Inhibitors of the enkephalin degrading enzymes Modulation of activity of hydroxamate containing compounds by modifications of the C‐terminal residue

PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE

1957 • 1,523 citations

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.

1976 • 706 citations

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

1978 • 652 citations

Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

1987 • 238 citations

Molecular cloning and amino acid sequence of rat enkephalinase

1987 • 190 citations

Inhibition of enkepha,in metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor

1983 • 139 citations

Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site.

1988 • 119 citations

Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin

1986 • 110 citations

The μ rather than the δ subtype of opioid receptors appears to be involved in enkephalin-induced analgesia

1984 • 95 citations

Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan.

1983 • 86 citations

Exploration of the catalytic site of endopeptidase 24.11 by site‐directed mutagenesis Histidine residues 583 and 587 are essential for catalysis

1988 • 86 citations

New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties

1985 • 82 citations

Primary structure homologies between two zinc metallopeptidases, the neutral endopeptidase 24.11 ("enkephalinase") and thermolysin, through clustering analysis

1988 • 66 citations

Differences in the structural requirements for selective interaction with neutral metalloendopeptidase (enkephalinase) or angiotensin-converting enzyme. Molecular investigation by use of new thiol inhibitors

1984 • 62 citations

Absolute steric course of hydrolysis by .alpha.-chymotrypsin. Esters of .alpha.-benzylsuccinic, .alpha.-methyl-.beta.-phenylpropionic, and .alpha.-methylsuccinic acids

1968 • 60 citations

Bidentate peptides: Highly potent new inhibitors of enkephalin degrading enzymes

1984 • 60 citations

Boron Tris(trifluoroacetate) for Removal of Protecting Groups in Peptide Chemistry

1973 • 51 citations

Relationship between the inhibitory potencies of thiorphan and retrothiorphan enantiomers on thermolysin and neutral endopeptidase 24.11 and their interactions with the thermolysin active site by computer modelling

1987 • 45 citations

Inhibition of enkephalin-degrading enzymes from rat brain and of thermolysin by amino acid hydroxamates

1981 • 44 citations

L-Leucinthiol — A potent inhibitor of leucine aminopeptidase

1983 • 43 citations

Comparison of dipeptidyl carboxypeptidase and endopeptidase activities in the three enkephalin-hydrolysing metallopeptidases: “Angiotensin-converting enzyme”, thermolysin and “enkephalinase”

1985 • 38 citations

The use of a monoclonal antibody for the rapid purification of kidney neutral endopeptidase ("enkephalinase") solubilized in octyl glucoside

1987 • 34 citations

Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes

1988 • 33 citations

Evidence for an essential histidine in neutral endopeptidase 24.11

1987 • 31 citations

Reaction of neutral endopeptidase 24.11 (enkephalinase) with arginine reagents.

1986 • 21 citations

Presence of a histidine at the active site of the neutral endopeptidase — 24.11

1986 • 21 citations

Irreversible photolabeling of active site of neutral endopeptidase-24.11 "enkephalinase" by azidothiorphan and [14C]-azidothiorphan.

1987 • 5 citations