The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 Å Resolution

1989 • 683 citations

Design, Activity, and 2.8 Å Crystal Structure of a C ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

1990 • 524 citations

MERLOT, an integrated package of computer programs for the determination of crystal structures by molecular replacement

1988 • 348 citations

X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

1990 • 274 citations

A method of positioning a known molecule in an unknown crystal structure

1967 • 272 citations

Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution.

1990 • 247 citations

Structure at 2.5-.ANG. resolution of chemically synthesized Human Immunodeficiency Virus Type 1 protease complexed with a hydroxyethylene-based inhibitor

1991 • 231 citations

An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

1990 • 186 citations

Comparison of the HIV‐1 and HIV‐2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag‐Pol polyproteins

1991 • 161 citations

X-ray crystal structure of the HIV protease complex with L-700,417, an inhibitor with pseudo C2 symmetry

1991 • 118 citations

Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2.

1990 • 100 citations

Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling

1992 • 68 citations

The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations

1992 • 49 citations

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

1991 • 48 citations

Conformationally constrained renin inhibitory peptides: cyclic (3-1)-1-(carboxymethyl)-L-prolyl-L-phenylalanyl-L-histidinamide as a conformational restriction at the P2-P4 tripeptide portion of the angiotensinogen template

1991 • 25 citations