Protein Kinase C α-mediated Negative Feedback Regulation Is Responsible for the Termination of Insulin-like Growth Factor I-induced Activation of Nuclear Phospholipase C β1 in Swiss 3T3 Cells

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

Rottlerin, a Novel Protein Kinase Inhibitor

1994 • 839 citations

A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export

1999 • 524 citations

The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase

1991 • 454 citations

A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control

2000 • 390 citations

Cloning and sequence of multiple forms of phospholipase C

1988 • 342 citations

Activation of Protein Kinase C Triggers Its Ubiquitination and Degradation

1998 • 333 citations

Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells

1992 • 321 citations

Phosphoinositide-specific phospholipase C and mitogenic signaling

1995 • 286 citations

Chemoattractant Receptor Cross-desensitization

1999 • 275 citations

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1985 • 274 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate.

1985 • 218 citations

Feedback regulation of phospholipase C-beta by protein kinase C.

1990 • 212 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

The Role of Carboxyl-terminal Basic Amino Acids in Gqα-dependent Activation, Particulate Association, and Nuclear Localization of Phospholipase C-β1

1996 • 198 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β1 is specifically, but not predominantly, located in the nucleus

1993 • 165 citations

A Role for Nuclear Phospholipase Cβ1 in Cell Cycle Control

2000 • 153 citations

βII Protein Kinase C Is Required for the G2/M Phase Transition of Cell Cycle

1996 • 143 citations

Protein Kinase C Isozyme-mediated Cell Cycle Arrest Involves Induction of p21 and p27 and Hypophosphorylation of the Retinoblastoma Protein in Intestinal Epithelial Cells

1997 • 143 citations

Nuclear diacylglycerol is increased during cell proliferation in vivo

1993 • 119 citations

A Role for Nuclear Phosphatidylinositol-specific Phospholipase C in the G2/M Phase Transition

1997 • 113 citations

Mammalian phosphoinositide-specific phospholipase C

1999 • 112 citations

Protein Kinase C-α Modulates Lipopolysaccharide-induced Functions in a Murine Macrophage Cell Line

1998 • 108 citations

Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells.

1994 • 108 citations

Two forms of phospholipase C-beta 1 generated by alternative splicing.

1994 • 106 citations

Nuclear Diacylglycerol Produced by Phosphoinositide-specific Phospholipase C Is Responsible for Nuclear Translocation of Protein Kinase C-α

1998 • 98 citations

Essential role for nuclear phospholipase C beta1 in insulin-like growth factor I-induced mitogenesis.

1997 • 89 citations

Role of Phospholipase Cβ3 Phosphorylation in the Desensitization of Cellular Responses to Platelet-activating Factor

1997 • 83 citations

Molecular Mechanism of the Inhibition of Phospholipase C β3 by Protein Kinase C

2000 • 83 citations

BiP (GRP78) and Endoplasmin (GRP94) Are Induced following Rotavirus Infection and Bind Transiently to an Endoplasmic Reticulum-Localized Virion Component

1998 • 79 citations

Homologous and heterologous regulation of receptor-stimulated phosphoinositide hydrolysis

1995 • 78 citations

Nuclear but not cytoplasmic phospholipase C beta 1 inhibits differentiation of erythroleukemia cells.

1998 • 76 citations

Antagonistic Effects of Protein Kinase C α and δ on Both Transformation and Phospholipase D Activity Mediated by the Epidermal Growth Factor Receptor

1999 • 76 citations

Localization of two forms of phospholipase C-β1, a and b, in C6Bu-1 cells

1998 • 76 citations

Growth factor‐induced cell division is paralleled by translocation of G _iα to the nucleus

1991 • 75 citations

Selective nuclear translocation of protein kinase C α in Swiss 3T3 cells treated with IGF‐I, PDGF and EGF

1994 • 62 citations

The G‐protein G _i regulates mitosis but not DNA synthesis in growth factor‐activated fibroblasts: a role for the nuclear translocation of G _i

1997 • 61 citations

Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures.

1989 • 47 citations

Nuclear inositides: inconsistent consistencies

2000 • 46 citations

Inositides in the nucleus: presence and characterisation of the isozymes of phospholipase β family in NIH 3T3 cells

1999 • 43 citations

G-protein βγ subunits antagonize protein kinase C-dependent phosphorylation and inhibition of phospholipase C-β1

1997 • 42 citations

Insulin-like growth factor-I-dependent stimulation of nuclear phospholipase C-?1 activity in Swiss 3T3 cells requires an intact cytoskeleton and is paralleled by increased phosphorylation of the phospholipase

1999 • 39 citations

Changes of Nuclear PI-PLC γ1 During Rat Liver Regeneration

1997 • 36 citations

Phosphorylation by protein kinase C decreases catalytic activity of avian phospholipase C-β

1999 • 35 citations

Contribution of phospholipase C-beta3 phosphorylation to the rapid attenuation of opioid-activated phosphoinositide response.

1998 • 30 citations

Inositol lipid cycle and autonomous nuclear signalling

1996 • 27 citations

Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle

1999 • 27 citations

The intranuclear amount of phospholipase C beta 1 decreases following cell differentiation in Friend cells, whereas gamma 1 isoform is not affected.

1995 • 23 citations

Inositides in the nucleus: taking stock of PLCβ1

1998 • 21 citations

Regulation of Phosphoinositide Phospholipases by G-Proteins

1997 • 20 citations

Immunocytochemical detection of the specific association of different PIC isoforms with cytoskeletal and nuclear matrix compartments in PC12 cells.

1994 • 15 citations

Increase of nuclear phosphatidylinositol 4,5-bisphosphate and phospholipase C β1 is not associated to variations of protein kinase C in multidrug-resistant Saos-2 cells

1997 • 11 citations