Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

1993 • 822 citations

New rules of selectivity: allylic alkylations catalyzed by palladium

1980 • 626 citations

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

1995 • 546 citations

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

1994 • 526 citations

Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90)

1994 • 351 citations

Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease

1996 • 209 citations

Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere

1993 • 175 citations

Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors

1994 • 148 citations

Kynostatin (KNI-227 and -272, highly potent anti-HIV agents: conformationally constrained tripeptide inhibitors of HIV protease containing allophenylnorstatine.

1992 • 146 citations

Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol

1993 • 131 citations

The HIV-1 Protease as Enzyme and Substrate: Mutagenesis of Autolysis Sites and Generation of a Stable Mutant with Retained Kinetic Properties

1994 • 130 citations

Substrate analog inhibition and active site titration of purified recombinant HIV-1 protease

1990 • 127 citations

Crystal structures of HIV-1 protease-inhibitor complexes

1993 • 120 citations

Analysis of the signals for transcription termination by purified RNA polymerase II

1990 • 113 citations

Recent advances in the design of HIV proteinase inhibitors

1992 • 97 citations

A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs

1994 • 87 citations

Human immunodeficiency virus protease: A target for aids therapy

1990 • 83 citations

The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

1990 • 75 citations

The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors

1993 • 74 citations

Drug discovery technologies

1990 • 73 citations

Cholinergic activity of acetylenic imidazoles and related compounds

1991 • 58 citations

Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors

1995 • 58 citations

Design of orally bioavailable, symmetry-based inhibitors of HIV protease

1994 • 55 citations

Competitive Inhibition of HIV-1 Protease by 4-Hydroxy-benzopyran-2-ones and by 4-Hydroxy-6-phenylpyran-2-ones

1994 • 39 citations

Competitive Inhibition of HIV-1 Protease by Warfarin Derivatives

1994 • 38 citations

Chemical graphics input/output package for the cambridge structural database

1988 • 23 citations

CD4 defect without HIV in patients with opportunistic infections of Kaposiʼs sarcoma131

1993 • 8 citations

Deleted Work

1955 • 0 citations