Gene silencing, cell fate and nuclear organisation

Chromosome territories, nuclear architecture and gene regulation in mammalian cells

2001 • 2,239 citations

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development

2002 • 708 citations

The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells

2001 • 673 citations

Drosophila Neuroblasts Sequentially Express Transcription Factors which Specify the Temporal Identity of Their Neuronal Progeny

2001 • 667 citations

Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes

1999 • 583 citations

Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets

2001 • 498 citations

Transcription complex stability and chromatin dynamics in vivo

1995 • 488 citations

Perinuclear localization of chromatin facilitates transcriptional silencing

1998 • 466 citations

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

1992 • 458 citations

Chromosome Dynamics in the Yeast Interphase Nucleus

2001 • 456 citations

Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei

2000 • 433 citations

Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions

1996 • 425 citations

Dynamic Repositioning of Genes in the Nucleus of Lymphocytes Preparing for Cell Division

1999 • 393 citations

Groucho-Mediated Transcriptional Repression Establishes Progenitor Cell Pattern and Neuronal Fate in the Ventral Neural Tube

2001 • 375 citations

Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus

2000 • 312 citations

Nuclear pore complexes in the organization of silent telomeric chromatin

2000 • 310 citations

Genetic modification of heterochromatic association and nuclear organization in Drosophila

1996 • 306 citations

Visualization of gene activity in living cells

2000 • 305 citations

Nuclear domains

2001 • 276 citations

Common Themes in Mechanisms of Gene Silencing

2001 • 275 citations

Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts

2000 • 270 citations

Different Levels of Repressor Activity Assign Redundant and Specific Roles to Nkx6 Genes in Motor Neuron and Interneuron Specification

2001 • 256 citations

Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

2000 • 250 citations

Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

2000 • 247 citations

Pax5/BSAP Maintains the Identity of B Cells in Late B Lymphopoiesis

2001 • 246 citations

A Functional Enhancer Suppresses Silencing of a Transgene and Prevents Its Localization Close to Centromeric Heterochromatin

1999 • 244 citations

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin

1998 • 244 citations

Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster.

1996 • 220 citations

LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes.

1991 • 203 citations

Ikaros Interactions with CtBP Reveal a Repression Mechanism That Is Independent of Histone Deacetylase Activity

2000 • 201 citations

Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes

2001 • 200 citations

Translocation of σ70 with RNA Polymerase during Transcription

2001 • 188 citations

Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator

2001 • 182 citations

Down-regulation of TDT transcription in CD4⁺CD8⁺thymocytes by Ikaros proteins in direct competition with an Ets activator

2001 • 151 citations

Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

2001 • 148 citations

Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells

2001 • 145 citations

Nuclear relocation of a transactivator subunit precedes target gene activation

2001 • 136 citations

Yeast heterochromatin is a dynamic structure that requires silencers continuously

2000 • 136 citations

Cracking the Transcriptional Code for Cell Specification in the Neural Tube

2001 • 135 citations

Positions of Potential:Nuclear Organization and Gene Expression

2001 • 134 citations

Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context- dependent manner

1999 • 124 citations

Transcription Factor Dosage Affects Changes in Higher Order Chromatin Structure Associated with Activation of a Heterochromatic Gene

2000 • 124 citations

Lineage commitment in lymphopoiesis

2000 • 98 citations

Dealing from the Evolutionary Pawnshop

1999 • 81 citations

Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei

1999 • 81 citations

Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene.

1993 • 62 citations