Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

2002 • 1,352 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

1998 • 900 citations

Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

1996 • 775 citations

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

1999 • 713 citations

Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1

2002 • 674 citations

XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

1996 • 607 citations

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

2003 • 606 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins

2000 • 532 citations

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1999 • 518 citations

Base Excision Repair Is Impaired in Mammalian Cells Lacking Poly(ADP-ribose) Polymerase-1

2000 • 487 citations

The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

1999 • 386 citations

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

1998 • 350 citations

Physiology and pathophysiology of poly(ADP‐ribosyl)ation *

2001 • 333 citations

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

2003 • 331 citations

[36] SSAP: Sequential structure alignment program for protein structure comparison

1996 • 330 citations

Spatial and Temporal Cellular Responses to Single-Strand Breaks in Human Cells

2003 • 302 citations

Spatial and Temporal Cellular Responses to Single-Strand Breaks in Human Cells

2003 • 291 citations

Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase

2000 • 281 citations

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

1996 • 234 citations

TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression

2001 • 215 citations

Crystal Structure of Diphtheria Toxin Bound to Nicotinamide Adenine Dinucleotide

1996 • 200 citations

Inhibitor and NAD⁺ Binding to Poly(ADP-ribose) Polymerase As Derived from Crystal Structures and Homology Modeling^,

1998 • 196 citations

The mechanism of the elongation and branching reaction of Poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis

1998 • 160 citations

PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression

2003 • 157 citations

A Human Poly(ADP-ribose) Polymerase Gene Family (ADPRTL): cDNA Cloning of Two Novel Poly(ADP-ribose) Polymerase Homologues

1999 • 145 citations

TCDD-Inducible Poly(ADP-ribose) Polymerase: A Novel Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

2001 • 141 citations

Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation).

1985 • 126 citations

Identification of a Novel Human Tankyrase through Its Interaction with the Adaptor Protein Grb14

2001 • 118 citations

Inhibition of DNA polymerase α, DNA polymerase β, terminal deoxynucleotidyl transferase, and DNA ligase II by poly(ADP-ribosyl)ation reaction in vitro

1985 • 111 citations

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy

1995 • 92 citations

Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.

2001 • 91 citations

Functional interactions of p53 with poly(ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: covalent poly(ADP-ribosyl)ation of p53 by exogenous PARP and noncovalent binding of p53 to the M(r) 85,000 proteolytic fragment.

1998 • 89 citations

DNA Excision Repair and DNA Damage-Induced Apoptosis Are Linked to Poly(ADP-Ribosyl)ation but Have Different Requirements for p53

2000 • 71 citations

Crystal Structure of Diphtheria Toxin Bound to Nicotinamide Adenine Dinucleotide

1997 • 68 citations

pADPRT‐2: a novel mammalian polymerizing(ADP‐ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans¹

1999 • 53 citations

Poly(ADP-ribosylation) of histones in intact human keratinocytes

1989 • 53 citations

From DNA Damage and Stress Signalling to Cell Death

2001 • 19 citations