Studies on identifying the folylpolyglutamate binding sites of Lactobacillus casei thymidylate synthetase

Direct Spectrophotometric Evidence for the Oxidation of Tetrahydrofolate during the Enzymatic Synthesis of Thymidylate

1961 • 209 citations

Solid-phase synthesis of polyglutamates of folic acid

1969 • 185 citations

The Purification and Properties of Thymidylate Synthetase from Chick Embryo Extracts

1967 • 119 citations

Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis

1976 • 112 citations

Human thymidylate synthetase derived from blast cells of patients with acture myelocytic leukemia. Purification and chracterization.

1977 • 79 citations

The primary structure of Lactobacillus casei thymidylate synthetase. III. The use of 2-(2-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine and limited tryptic peptides to establish the complete amino acid sequence of the enzyme.

1979 • 55 citations

Effect of substrate analogs on the circular dichroic spectra of thymidylate synthetase from Lactobacillus casei

1975 • 54 citations

High molecular weight derivatives of methotrexate as chemotherapeutic agents.

1977 • 52 citations

The primary structure of Lactobacillus casei thymidylate synthetase. I. The isolation of cyanogen bromide peptides 1 through 5 and the complete amino acid sequence of CNBr 1, 2, 3, and 5.

1979 • 46 citations

Developments in Biochemistry

1947 • 43 citations

The primary structure of Lactobacillus casei thymidylate synthetase. II. The complete amino acid sequence of the active site peptide, CNBr 4.

1979 • 41 citations

Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacilluscasei thymidylate synthetase

1976 • 39 citations

Polyglutamyl derivatives of tetrahydrofolate as substrates for Lactobacillus casei thymidylate synthase

1981 • 37 citations

Differential inhibition of host and viral thymidylate synthetases by folylpolyglutamates.

1979 • 31 citations

Protective effect of the pteroylpolyglutamates and phosphate on the proteolytic inactivation of thymidylate synthetase

1977 • 29 citations

Thymidylate synthetase from Diplococcus pneumoniae properties and inhibition by folate analogs

1975 • 27 citations

Quinazoline analogues of folic acid as inhibitors of thymidylate synthetase from bacterial and mammalian sources.

1979 • 23 citations

Relative affinity of 5, 10-methylenetetrahydrofolylpolyglutamates for the Lactobacillus casei thymidylate synthetase-5-fluorodeoxyuridylate binary complex

1981 • 20 citations