Core promoter mutations (A₁₇₆₂T and G₁₇₆₄A) and viral genotype in chronic hepatitis B and hepatocellular carcinoma in Guangxi, China

Basic local alignment search tool

1990 • 87,358 citations

MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION

1989 • 1,210 citations

Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes

1988 • 1,057 citations

Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B

2000 • 940 citations

A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness

2000 • 923 citations

Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

1990 • 578 citations

Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen

1994 • 493 citations

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication

1996 • 474 citations

Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan

2001 • 418 citations

A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C

2001 • 400 citations

Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.

1994 • 375 citations

Core Promoter Mutations and Genotypes in Relation to Viral Replication and Liver Damage in East Asian Hepatitis B Virus Carriers

1999 • 304 citations

Hepatitis B Virus Strains with Mutations in the Core Promoter in Patients with Fulminant Hepatitis

1995 • 292 citations

Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region

1993 • 266 citations

High prevalence of 1762T 1764A mutations in the basic core promoter of hepatitis B virus isolated from black africans with hepatocellular carcinoma compared with asymptomatic carriers

1999 • 258 citations

Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis B e antigen

1989 • 229 citations

The precore/core promoter mutant (T1762A1764) of hepatitis B virus: clinical significance and an easy method for detection

1995 • 205 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

Aflatoxins and Fumonisins in Corn from the High-Incidence Area for Human Hepatocellular Carcinoma in Guangxi, China

2001 • 177 citations

Hepatitis B Virus Genotype Distribution among Chronic Hepatitis B Virus Carriers in Shanghai, China

2001 • 177 citations

Precore mutant hepatitis B virus infection and liver disease

1992 • 173 citations

Association of a precore genomic variant of hepatitis B virus with fulminant hepatitis

1991 • 169 citations

Biologic Properties of Hepatitis B Viral Genomes with Mutations in the Precore Promoter and Precore Open Reading Frame

1997 • 163 citations

A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

1996 • 133 citations

Comparative immunogenicity of hepatitis B virus core and E antigens.

1988 • 117 citations

Hepatitis B virus X gene 1751 to 1764 mutations: implications for HBeAg status and disease.

1997 • 106 citations

Hepatocyte-Specific Expression of the Hepatitis B Virus Core Promoter Depends on Both Positive and Negative Regulation

1993 • 89 citations

Fatal Reactivation of Precore Mutant Hepatitis B Virus Associated with Fibrosing Cholestatic Hepatitis after Bone Marrow Transplantation

1994 • 89 citations

FULMINANT HEPATITIS B IN SUCCESSIVE FEMALE SEXUAL PARTNERS OF TWO ANTI-HBe-POSITIVE MALES

1986 • 66 citations

HBV core promoter mutations prevail in patients with hepatocellular carcinoma from Guangxi, China

1998 • 57 citations

Hepatitis B virus sequence changes evolving in liver transplant recipients with fulminant hepatitis

1997 • 56 citations

Deletion Mutants of the Hepatitis B Virus X Gene in Human Hepatocellular Carcinoma

1997 • 55 citations

Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan

1998 • 55 citations

Fibrosing cholestatic hepatitis in a transplant recipient with hepatitis B virus precore mutant

1993 • 53 citations

A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant

1995 • 51 citations

Hepatocyte-specific expression of the hepatitis B virus core promoter depends on both positive and negative regulation.

1993 • 48 citations

Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant

1995 • 35 citations

Analysis of the precore and core promoter DNA sequence in liver tissues from tients with hepatocellular carcinoma

1999 • 29 citations

Sequential analyses of the mutations in the core upstream and precore regions of hepatitis B virus genome in anti-HBe positive-carriers developing acute exacerbation.

1997 • 29 citations

Three Sites of the Hepatitis B Virus X Protein Cooperatively Interact with Cellular Proteins

1994 • 28 citations

Transactivating function and expression of the x gene of hepatitis B virus

1995 • 28 citations

Selection of a precore mutant after vertical transmission of different hepatitis B virus variants is correlated with fulminant hepatitis in infants

1995 • 26 citations

Functional Analysis of Hepatitis B Virus Transactivator X: Implication of the Leucine Zipper-like Region and C-Terminal Seven Conserved Amino Acids in Functional Regions

1993 • 24 citations

Sequential analyses of the mutations in the core upstream and precore regions of hepatitis B virus genome in anti-HBe positive-carriers developing acute exacerbation

1997 • 23 citations

Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma

2000 • 19 citations

Precore Mutant Hepatitis B Virus and Outcome of Chronic Infection and Hepatitis in Hepatitis B e Antigen-Positive Children

1994 • 18 citations

Association between Hepatitis B Virus Core Promoter Rearrangements and Hepatocellular Carcinoma

1998 • 18 citations

[Distribution of viral hepatitis B infection in Guangsi Province].

1982 • 8 citations

[Epidemiological study on relationship between hepatitis B and liver cancer--a prospective study on development of liver cancer and distribution of HBsAg carriers and liver damage persons in Guangxi].

1988 • 6 citations

[The aflatoxins and liver cancer in Guangxi, China].

1992 • 4 citations

[The study of the relationship between diet and primary liver cancer].

1991 • 4 citations

Reply

2001 • 2 citations