Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Statistical Method in Biological Assay.

1979 • 3,679 citations

Handbook of Psychopharmacology

1988 • 2,778 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1989 • 1,283 citations

Type I and Type II GABA _A -Benzodiazepine Receptors Produced in Transfected Cells

1989 • 716 citations

Interaction of Convulsive Ligands with Benzodiazepine Receptors

1982 • 549 citations

Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors

1979 • 408 citations

Molecular heterogeneity of benzodiazepine receptors

1980 • 329 citations

New anticonvulsant drugs

1987 • 314 citations

A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, ?-carbolines, and phenobarbitone

1982 • 312 citations

[³H]Propyl ?-Carboline-3-Carboxylate as a Selective Radioligand for the BZ₁Benzodiazepine Receptor Subclass

1981 • 255 citations

Benzodiazepine receptors

1984 • 253 citations

A novel α subunit in rat brain GABAA receptors

1989 • 251 citations

Benzodiazepine receptor ligands with positive and negative efficacy

1983 • 244 citations

Understanding the GABAA receptor: a chemically gated ion channel

1988 • 217 citations

A Review of Mouse Mutants as Genetic Models of Epilepsy

1985 • 174 citations

Separate subunits for agonist and benzodiazepine binding in the gamma-aminobutyric acidA receptor oligomer.

1986 • 168 citations

Anxiogenic and non-anxiogenic benzodiazepine antagonists

1983 • 165 citations

Audiogenic seizures in DBA/2 mice discriminate sensitively between low efficacy benzodazepine receptor agonists and inverse agonists

1983 • 147 citations

An allosteric model for benzodiazepine receptor function

1983 • 102 citations

Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures.

1984 • 95 citations

The neuropharmacology of various diazepam antagonists

1983 • 86 citations

On a brain polypeptide functioning as a putative effector for the recognition sites of benzodiazepine and beta-carboline derivatives

1983 • 84 citations

1,3-Dihydro-2H-1,4-benzodiazepine-2-ones and Their 4-Oxides

1962 • 78 citations

Differential pharmacological effects of β-carboline-3-carboxylic acid esters

1982 • 77 citations

Anticonvulsant Action of a 1,5‐Benzodiazepine, Clobazam, in Reflex Epilepsy

1978 • 66 citations

Low-dose benzodiazepine neuronal inhibition: enhanced Ca2+-mediated K+-conductance

1983 • 61 citations

Molecular structure of Ro15-1788 and a model for the binding of benzodiazepine receptor ligands. Structural identification of common features in antagonists.

1985 • 61 citations

Theoretical structure-activity studies of benzodiazepine analogues. Requirements for receptor affinity and activity.

1984 • 57 citations

Anticonvulsant actions of DS 103–282 Pharmacological studies in rodents and the baboon, Papio papio

1984 • 51 citations

Diazepam-stimulated increases in the synaptosomal uptake of 45ca2+: Reversal by dihydropyridine calcium channel antagonists

1984 • 47 citations

Regional heterogeneity of benzodiazepine receptors at 37°C: An study in various regions of the rat brain

1982 • 46 citations

Comparison of benzodiazepine receptor binding in membranes from human or rat brain

1985 • 41 citations

Theoretical structure-activity studies of beta-carboline analogs. Requirements for benzodiazepine receptor affinity and antagonist activity.

1985 • 39 citations

Bidirectional effects of β-carbolines in reflex epilepsy

1987 • 38 citations

Interactions of β-carbolines with the benzodiazepine receptor: Structure-activity relationships

1981 • 36 citations

Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones

1989 • 35 citations

Species differences in clobazam metabolism and antileptazol effect

1980 • 21 citations

Synthesis of .beta.-carboline-benzodiazepine hybrid molecules: use of the known structural requirements for benzodiazepine and .beta.-carboline binding in designing a novel, high-affinity ligand for the benzodiazepine receptor

1987 • 20 citations

Anticonvulsant action of clobazam and desmethylclobazam in reflex epilepsy in rodents and baboons

1982 • 18 citations

Anticonvulsant activity in photosensitive baboons, Papio papio, of two new 1,5 benzodiazepines

1979 • 17 citations

Benzodiazepine receptor heterogeneity: possible molecular basis and functional significance.

1984 • 16 citations

Computer-assisted determination of benzodiazepine receptor heterogeneity

1984 • 14 citations

Anticonvulsant effect of denzimolin DBA/2 mice

1987 • 11 citations