Targeted therapy for cancer using PARP inhibitors

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

2005 • 4,715 citations

Hallmarks of 'BRCAness' in sporadic cancers

2004 • 1,586 citations

The PARP superfamily

2004 • 1,377 citations

The Concept of Synthetic Lethality in the Context of Anticancer Therapy

2005 • 1,324 citations

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

2006 • 1,252 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

2008 • 1,015 citations

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

2001 • 980 citations

BRCA1 and BRCA2: 1994 and beyond

2004 • 941 citations

Resistance to therapy caused by intragenic deletion in BRCA2

2008 • 938 citations

Triple negative tumours: a critical review

2007 • 870 citations

Integrating Genetic Approaches into the Discovery of Anticancer Drugs

1997 • 757 citations

ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

2007 • 745 citations

Breast and Ovarian Cancer

2003 • 605 citations

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

2006 • 597 citations

Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361

2004 • 476 citations

BRCA1 regulates human mammary stem/progenitor cell fate

2008 • 448 citations

Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian Carcinomas with Platinum Resistance

2008 • 440 citations

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences

2001 • 420 citations

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

2008 • 318 citations

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination

2003 • 291 citations

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

2005 • 257 citations

Utilizing RNA interference to enhance cancer drug discovery

2007 • 246 citations

Exploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for Cancer

2005 • 188 citations

Poly(ADP-ribose) Polymerase (PARP-1) in Homologous Recombination and as a Target for Cancer Therapy

2005 • 176 citations

Poly(ADP‐ribose) Polymerase–1 Activation During DNA Damage and Repair

2006 • 161 citations

Toward specific functions of poly(ADP-ribose) polymerase-2

2008 • 154 citations

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency

2005 • 149 citations

PARP Inhibitor Development for Systemic Cancer Targeting

2007 • 140 citations

The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives

2006 • 119 citations

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

2004 • 118 citations

Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage

1999 • 110 citations

Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.

2001 • 91 citations

Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase

2005 • 90 citations

Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice

2006 • 78 citations

First in human phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of KU-0059436 (Ku), a small molecule inhibitor of poly ADP-ribose polymerase (PARP) in cancer patients (p), including BRCA1/2 mutation carriers

2007 • 76 citations

Efficient Deletion of Normal Brca2-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy

2005 • 59 citations

Targeting Poly(ADP-Ribose) Polymerase: A Two-Armed Strategy for Cancer Therapy

2007 • 56 citations

Strand breaks arising from the repair of the 5-bromodeoxyuridine-substituted template and methyl methanesulphonate-induced lesions can explain the formation of sister chromatid exchanges

1985 • 54 citations

A regulatory network of canonical nuclear factor-κB activation predicts high-grade glioma outcome

2007 • 9 citations

Binding mode of novel 1-substituted quinazoline derivatives to poly(ADP-ribose) polymerase-catalytic domain, revealed by X-ray crystal structure analysis of complexes

2006 • 7 citations