AAV-Mediated Expression of Vascular Endothelial Growth Factor Induces Choroidal Neovascularization in Rat

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1989 • 2,267 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

Age-Related Macular Degeneration and Blindness due to Neovascular Maculopathy

1984 • 1,053 citations

Mutation of the Stargardt Disease Gene ( ABCR ) in Age-Related Macular Degeneration

1997 • 861 citations

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1996 • 855 citations

Age-related Macular Degeneration Histopathologic Studies

1993 • 747 citations

Recombinant adeno-associated virus for muscle directed gene therapy

1997 • 656 citations

Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1

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SENILE MACULAR DEGENERATION: A CASE-CONTROL STUDY

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Transdifferentiated Retinal Pigment Epithelial Cells are Immunoreactive for Vascular Endothelial Growth Factor in Surgically Excised AgeRelated Macular Degeneration-Related Choroidal Neovascular Membranes.

1998 • 590 citations

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

1999 • 556 citations

Intravitreous Injections of Vascular Endothelial Growth Factor Produce Retinal Ischemia and Microangiopathy in an Adult Primate

1996 • 516 citations

Polarized Vascular Endothelial Growth Factor Secretion by Human Retinal Pigment Epithelium and Localization of Vascular Endothelial Growth Factor Receptors on the Inner Choriocapillaris

1999 • 502 citations

Increased expression of angiogenic growth factors in age-related maculopathy

1997 • 497 citations

VEGF is major stimulator in model of choroidal neovascularization.

2000 • 430 citations

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

1999 • 416 citations

Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa

1998 • 406 citations

Synthesis and Secretion of Vascular Permeability Factor/Vascular Endothelial Growth Factor by Human Retinal Pigment Epithelial Cells

1993 • 392 citations

Retinal and choroidal neovascularization

2000 • 386 citations

Overexpression of Vascular Endothelial Growth Factor (VEGF) in the Retinal Pigment Epithelium Leads to the Development of Choroidal Neovascularization

2000 • 380 citations

Transgenic Mice with Increased Expression of Vascular Endothelial Growth Factor in the Retina: A New Model of Intraretinal and Subretinal Neovascularization.

1998 • 367 citations

Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Are Present in Epiretinal and Choroidal Neovascular Membranes

1996 • 358 citations

Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy

2002 • 336 citations

Targeted Disruption of the FGF2 Gene Does Not Prevent Choroidal Neovascularization in a Murine Model

1998 • 324 citations

Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

1998 • 320 citations

Histopathology of Age-Related Macular Degeneration

2007 • 313 citations

AAV vectors: is clinical success on the horizon?

2000 • 291 citations

Growth factor localization in choroidal neovascular membranes of age-related macular degeneration.

1994 • 286 citations

Adenovirus vector-mediated in vivo gene transfer into adult murine retina.

1994 • 239 citations

Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina

1999 • 239 citations

Intrachoroidal Neovascularization in Transgenic Mice Overexpressing Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium

2001 • 229 citations

Vascular endothelial growth factor expression in choroidal neovascularization in rats

1997 • 208 citations

Subretinal Neovascularization

1982 • 207 citations

Safety and Biological Efficacy of an Adeno‐Associated Virus Vector–Cystic Fibrosis Transmembrane Regulator (AAV‐CFTR) in the Cystic Fibrosis Maxillary Sinus

1999 • 206 citations

Effects of Intravitreal Administration of Steroids on Experimental Subretinal Neovascularization in the Subhuman Primate

1985 • 197 citations

Dramatic Inhibition of Retinal and Choroidal Neovascularization by Oral Administration of a Kinase Inhibitor

1999 • 171 citations

Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart

2000 • 164 citations

VEGF ₁₆₅ Expressed by a Replication-Deficient Recombinant Adenovirus Vector Induces Angiogenesis In Vivo

1995 • 159 citations

Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) Mice

1995 • 158 citations

Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2.

2000 • 152 citations

Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway

1997 • 150 citations

Vasculotropin/Vascular endothelial growth factor is an autocrine growth factor for human retinal pigment epithelial cells cultued in vitro

1995 • 146 citations

Vascular endothelial growth factor and ocular neovascularization.

1997 • 139 citations

Macular pigment and melanin in age-related maculopathy in a general population.

2002 • 131 citations

Choroidal neovascularization in the rat induced by adenovirus mediated expression of vascular endothelial growth factor.

2000 • 124 citations

Growth Factors in Age-Related Macular Degeneration: Pathogenic and Therapeutic Implications

1997 • 122 citations

Structure of Adeno-Associated Virus Vector DNA following Transduction of the Skeletal Muscle

1999 • 114 citations

AN ULTRASTRUCTURAL STUDY OF THE ROLE OF LEUCOCYTES AND FIBROBLASTS IN THE BREAKDOWN OF BRUCH'S MEMBRANE

1984 • 112 citations

The P2Y(2) receptor agonist INS37217 stimulates RPE fluid transport in vitro and retinal reattachment in rat.

2002 • 102 citations

Retinal pigment epithelial transport mechanisms and their contributions to the electroretinogram

1997 • 101 citations

Race, iris color, and age-related macular degeneration.

2000 • 100 citations

Regional Angiogenesis Induced in Nonischemic Tissue by an Adenoviral Vector Expressing Vascular Endothelial Growth Factor

1997 • 83 citations

Two Animal Models of Retinal Degeneration Are Rescued by Recombinant Adeno-associated Virus-Mediated Production of FGF-5 and FGF-18

2001 • 77 citations

Development of the blood-retinal barrier in vitro: Formation of tight junctions as revealed by occludin and ZO-1 correlates with the barrier function of chick retinal pigment epithelial cells

1995 • 69 citations

Remodeling of junctional complexes during the development of the outer blood-retinal barrier

1997 • 61 citations

Adeno-associated virus type 2 DNA replication in vivo: mutation analyses of the D sequence in viral inverted terminal repeats

1997 • 60 citations

Additional Transduction Events after Subretinal Readministration of Recombinant Adeno-Associated Virus

2000 • 53 citations

Efficient Expression of the Vascular Endothelial Growth Factor Gene In Vitro and In Vivo, Using an Adeno-associated Virus Vector

2001 • 50 citations

Kinetics of Recombinant Adeno-Associated Virus-Mediated Gene Transfer

2000 • 47 citations

Chapter 49 Experimental retinal detachment: a paradigm for understanding the effects of induced photoreceptor degeneration

2001 • 31 citations

Long‐term real‐time monitoring of adeno‐associated virus‐mediated gene expression in the rat retina

2000 • 23 citations