Stem-cell ecology and stem cells in motion

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

Osteoblastic cells regulate the haematopoietic stem cell niche

2003 • 3,370 citations

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2005 • 3,066 citations

SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

2005 • 3,056 citations

Identification of the haematopoietic stem cell niche and control of the niche size

2003 • 2,900 citations

The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

1978 • 2,290 citations

Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches

2006 • 2,228 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

2004 • 1,929 citations

Bone-marrow haematopoietic-stem-cell niches

2006 • 1,332 citations

Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

2006 • 1,297 citations

Immune cell migration in inflammation: present and future therapeutic targets

2005 • 1,262 citations

Targeting of CD44 eradicates human acute myeloid leukemic stem cells

2006 • 1,177 citations

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

2005 • 1,136 citations

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

2006 • 959 citations

Physiological Migration of Hematopoietic Stem and Progenitor Cells

2001 • 938 citations

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

2005 • 860 citations

Current understanding of stem cell mobilization

2002 • 801 citations

Hematopoiesis is severely altered in mice with an induced osteoblast deficiency

2004 • 787 citations

Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells

2005 • 764 citations

Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide

2003 • 758 citations

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

2005 • 750 citations

Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist

2003 • 728 citations

The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment

1999 • 691 citations

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

2005 • 675 citations

decapentaplegic Is Essential for the Maintenance and Division of Germline Stem Cells in the Drosophila Ovary

1998 • 648 citations

Cancer stem cells: lessons from leukemia

2005 • 610 citations

Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts [see comments]

1995 • 557 citations

Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

2003 • 544 citations

The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization

2005 • 510 citations

A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency

2007 • 507 citations

G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

2005 • 490 citations

Evidence for Stem Cells in the Peripheral Blood of Mice

1962 • 475 citations

Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin.

1993 • 455 citations

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

2007 • 428 citations

A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans

2002 • 427 citations

Rapid Mobilization of CD34+ Cells Following Administration of the CXCR4 Antagonist AMD3100 to Patients With Multiple Myeloma and Non-Hodgkin's Lymphoma

2004 • 420 citations

Increase in circulating stem cells following chemotherapy in man

1976 • 417 citations

Requirement for CD44 in homing and engraftment of BCR-ABL–expressing leukemic stem cells

2006 • 407 citations

Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

2007 • 406 citations

Somatic support cells restrict germline stem cell self-renewal and promote differentiation

2000 • 381 citations

The relative spatial distributions of CFUs and CFUc in the normal mouse femur

1975 • 371 citations

CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice

2004 • 344 citations

Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures

1996 • 329 citations

Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation

2005 • 318 citations

Deletion of α4 Integrins from Adult Hematopoietic Cells Reveals Roles in Homeostasis, Regeneration, and Homing

2003 • 303 citations

Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells

2005 • 288 citations

Therapeutic targeting of a stem cell niche

2007 • 285 citations

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

2005 • 279 citations

Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure

2003 • 257 citations

Cytokines and hematopoietic stem cell mobilization

2006 • 253 citations

Characterization of hematopoietic progenitor mobilization in protease-deficient mice

2004 • 241 citations

A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution

1999 • 233 citations

Expression of the integrin $alpha;4$beta;1 on melanoma cells can inhibit the invasive stage of metastasis formation

1994 • 221 citations

Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilization

2003 • 217 citations

Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells.

2002 • 212 citations

High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia

2001 • 198 citations

Successful autologous transplantation with peripheral blood hemopoietic cells in a patient with acute leukemia.

1986 • 194 citations

RELATION OF BLOOD CELLS TO CONNECTIVE TISSUES AND ENDOTHELIUM

1924 • 194 citations

Neutrophil-derived MMP-9 mediates synergistic mobilization of hematopoietic stem and progenitor cells by the combination of G-CSF and the chemokines GROβ/CXCL2 and GROβT /CXCL2Δ4

2003 • 191 citations

RARγ is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

2006 • 188 citations

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias

2006 • 188 citations

Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells

2002 • 185 citations

VEGFR-1 (FLT-1), β1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome

2007 • 184 citations

Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor

2002 • 165 citations

CXCR-4 Desensitization Is Associated with Tissue Localization of Hemopoietic Progenitor Cells

2001 • 165 citations

The Multiple Roles of Osteoclasts in Host Defense: Bone Remodeling and Hematopoietic Stem Cell Mobilization

2006 • 133 citations

Mobilization of early hematopoietic progenitor cells with BB-10010: a genetically engineered variant of human macrophage inflammatory protein- 1 alpha

1995 • 117 citations

Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4–/– chimeric mice

2005 • 110 citations

The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization

2003 • 110 citations

Increased tumor cell dissemination and cellular senescence in the absence of β1-integrin function

2007 • 103 citations

The Distribution of Haemopoietic Colony-Forming Units in the Mouse Femur, and its Modification by X Rays

1972 • 101 citations

VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease

2005 • 96 citations

Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms

1993 • 92 citations

Cyclophosphamide treatment expands the circulating hematopoietic stem cell pool in dogs.

1981 • 90 citations

MOBILIZATION OF HAEMOPOIETIC STEM CELLS (CFU) INTO THE PERIPHERAL BLOOD OF THE MOUSE; EFFECTS OF ENDOTOXIN AND OTHER COMPOUNDS

1972 • 87 citations

In Vivo Effects of Flt3/Flk2 Ligand on Mobilization of Hematopoietic Progenitors in Primates and Potent Synergistic Enhancement With Granulocyte Colony-Stimulating Factor

1997 • 87 citations

Peripheral blood stem cell mobilization

2002 • 86 citations

The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor

2005 • 84 citations

Mobilization of hematopoietic stem cells (CFU-C) into the peripheral blood of man by endotoxin.

1977 • 80 citations

Synergistic mobilization of hemopoietic progenitor cells using concurrent β1 and β2 integrin blockade or β2-deficient mice

2001 • 78 citations

CLL, but not normal, B cells are dependent on autocrine VEGF and α4β1 integrin for chemokine-induced motility on and through endothelium

2005 • 78 citations

Functional CXCR4-Expressing Microparticles and SDF-1 Correlate with Circulating Acute Myelogenous Leukemia Cells

2006 • 65 citations

The Role of Blood Stem Cells in Hematopoietic Cell Renewal

1998 • 64 citations

Release of colony-stimulating factor from monocytes by endotoxin and polyinosinic-polycytidylic acid.

1974 • 59 citations

Hematopoietic Growth Factors for Hematopoietic Stem Cell Mobilization and Expansion

2007 • 57 citations

Use of recombinant human growth hormone (rhGH) plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) for the mobilization and collection of CD34+ cells in poor mobilizers

2004 • 55 citations

Cyclophosphamide-induced alterations of bone marrow endothelium: implications in homing of marrow cells after transplantation.

1991 • 54 citations

Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+α4f/f mice are hematopoietic cell autonomous

2006 • 50 citations

HEMOPOIETIC STEM CELL PROLIFERATION AND MIGRATION FOLLOWING BORDETELLA PERTUSSIS VACCINE

1972 • 48 citations

Leukemia targeting ligands isolated from phage display peptide libraries

2007 • 37 citations

The relative spatial distributions of CFUs and CFUc in the normal mouse femur

1975 • 35 citations

Origin in repopulating cells after localized bone marrow depletion.

1968 • 34 citations

Increase in circulating stem cells following chemotherapy in man

1976 • 33 citations

Turnover of circulating hematopoietic stem cells.

1979 • 28 citations

Total body irradiation, etoposide, cyclophosphamide, and autologous peripheral blood stem-cell transplantation followed by randomization to therapy with interleukin-2 versus observation for patients with non-Hodgkin lymphoma: results of a phase 3 randomized trial by the Southwest Oncology Group (SWOG 9438)

2008 • 26 citations

The Role of Dextran Sulfate in Increasing the CFUc- Concentration in Dog Blood

1978 • 24 citations

Velocity sedimentation and cell cycle characteristics of granulopoietic progenitor cells (CFUc) in canine blood and bone marrow: influence of mobilization and CFUc depletion.

1980 • 23 citations

Stem Cell Migration Induced by Erythropoietin or Haemolytic Anaemia: the Effects of Actinomycin and Endotoxin Contamination of Erythropoietin Preparations

1979 • 21 citations

Origin of Repopulating Cells after Localized Bone Marrow Depletion

1969 • 20 citations

Quantitative aspects of granulocytic progenitor cell (CFUc) mobilization from extravascular sites in dogs using dextran sulphate (DS)

1982 • 12 citations

Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice

2008 • 12 citations

STUDIES ON THE MECHANISM OF HAEMOPOIETIC STEM CELL (CFUs) MOBILIZATION

1979 • 8 citations

Self-renewal capacity of mobilized murine haemopoietic stem cells.

1987 • 7 citations

Mechanism of Poly I: Poly C Stimulation of Human Bone Marrow Colony Growth In Vitro

1978 • 3 citations