On the role of magnesium ions in RNA stability

Dominant forces in protein folding

1990 • 3,682 citations

The physical chemistry of electrolytic solutions

1950 • 3,057 citations

Limiting Laws and Counterion Condensation in Polyelectrolyte Solutions I. Colligative Properties

1969 • 2,920 citations

Theoretical aspects of DNA-protein interactions: Co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice

1974 • 2,905 citations

The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides

1978 • 2,873 citations

Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity

1978 • 1,651 citations

Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing

1996 • 1,240 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

Chemistry of the metal chelate compounds

1953 • 1,006 citations

Three-dimensional structure of a hammerhead ribozyme

1994 • 944 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

The Physical Chemistry of Electrolytic Solutions.

1958 • 879 citations

Cation Selective Glass Electrodes and their Mode of Operation

1962 • 844 citations

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

1995 • 675 citations

Counterion binding in polyelectrolyte theory

1979 • 615 citations

Metal ions in solution

1979 • 609 citations

Reevaluation of the Born model of ion hydration

1985 • 569 citations

Calculating total electrostatic energies with the nonlinear Poisson-Boltzmann equation

1990 • 549 citations

Ionic selectivity revisited: The role of kinetic and equilibrium processes in ion permeation through channels

1983 • 535 citations

Macroscopic models of aqueous solutions: biological and chemical applications

1993 • 520 citations

Ionic hydration in chemistry and biophysics

1982 • 515 citations

Ribozymes: A Distinct Class of Metalloenzymes

1993 • 440 citations

The Physical and Chemical Properties of Nucleic Acids

1967 • 416 citations

Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme

1996 • 407 citations

The B-DNA Dodecamer at High Resolution Reveals a Spine of Water on Sodium^,

1998 • 399 citations

Modern Electrochemistry

1970 • 394 citations

Metals, Motifs, and Recognition in the Crystal Structure of a 5S rRNA Domain

1997 • 392 citations

Structural analysis of spermine and magnesium ion binding to yeast phenylalanine transfer RNA.

1978 • 377 citations

The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

1998 • 373 citations

Role of divalent metal ions in the hammerhead RNA cleavage reaction

1991 • 365 citations

Macromolecular binding

1975 • 364 citations

Polye1ectrolytes

1971 • 354 citations

Visualizing the Higher Order Folding of a Catalytic RNA Molecule

1991 • 354 citations

Raman spectroscopy of DNA-metal complexes. I. Interactions and conformational effects of the divalent cations: Mg, Ca, Sr, Ba, Mn, Co, Ni, Cu, Pd, and Cd

1993 • 353 citations

Computational Methods to Predict Binding Free Energy in Ligand-Receptor Complexes

1995 • 345 citations

A crystallographic study of metal-binding to yeast phenylalanine transfer RNA

1977 • 322 citations

Kinetic Intermediates in RNA Folding

1994 • 306 citations

A magnesium ion core at the heart of a ribozyme domain

1997 • 294 citations

Salt-Nucleic Acid Interactions

1995 • 288 citations

The electrostatic potential of B‐DNA

1989 • 263 citations

A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction

1994 • 261 citations

Further refinement of the structure of yeast tRNAPhe

1978 • 243 citations

Polyelectrolyte Theories and their Applications to DNA

1982 • 234 citations

Heats of the helix–coil transitions of the poly A–poly U complexes

1968 • 230 citations

Conformational changes of transfer ribonucleic acid. Equilibrium phase diagrams

1972 • 228 citations

Metal-binding sites in the major groove of a large ribozyme domain

1996 • 219 citations

An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme

1993 • 214 citations

RNA folding causes secondary structure rearrangement

1998 • 214 citations

A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor

1998 • 210 citations

Renaturation of transfer ribonucleic acids through site binding of magnesium.

1966 • 200 citations

ION DISTRIBUTIONS AROUND DNA AND OTHER CYLINDRICAL POLYIONS: Theoretical Descriptions and Physical Implications

1990 • 183 citations

Conformational changes of transfer RNA. The role of magnesium(II)

1976 • 182 citations

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and magnesium binding

1991 • 182 citations

Tertiary Structure in Transfer Ribonucleic Acids

1966 • 175 citations

Salt Effects on Ligand-DNA Binding

1994 • 173 citations

Chain Model for Polyelectrolytes. VII. Potentiometric Titration and Ion Binding in Solutions of Linear Polyelectrolytes

1962 • 160 citations

tRNA Conformation and Magnesium Binding. A Study of Yeast Phenylalanine-Specific tRNA by a Fluorescent Indicator and Differential Melting Curves

1975 • 159 citations

Biological macromolecules and polyelectrolytes in solution

1977 • 159 citations

Stabilization of RNA Structure by Mg Ions

1994 • 151 citations

Ionic distributions near polyelectrolytes. A comparison of theoretical approaches

1985 • 148 citations

Solution structure of a metal-binding site in the major groove of RNA complexed with cobalt (III) hexammine

1997 • 143 citations

Ionic interactions and the global conformations of the hammerhead ribozyme

1995 • 141 citations

Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme

1989 • 139 citations

RNA pseudoknots

1990 • 136 citations

Transfer RNA in Solution: Selected Topics

1980 • 130 citations

Raman spectroscopic study of the effects of Ca²⁺, Mg²⁺, Zn²⁺, and Cd²⁺ ions on calf thymus DNA: Binding sites and conformational changes

1990 • 127 citations

Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis

1991 • 123 citations

Restrained refinement of the monoclinic form of yeast phenylalanine transfer RNA. Temperature factors and dynamics, coordinated waters, and base-pair propeller twist angles

1986 • 120 citations

Salt effects on polyelectrolyte–ligand binding: Comparison of Poisson–Boltzmann, and limiting law/counterion binding models

1995 • 119 citations

Interaction of metallic cations with DNA VI. Specific binding of Mg⁺⁺ and Mn⁺⁺

1973 • 117 citations

Proton magnetic relaxation studies of manganous complexes of transfer RNA and related compounds

1969 • 115 citations

Interaction of Nucleic Acids

2021 • 114 citations

Polyelectrolyte electrostatics: Salt dependence, entropic, and enthalpic contributions to free energy in the nonlinear Poisson–Boltzmann model

1995 • 112 citations

Thermodynamic analysis of transfer RNA unfolding

1978 • 111 citations

The binding of Mg⁺⁺ ions to polyadenylate, polyuridylate, and their complexes

1971 • 110 citations

The kinetic folding pathway of the Tetrahymena ribozyme reveals possible similarities between RNA and protein folding

1996 • 109 citations

Interactions of polyelectrolytes with simple electrolytes. II. Donnan equilibria obtained with DNA in solutions of 1-1 electrolytes

1967 • 108 citations

Mg²⁺-Dependent Conformational Changes in the Hammerhead Ribozyme

1996 • 108 citations

Equilibrium binding of magnesium(II) by Escherichia coli tRNA^fMet

1976 • 106 citations

Magnesium Ions Are Required by Bacillus subtilis Ribonuclease P RNA for both Binding and Cleaving Precursor tRNA^Asp

1996 • 103 citations

Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA

1974 • 102 citations

Nuclear magnetic resonance studies of the hammerhead ribozyme domain

1991 • 96 citations

Cooperative Binding of Manganese (II) to Transfer RNA

1970 • 96 citations

Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe

1974 • 95 citations

The interaction of polynucleotides with cations

1959 • 95 citations

Two major tertiary folding transitions of the Tetrahymena catalytic RNA.

1994 • 94 citations

Structure of the titanium-iron cyanide complexes

1968 • 94 citations

Thermodynamic studies of transfer ribonucleic acids. I. Magnesium binding to yeast phenylalanine transfer ribonucleic acid

1972 • 89 citations

Affinities and selectivities of divalent cation binding sites within an RNA tertiary structure

1997 • 89 citations

Colligative properties of polyelectrolyte solutions in excess of salt

1963 • 86 citations

Effects of Mg2+, K+, and H+ on an equilibrium between alternative conformations of an RNA pseudoknot

1997 • 85 citations

tRNA structure and binding sites for cations

1972 • 77 citations

Electron Paramagnetic Resonance Spectroscopic Measurement of Mn²⁺ Binding Affinities to the Hammerhead Ribozyme and Correlation with Cleavage Activity

1998 • 76 citations

Salt dependence of oligoion-polyion binding: a thermodynamic description based on preferential interaction coefficients

1993 • 74 citations

Mechanism of electrophilic reactions of carbon-metal bonded platinum(II) complexes. Comparison between transition and post-transition organometallic compounds

1967 • 69 citations

The internal equilibrium of the hammerhead ribozyme reaction

1995 • 69 citations

Bases Defining an Ammonium and Magnesium Ion-Dependent Tertiary Structure Within the Large Subunit Ribosomal RNA

1994 • 65 citations

Thermodynamic and kinetic parameters of ion condensation to polynucleotides

1976 • 63 citations

Hydration Effects Accompanying the Substitution of Counterions in the Ionic Atmosphere of Poly(rA)·Poly(rU) and Poly(rA)·2Poly(rU) Helices

1996 • 62 citations

Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks.

1996 • 62 citations

The Electrostatic Contribution to the B to Z Transition of DNA

1996 • 61 citations

Application of Polyelectrolyte Theories for Analysis of DNA Melting in the Presence of Na+ and Mg2+ Ions

1998 • 59 citations

Monovalent and Divalent Salt Effects on Electrostatic Free Energies Defined by the Nonlinear Poisson−Boltzmann Equation: Application to DNA Binding Reactions

1997 • 59 citations

²⁵ Mg NMR in DNA solutions: Dominance of site binding effects

1980 • 59 citations

Demonstration and origin of six tertiary base pair resonances in the NMR spectrum of E. coli tRNAVal1

1975 • 56 citations

Allosteric interpretation of Mg²⁺ ion binding to the denaturable Escherichia coli tRNA^Glu2

1976 • 54 citations

Electrical potential of transfer RNAs: codon-anticodon recognition

1990 • 53 citations

Magnesium ion inner sphere complex in the anticodon loop of tRNAPhe

1982 • 51 citations

Folding of an mRNA Pseudoknot Required for Stop Codon Readthrough: Effects of Mono- and Divalent Ions on Stability

1997 • 51 citations

Effects of Divalent Metal Ions on Individual Steps of the Tetrahymena Ribozyme Reaction

1997 • 50 citations

Specific ammonium ion requirement for functional ribosomal RNA tertiary structure

1993 • 50 citations

A Simple Interpretation of Donnan Equilibria Obtained with Long Chain Polyphosphates¹

1958 • 48 citations

Electrostatic effects in divalent ion binding to tRNA

1977 • 46 citations

Characterization of the secondary structure and melting of a self-cleaved RNA hammerhead domain by proton NMR spectroscopy

1990 • 46 citations

Interactions of polyelectrolytes with simple electrolytes. III. The binding of magnesium ion by deoxyribonucleic acid

1968 • 45 citations

The mode of Mg⁺⁺binding to oligonucleotides. Inner sphere complexes as markers for recognition?

1979 • 44 citations

On the coordination properties of Eu3+ bound to tRNA

1985 • 43 citations

Ionic distributions and competitive association in DNA/mixed salt solutions

1988 • 42 citations

Anticodon loop of tRNAPhe: structure, dynamics, and magnesium binding

1986 • 41 citations

Europium as a fluorescent probe of metal binding sites on transfer ribonucleic acid. I. Binding to Escherichia coli formylmethionine transfer ribonucleic acid

1974 • 41 citations

Equilibrium Unfolding (Folding) Pathway of a Model H-type Pseudoknotted RNA: The Role of Magnesium Ions in Stability

1998 • 38 citations

Biostructural chemistry of magnesium ion: characterization of the weak binding sites on tRNAPhe(yeast). Implications for conformational change and activity

1990 • 37 citations

Role of Divalent Ions in Folding of tRNA

1977 • 37 citations

Thermodynamics of Folding of the RNA Pseudoknot of the T4 Gene 32 Autoregulatory Messenger RNA

1996 • 36 citations

The Interaction of Na Ions with Synthetic Polynucleotides

1972 • 33 citations

Significance and mechanism of divalent-ion binding to transfer RNA

1982 • 31 citations

Effect of cations on tRNA structure

1977 • 31 citations

Polyelectrolyte Solutions: A Theoretical Introduction

1963 • 30 citations

Polyelectrolyte solutions: A theoretical introduction

1962 • 30 citations

Theory of Protein Solutions. I

1955 • 29 citations

Coordination chemistry of magnesium ions and 5S rRNA (Escherichia coli): binding parameters, ligand symmetry, and implications for activity

1991 • 28 citations

Interaction of magnesium ions with poly A and poly U

1971 • 28 citations

On the binding of Mg2+ and Mn2+ to tRNA

1977 • 27 citations

Divalent metal ions and the internal equilibrium of the hammerhead ribozyme

1995 • 23 citations

Sequence selective coordination of Mg2+(aq) to DNA

1993 • 23 citations

Ultrasonic study of the kinetics of counterion site binding in aqueous solutions of polyelectrolytes

1974 • 21 citations

Metal Ion Dependence of Active-Site Structure of the Tetrahymena Ribozyme Revealed by Site-Specific Photo-crosslinking

1994 • 19 citations

Metallobiochemistry of a ribosomal RNA. A possible role for Na+ and K+ in the regulation of Mg2+ binding sites on Escherichia coli 5S rRNA: implications for activity

1991 • 9 citations

Bound states in electrolyte solutions: Theory of ion association

1996 • 6 citations

Gametogenesis: Keeping the male element under control

1998 • 3 citations