Role of thrombospondin in the adhesion of human endothelial cells in primary culture

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Purification of fibronectin from human plasma by affinity chromatography under non-denaturing conditions

1979 • 553 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

How does extracellular matrix control capillary morphogenesis?

1989 • 466 citations

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

1990 • 407 citations

The structural and functional properties of thrombospondin

1986 • 333 citations

A Thrombin-Sensitive Protein of Human Platelet Membranes

1971 • 333 citations

Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography

1984 • 298 citations

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

1991 • 273 citations

Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix.

1983 • 266 citations

The structural and functional properties of thrombospondin

1986 • 261 citations

Thrombospondin: synthesis and secretion by cells in culture.

1982 • 259 citations

The properdin-like type I repeats of human thrombospondin contain a cell attachment site.

1991 • 238 citations

Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture. Apparent identity with platelet thrombospondin.

1981 • 216 citations

Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo.

1988 • 212 citations

Monocytes and macrophages synthesize and secrete thrombospondin

1985 • 208 citations

Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains.

1987 • 206 citations

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen.

1984 • 202 citations

Platelet thrombospondin mediates attachment and spreading of human melanoma cells.

1987 • 196 citations

Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: Interaction of thrombospondin with fibronectin and collagen

1982 • 177 citations

Specific inhibition of endothelial cell proliferation by thrombospondin

1990 • 168 citations

Thrombospondin is an osteoblast-derived component of mineralized extracellular matrix.

1989 • 130 citations

Optimized medium for clonal growth of human microvascular endothelial cells with minimal serum

1987 • 124 citations

Thrombospondin interactions with fibronectin and fibrinogen. Mutual inhibition in binding

1984 • 116 citations

Human brain glial cells synthesize thrombospondin.

1986 • 110 citations

The interaction of human platelet thrombospondin with fibrinogen. Thrombospondin purification and specificity of interaction.

1985 • 95 citations

Thrombospondin-induced adhesion of human keratinocytes.

1988 • 89 citations

Thrombospondin-induced adhesion of human platelets.

1991 • 62 citations

Thrombospondin inhibits adhesion of endothelial cells

1988 • 58 citations

Characterization of thrombospondin synthesis, secretion and cell surface expression by human tumor cells

1989 • 55 citations

Human Keratinocytes Synthesize and Secrete the Extracellular Matrix Protein, Thrombospondin

1987 • 50 citations

Thrombospondin: a component of microfibrils in various tissues.

1991 • 41 citations

Characterization of the binding of thrombospondin to human platelets and its association with the platelet cytoskeleton.

1991 • 33 citations

Thrombospondin inhibits adhesion of platelets to glass and protein-covered substrata.

1988 • 27 citations

The build-up of the thrombospondin extracellular matrix. An apparent dependence on synthesis and on preformed fibrillar matrix.

1988 • 22 citations

Structural and immunological comparison of human thrombospondins isolated from platelets and from culture supernatants of endothelial cells and fibroblasts

1986 • 22 citations

The proliferation of human umbilical vein endothelial cells in serum-free medium

1983 • 21 citations

Interactions of Thrombospondin with Cells in Culture: Rapid Degradation of Both Soluble and Matrix Thrombospondin

1987 • 21 citations

Thrombospondin inhibits adhesion of platelets to glass and protein- covered substrata

1988 • 18 citations

Characterization of an antibody directed against a 128 kDa glycoprotein involved in the thrombogenicity of the elastin-associated microfibrils.

1988 • 4 citations