Confocal Microscopy Reveals Thimet Oligopeptidase (EC 3.4.24.15) and Neurolysin (EC 3.4.24.16) in the Classical Secretory Pathway

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

1991 • 589 citations

Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway.

1992 • 463 citations

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum‐Golgi complex

1992 • 461 citations

Syntaxin 6 functions in trans-Golgi network vesicle trafficking.

1997 • 286 citations

Identification and Characterization of a Nerve Terminal-enriched Amphiphysin Isoform

1997 • 176 citations

Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway

1993 • 175 citations

Proteolytic Processing of Pro-ACTH/Endorphin Begins in the Golgi Complex of Pituitary Corticotropes and AtT-20 Cells

1989 • 165 citations

Tripeptidyl peptidases: enzymes that count

1999 • 145 citations

Synaptosomal Membrane‐Bound Form of Endopeptidase‐24.15 Generates Leu‐Enkephalin from Dynorphin _1‐8, α‐ and β‐Neoendorphin, and Met‐Enkephalin from Met‐Enkephalin‐Arg⁶‐Gly⁷‐Leu

1987 • 125 citations

Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.

1992 • 109 citations

[32] Thimet oligopeptidase and oligopeptidase M or neurolysin

1995 • 100 citations

Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype.

1994 • 91 citations

Neuropeptide Specificity and Inhibition of Recombinant Isoforms of the Endopeptidase 3.4.24.16 Family: Comparison with the Related Recombinant Endopeptidase 3.4.24.15

1998 • 88 citations

Endopeptidases 24.16 and 24.15 Are Responsible for the Degradation of Somatostatin, Neurotensin, and Other Neuropeptides by Cultivated Rat Cortical Astrocytes

1994 • 84 citations

Molecular Cloning and Expression of Rat Brain Endopeptidase 3.4.24.16

1995 • 73 citations

Distinct Properties of Neuronal and Astrocytic Endopeptidase 3.4.24.16: A Study on Differentiation, Subcellular Distribution, and Secretion Processes

1996 • 70 citations

Structural features that make oligopeptides susceptible substrates for hydrolysis by recombinant thimet oligopeptidase

1997 • 62 citations

Proteolytic Processing of Pro-opiomelanocortin Occurs in Acidifying Secretory Granules of AtT-20 Cells

1997 • 60 citations

Immunocytochemical localization of endopeptidase 24.15 in rat brain

1992 • 57 citations

Secretion of Metalloendopeptidase 24.15 (EC 3.4.24.15)

1999 • 54 citations

Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain

1999 • 52 citations

PC5-A-mediated Processing of Pro-neurotensin in Early Compartments of the Regulated Secretory Pathway of PC5-transfected PC12 Cells

1998 • 50 citations

Targeting of Endopeptidase 24.16 to Different Subcellular Compartments by Alternative Promoter Usage

1997 • 49 citations

Membrane translocation of proteins without hydrophobic signal peptides

1990 • 48 citations

The tissue-specific processing of Pro-ACTH/Endorphin recent advances and unsolved problems

1990 • 42 citations

Colocalization of neurotensin receptors and of the neurotensin- degrading enzyme endopeptidase 24-16 in primary cultures of neurons

1990 • 38 citations

Localization of Endo‐Oligopeptidase (EC 3.4.22.19) in the Rat Nervous Tissue

1990 • 37 citations

Effect of a novel selective and potent phosphinic peptide inhibitor of endopeptidase 3.4.24.16 on neurotensin‐induced analgesia and neuronal inactivation

1997 • 36 citations

Contribution of endopeptidase 3.4.24.15 to central neurotensin inactivation

1997 • 36 citations

Light and Electron Microscopic Localization of the Neutral Metalloendopeptidase EC 3.4.24.16 in the Mesencephalon of the Rat

1992 • 33 citations

Secretion of a Neuropeptide-Metabolizing Enzyme Similar to Endopeptidase 22.19 by Glioma C6-Cells

1993 • 32 citations

Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies

1989 • 26 citations

Endooligopeptidase A activity in rabbit heart: Generation of enkephalin from enkephalin containing peptides

1988 • 22 citations

Stably Transfected Human Cells Overexpressing Rat Brain Endopeptidase 3.4.24.16: Biochemical Characterization of the Activity and Expression of Soluble and Membrane‐Associated Counterparts

1997 • 21 citations

[17] Strategies for characterizing, cloning, and expressing soluble endopeptidases

1995 • 16 citations

Monoclonal Antibodies Against the Human Metalloprotease EC 3.4.24.15 Label Neurofibrillary Tangles in Alzheimer's Disease Brain

1996 • 15 citations

Endo‐Oligopeptidase A., a Putative Enkephalin‐Generating Enzyme, in the Vertebrate Retina

1991 • 13 citations

[21] Identification and distribution of endopeptidase 24.16 in central nervous system

1995 • 13 citations

Role of calcium in the release of EC 3.4.24.15 and EC 3.4.24.16 from endothelial cells

1999 • 3 citations