Characterization and Cloning of a 58/53-kDa Substrate of the Insulin Receptor Tyrosine Kinase

Basic local alignment search tool

1990 • 87,358 citations

Protein modules and signalling networks

1995 • 2,447 citations

The insulin signaling system.

1994 • 1,733 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

The insulin receptor: structure, function, and signaling

1994 • 434 citations

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1994 • 302 citations

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.

1994 • 286 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Import of proteins into peroxisomes and other microbodies

1992 • 210 citations

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

1995 • 201 citations

SH3 Domains: Minding your p's and q's

1995 • 197 citations

Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment.

1995 • 184 citations

Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.

1994 • 145 citations

Interleukin-13 Signal Transduction in Lymphohemopoietic Cells

1995 • 145 citations

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

1994 • 126 citations

The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.

1993 • 120 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Characterization of a 60-kilodalton substrate of the insulin receptor kinase

1994 • 80 citations

Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C.

1994 • 78 citations

Activation of Protein Kinase Cα Inhibits Signaling by Members of the Insulin Receptor Family

1995 • 74 citations

c phosphorylation and activation of the IGF-I receptor in src-transformed cells.

1994 • 72 citations

Identification of SHC as a Substrate of the Insulin Receptor Kinase Distinct from the GAP-Associated 62-kDa Tyrosine Phosphoprotein

1993 • 56 citations

Identification of the Major SHPTP2-binding Protein That Is Tyrosine-phosphorylated in Response to Insulin

1995 • 48 citations

Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.

1994 • 37 citations

Phosphatidylinositol-3-kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex

1992 • 28 citations

Quantitative analysis of SH2 domain binding. Evidence for specificity and competition.

1992 • 21 citations

[9] Isolation of tyrosine-phosphorylated proteins and generation of monoclonal antibodies

1991 • 13 citations

Differential expression of novel genes by bone marrow-derived macrophage populations

1995 • 9 citations