T Cells, the MHC, and Function

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.

1982 • 740 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

1982 • 600 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Clusters of genes encoding mouse transplantation antigens

1982 • 419 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

1982 • 306 citations

Fundamental immunology

1984 • 277 citations

EVIDENCE FOR A BLOOD-THYMUS BARRIER USING ELECTRON-OPAQUE TRACERS

1972 • 258 citations

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

1981 • 234 citations

The delineation of antigen receptors on human T lymphocytes

1983 • 162 citations

A Clonal Deletion Model for Ir Gene Control of the Immune Response

1978 • 156 citations

A one-receptor view of T-cell behaviour

1981 • 146 citations

Specificity of cytotoxic T cells from athymic mice.

1980 • 141 citations

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

1980 • 139 citations

Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens.

1980 • 138 citations

Antigen-driven helper cell-independent cloned cytolytic T lymphocytes

1981 • 128 citations

Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.

1979 • 122 citations

Structure of Class I Major Histocompatibility Antigens

1983 • 107 citations

Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells.

1983 • 104 citations

Characterization of a TL−variant of a homozygous TL+ mouse lymphoma

1976 • 101 citations

Allospecific and virus-specific cytolytic T lymphocytes are restricted to the N or C1 domain of H-2 antigens expressed on L cells after DNA-mediated gene transfer.

1983 • 92 citations

Thymic cytotoxic T lymphocytes are primed in vivo to minor histocompatibility antigens.

1984 • 76 citations

Lyt-2-/Lyt 3- variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis.

1981 • 74 citations

Mhc RESTRICTION AND Ir GENES

1982 • 73 citations

Intramolecular organization of Class I H-2 MHC antigens; localization of the alloantigenic determinants and the beta 2 m binding site to different regions of the H-2 Kb glycoprotein.

1983 • 70 citations

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.

1982 • 58 citations

The T-cell receptor mediating restrictive recognition of antigen

1983 • 57 citations

Aged murine killer T-cell clones acquire specific cytotoxicity for P815 mastocytoma cells

1984 • 56 citations

Tryptic peptide comparison of Ia antigen ? and ? polypeptides from the I-A Mutant B6.C-H-2 bm12 and its congenic parental strain B6

1981 • 55 citations

T cells may express multiple activities: specific allohelp, cytolysis, and delayed-type hypersensitivity are expressed by a cloned T-cell line.

1981 • 51 citations

The QA2 subregion controls the expression of two antigens recognized by H-2- unrestricted cytotoxic T cells

1982 • 45 citations

T lymphocyte-mediated cytolysis. II. Role of target cell histocompatibility antigens in recognition and lysis.

1981 • 41 citations

Cytolytic T lymphocyte precursor cells in congenitally athymic C57BL/6 nu/nu mice: quantitation, enrichment, and specificity.

1981 • 40 citations

Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by ?1 and ?2 but not ?3 external domains

1984 • 37 citations

The ability of H-2+ and H-2− cell lines to induce or be lysed by Cytotoxic T cells

1977 • 36 citations

Localized conformational changes induced in a class I major histocompatibility antigen by the binding of monoclonal antibodies.

1984 • 36 citations

Interleukin 2 production by lymphoid cells from congenitally athymic (nu/nu) mice.

1982 • 35 citations

Cytolytic T lymphocyte clones that proliferate autonomously to specific alloantigenic stimulation. II. Relationship of the Lyt-2 molecular complex to cytolytic activity, proliferation, and lymphokine secretion.

1983 • 32 citations

Ia-positive stimulator cells are required in primary, but not in secondary, mixed leukocyte reactions against H-2K and H-2D differences.

1981 • 31 citations

Characterization of an Lyt‐l+ Cytolytic T‐Cell Clone Specific for a Polymorphic Domain of the I‐A^k Molecule

1982 • 27 citations

Responses to the H–2Kba mutant involve recognition of syngeneic Ia molecules

1983 • 26 citations

Transformation of LMTK- cells with purified class I genes. V. Antibody-induced structural modification of HLA class I molecules results in potentiation of the fixation of a second monoclonal antibody.

1984 • 22 citations

Monoclonal anti-Lyt-2 antibodies block the activation of cytolytic T lymphocyte precursors.

1983 • 21 citations

Significance of class 1 and class 2 major histocompatibility complex antigens: help to allogeneic K and D antigens does not involve I recognition.

1981 • 20 citations

Nonresponsiveness to the male antigen H-Y in H-2 I-A-mutant B6.C-H-2bm12 is not caused by defective antigen presentation.

1983 • 19 citations

T‐Cell Receptor Idiotypes

1980 • 18 citations

The role of T cell subsets in the generation of secondary cytolytic responses in vitro against class I and class II major histocompatibility complex antigens.

1984 • 17 citations

Monoclonal antibody to Lyt 2 antigen blocks H–2I- and H–2K- specific mouse cytotoxic T cells

1982 • 17 citations

Functional T cell subsets defined by monoclonal antibodies

1983 • 14 citations

A random repertoire of V genes for T-cell receptors? Theoretical implications of recent experimental observations on T-cell specificity and self-restriction

1981 • 11 citations