryo

1973 • 96 citations

Arterial Identity of Endothelial Cells Is Controlled by Local Cues

2001 • 93 citations

tbx20 , a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish

2000 • 87 citations

Sequence and embryonic expression of deltaC in the zebrafish

2000 • 86 citations

Herophilus of Alexandria (325-255 B. C.)

1998 • 73 citations

Molecular Mechanisms of Vascular Development

1999 • 48 citations

The ultrastructure of human umbilical vessel endothelium from early pregnancy to full term.

1972 • 44 citations

Movement of the Heart and Blood in Animals: An Anatomical Essay

1958 • 28 citations