The role of ligand in estrogen receptor regulation of gene expression

Gene regulation by steroid hormones

1989 • 3,466 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells

1984 • 1,416 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Nuclear localization of unoccupied oestrogen receptors

1984 • 882 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

1990 • 756 citations

Current Models of Steroid Hormone Action: A Critique

1976 • 707 citations

Hormone Receptors: Studies on the Interaction of Estrogen with the Uterus

1968 • 537 citations

Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer

1989 • 508 citations

Oestrogen and glucocorticoid responsive elements are closely related but distinct

1987 • 353 citations

Transcriptional regulation by dimerization: Two sides to an incestuous relationship

1990 • 343 citations

Commitment and activation at pol II promoters: A tail of protein-protein interactions

1990 • 332 citations

Activation, Transformation, and Subunit Structure of Steroid Hormone Receptors

1982 • 323 citations

Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes

1984 • 261 citations

Identification of an estrogen-responsive element from the 5'-flanking region of the rat prolactin gene.

1987 • 231 citations

Specific binding of estrogen receptor to the estrogen response element.

1989 • 199 citations

Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90

1990 • 187 citations

Equilibrium: the intracellular distribution of steroid receptors

1979 • 176 citations

Nuclear Localization of Unoccupied Receptors for Glucocorticoids, Estrogens, and Progesterone in GH³Cells*

1985 • 172 citations

Equilibrium binding of estradiol by uterine cell suspensions and whole uteri in vitro

1974 • 169 citations

Novel Antipeptide Antibodies to the Human Glucocorticoid Receptor: Recognition of Multiple Receptor Formsin Vitroand Distinct Localization of Cytoplasmic and Nuclear Receptors

1990 • 140 citations

Immunocytochemical Localization of Estrogen Receptors in the Macaque Reproductive Tract with Monoclonal Antiestrophilins*

1984 • 132 citations

Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concepts

1990 • 124 citations

An estrogen-responsive element mediates the transcriptional regulation of calbindin D-9K gene in rat uterus.

1991 • 115 citations

Estrogen receptor binding to a DNA response element in vitro is not dependent upon estradiol

1990 • 106 citations

Towards a new model for the mechanism of action of steroids

1982 • 94 citations

A single-stranded DNA-binding protein promotes the binding of the purified oestrogen receptor to its responsive element

1990 • 93 citations

Uterine Estrogen Receptor Interaction with Estrogen-Responsive DNA Sequencesin Vitro: Effects of Ligand Binding on Receptor-DNA Complexes

1990 • 73 citations

Chromatin structure, transcription, and methylation of the prolactin gene domain in pituitary tumors of Fischer 344 rats.

1984 • 60 citations

An Interaction between the 5′ Flanking Distal and Proximal Regulatory Domains of the Rat Prolactin Gene Is Required for Transcriptional Activation by Estrogens

1990 • 59 citations

Conformational transitions of the estrogen receptor monomer. Effects of estrogens, antiestrogen, and temperature.

1986 • 57 citations

Estrogen receptor transformation to a high-affinity state without subunit-subunit interactions

1984 • 47 citations

Expression of human estrogen receptor mutants in Xenopus oocytes: correlation between transcriptional activity and ability to form protein-DNA complexes.

1988 • 42 citations

Annual review of biochemistry

1980 • 41 citations

Cross-Linking of Estrogen Receptor to Chromatin in Intact MCF-7 Human Breast Cancer Cells: Optimization and Effect of Ligand

1990 • 40 citations

A twenty-two-fold increase in the relative affinity of estrogen receptor to poly (dA-dC).poly (dG-dT) in the presence of polyamines

1988 • 36 citations

Marked effects of salt on estrogen receptor binding to DNA: biologically relevant discrimination between DNA sequences

1991 • 35 citations

Anion binding to the chloride pump, halorhodopsin, and its implications for the transport mechanism

1990 • 34 citations

Unbound Progesterone Receptors Are in Equilibrium between the Nucleus and Cytoplasm in Cells of the Rat Uterus*

1981 • 30 citations

Estrogen Binding Is a Noncooperative Process in Primary Rat Uterine Cells*

1990 • 16 citations

Localization of an estrogen receptor binding site near the promoter of the uteroglobin gene

1990 • 15 citations

Interaction of Estradiol and Estriol with Uterine Estrogen Receptorin Vivoand in Excised Uteri or Cell Suspensions at 37 C: Noncooperative Estradiol Binding and Absence of Estriol Inhibition of Estradiol-Induced Receptor Activation and Transformation*

1985 • 14 citations

High affinity binding of estrogen receptor to recombinant plasmids containing (dA-dC)n.(dG-dT)n sequences.

1989 • 6 citations