Heme oxygenase—regulation of and physiological implication in heme catabolism

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

1968 • 1,767 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Antioxidant activity of albumin-bound bilirubin.

1987 • 763 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat.

1992 • 691 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Key features of heat shock regulatory elements.

1988 • 566 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

1987 • 466 citations

Germline Transformation Used to Define Key Features of Heat-Shock Response Elements

1988 • 451 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

1989 • 439 citations

Does carbon monoxide have a physiological function?

1991 • 425 citations

Transcriptional control of rat heme oxygenase by heat shock.

1987 • 415 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.

1970 • 396 citations

Induction of Haem Oxygenase as a Defence Against Oxidative Stress

1990 • 322 citations

Human heme oxygenase cDNA and induction of its mRNA by hemin

1988 • 320 citations

Evidence suggesting that the two forms of heme oxygenase are products of different genes.

1988 • 288 citations

Activation of Heat Shock Factor 2 during Hemin-Induced Differentiation of Human Erythroleukemia Cells

1992 • 281 citations

Multiple forms of the human gene-specific transcription factor USF. I. Complete purification and identification of USF from HeLa cell nuclei.

1988 • 276 citations

Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.

1991 • 267 citations

Reversal of long-term potentiation by inhibitors of haem oxygenase

1993 • 265 citations

Reduced nicotinamide adenine dinucleotide phosphate dependent biliverdin reductase. Partial purification and characterization

1970 • 264 citations

Activation of heat-shock genes in eukaryotes

1985 • 263 citations

Cobalt Induction of Hepatic Heme Oxygenase; with Evidence That Cytochrome P -450 Is Not Essential for This Enzyme Activity

1974 • 261 citations

Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform.

1986 • 260 citations

The physiological significance of heme oxygenase

1988 • 240 citations

Transcriptional Activation of the Heme Oxygenase Gene by Heme and Cadmium in Mouse Hepatoma Cells

1989 • 230 citations

Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.

1990 • 226 citations

Nucleotide sequence and organization of the rat heme oxygenase gene.

1987 • 210 citations

Functional Analysis of cDNAs for Two Types of Human Heme Oxygenase and Evidence for Their Separate Regulation1

1993 • 196 citations

Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene.

1992 • 194 citations

Human heme oxygenase-2: Characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal

1992 • 184 citations

The Adenovirus Major Late Transcription Factor Activates the Rat γ-Fibrinogen Promoter

1987 • 177 citations

Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats.

1990 • 170 citations

Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.

1992 • 168 citations

Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected.

1990 • 166 citations

The human 32‐kDa stress protein induced by exposure to arsenite and cadmium ions is heme oxygenase

1989 • 163 citations

Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

1990 • 147 citations

Structural organization of the human heme oxygenase gene and the function of its promoter

1989 • 143 citations

Inducible heme oxygenase in the kidney: a model for the homeostatic control of hemoglobin catabolism

1971 • 131 citations

The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells

1991 • 130 citations

THE ENZYMATIC DEGRADATION OF HEMOGLOBIN TO BILE PIGMENTS BY MACROPHAGES

1971 • 130 citations

Multiplicity of Heme Oxygenase Isozymes

1989 • 116 citations

Purification and properties of heme oxygenase from rat liver microsomes.

1979 • 112 citations

[Regulation of heme oxygenase gene expression].

1989 • 106 citations

Function and induction of the microsomal heme oxygenase

1983 • 98 citations

Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response.

1989 • 97 citations

Erythrocyte Catabolism by Macrophages In Vitro THE EFFECT OF HYDROCORTISONE ON ERYTHROPHAGOCYTOSIS AND ON THE INDUCTION OF HEME OXYGENASE

1973 • 90 citations

Induction of heme oxygenase by hemin in cultured pig alveolar macrophages

1978 • 90 citations

Heme oxygenase induction by CoCl2, Co-protoporphyrin IX, phenylhydrazine, and diamide: Evidence for oxidative stress involvement

1991 • 87 citations

Separate Regulation of Heme Oxygenase and Heat Shock Protein 70 mRNA Expression in the Rat Heart by Hemodynamic Stress

1993 • 80 citations

Heme oxygenase is a positive acute-phase reactant in human Hep3B hepatoma cells

1992 • 80 citations

Heme catabolism by heme oxygenase: physiology, regulation, and mechanism of action.

1988 • 77 citations

Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: Possible heme-binding site?

1991 • 74 citations

Reduction of biliverdin and placental transfer of bilirubin and biliverdin in the pregnant guinea pig

1981 • 73 citations

Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells.

1988 • 72 citations

Differential regulation of heme oxygenase isozymes by Sn- and Zn-protoporphyrins: Possible relevance to suppression of hyperbilirubinemia

1992 • 69 citations

Interaction of upstream stimulatory factor with the human heme oxygenase gene promoter

1990 • 62 citations

Mechanism of increase of heme oxygenase activity induced by hemin in cultured pig alveolar macrophages

1979 • 61 citations

Stimulation of heme oxygenase in macrophages and liver by endotoxin.

1974 • 60 citations

Identification of a cis-regulatory element and putative trans-acting factors responsible for 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of heme oxygenase expression in myelomonocytic cell lines.

1993 • 57 citations

Heat shock induction of heme oxygenase mRNA in human Hep 3B hepatoma cells

1989 • 54 citations

Ultraviolet A (320–380 nm) radiation causes an alteration in the binding of a specific protein/protein complex to a short region of the promoter of the human heme oxygenase 1 gene

1993 • 50 citations

Induction of heme oxygenase in rat liver. Increase of the specific mRNA by treatment with various chemicals and immunological identity of the enzymes in various tissues as well as the induced enzymes.

1983 • 49 citations

Identification of a nuclear protein that constitutively recognizes the sequence containing a heat‐shock element

1993 • 49 citations

Induction in Mouse Peritoneal Macrophages of 34 kDa Stress Protein and Heme Oxygenase by Sulfhydryl-Reactive Agents1

1990 • 49 citations

Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells

1990 • 46 citations

Domains of Rat Heme Oxygenase-2: The Amino Terminus and Histidine 151 Are Required for Heme Oxidation

1993 • 45 citations

Importance of histidine residue 25 of rat heme oxygenase for its catalytic activity

1992 • 45 citations

Transcriptional control of the rat heme oxygenase gene by a nuclear protein that interacts with adenovirus 2 major late promoter

1989 • 42 citations

Expression of heme oxygenase gene in rat and human liver

1988 • 39 citations

Heme stimulation of cellular growth and differentiation.

1988 • 39 citations

Cloning, sequencing and expression of cDNA for chick liver haem oxygenase. Comparison of avian and mammalian cDNAs and deduced proteins

1991 • 39 citations

Effects of hypoxic and CO hypoxia on isolated hearts

1975 • 32 citations

A heat-inducible nuclear factor that binds to the heat-shock element of the human haem oxygenase gene

1991 • 28 citations

Elevated levels of heme oxygenase‐1 activity and mRNA in peripheral blood adherent cells of acquired immunodeficiency syndrome patients

1993 • 27 citations

Transcriptional activation of the heme oxygenase gene by TPA in mouse M1 cells during their differentiation to macrophage

1990 • 25 citations

Heme oxygenase-2 mRNA: Developmental expression in the rat liver and response to cobalt chloride

1990 • 18 citations

The formation of biliverdin by chicken macrophages in tissue culture observations on the effect of inhibitors

1970 • 15 citations

Hepatic heme and drug metabolism in rats with chronic mountain sickness

1986 • 14 citations

Induction of heme oxygenase in rat liver

1983 • 13 citations

Nucleotide sequence of cDNA for porcine heme oxygenase and its expression in Escherichia coli.

1992 • 11 citations

Intracellular Site of Synthesis of Microsomal Heme Oxygenase in Pig Spleen<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1980 • 8 citations