In Vivo Fluorescence Spectroscopy and Imaging for Oncological Applications

Handbook Of Biological Confocal Microscopy

2006 • 3,531 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Handbook of fluorescent probes and research chemicals

1996 • 2,829 citations

A review of the optical properties of biological tissues

1990 • 2,468 citations

The evolution of cancer of the colon and rectum

1975 • 2,120 citations

Photodynamic therapy with endogenous protoporphyrin

1990 • 1,519 citations

Photoradiation therapy for the treatment of malignant tumors.

1978 • 1,482 citations

New trends in photobiology

1992 • 1,194 citations

QUANTITATIVE OPTICAL SPECTROSCOPY FOR TISSUE DIAGNOSIS

1996 • 1,159 citations

Photophysical and photobiological processes in the photodynamic therapy of tumours

1997 • 1,078 citations

In Vivo Confocal Scanning Laser Microscopy of Human Skin: Melanin Provides Strong Contrast

1995 • 1,067 citations

5-Aminolevulinic acid-based photodynamic therapy

1997 • 992 citations

Photodynamic Therapy in Oncology: Mechanisms and Clinical Use

1993 • 755 citations

Intraoperative Detection of Malignant Gliomas by 5-Aminolevulinic Acid-induced Porphyrin Fluorescence

1998 • 661 citations

The Use of a Derivative of Hematoporphyrin in Tumor Detection<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 634 citations

Porphyrin localization and treatment of tumors

1985 • 633 citations

5‐Aminolevulinic Acid‐Based Photodynamic Therapy: Principles and Experimental Research

1997 • 630 citations

Mechanisms of Tumor Progression

2010 • 608 citations

Localization of Bronchial Intraepithelial Neoplastic Lesions by Fluorescence Bronchoscopy

1998 • 568 citations

Structure and Biodistribution Relationships of Photodynamic Sensitizers*

1996 • 506 citations

Monte Carlo modeling of light propagation in highly scattering tissues. I. Model predictions and comparison with diffusion theory

1989 • 473 citations

Laser induced fluorescence spectroscopy from native cancerous and normal tissue

1984 • 468 citations

Photodynamic therapy of non-melanoma malignant tumours of the skin using topical δ-amino levulinic acid sensitization and laser irradiation

1994 • 432 citations

Ultraviolet laser‐induced fluorescence of colonic tissue: Basic biology and diagnostic potential

1992 • 430 citations

Fluorescence lifetime imaging

1992 • 420 citations

Detection of Early Bladder Cancer by 5-Aminolevulinic Acid Induced Porphyrin Fluorescence

1996 • 417 citations

Implicit and explicit dosimetry in photodynamic therapy: a New paradigm

1997 • 400 citations

Detection of dysplasia and carcinoma in situ with a lung imaging fluorescence endoscope device

1993 • 390 citations

Hematoporphyrin Derivative: A Possible Aid in the Diagnosis and Therapy of Carcinoma of the Bladder

1976 • 384 citations

Autofluorescence of normal and malignant bronchial tissue

1991 • 383 citations

Raman Spectroscopy of Normal and Diseased Human Breast Tissues

1995 • 375 citations

Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy

1997 • 369 citations

Photoradiation in the Treatment of Recurrent Breast Carcinoma<xref ref-type="fn" rid="fn2">2</xref>

1979 • 367 citations

NOVEL THERAPEUTIC AND DIAGNOSTIC APPLICATIONS OF HYPOCRELLINS AND HYPERICINS

1995 • 362 citations

The Photodynamic Properties of a Particular Hematoporphyrin Derivative

1960 • 358 citations

Fluorescence spectra from cancerous and normal human breast and lung tissues

1987 • 346 citations

Photodynamic therapy with porfimer sodium versus thermal ablation therapy with Nd:YAG laser for palliation of esophageal cancer: a multicenter randomized trial

1995 • 336 citations

Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins

1987 • 306 citations

Analytical model for extracting intrinsic fluorescence in turbid media

1993 • 301 citations

Tumour microcirculation as a target for hyperthermia

1986 • 294 citations

Methylene blue selectively stains intestinal metaplasia in Barrett's esophagus

1996 • 283 citations

The Clinical Use of Fluorescein in Neurosurgery

1948 • 279 citations

Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture.

1997 • 275 citations

Fluorescence Photobleaching of ALA‐induced Protoporphyrin IX during Photodynamic Therapy of Normal Hairless Mouse Skin: The Effect of Light Dose and Irradiance and the Resulting Biological Effect

1998 • 272 citations

Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid

1994 • 270 citations

Oral versus intravenous administration of 5-aminolaevulinic acid for photodynamic therapy

1993 • 260 citations

In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence.

1994 • 258 citations

Endoscopic fluorescence detection of high-grade dysplasia in Barrett's esophagus

1996 • 251 citations

HEMATOPORPHYRIN DERIVATIVE: A NEW AID FOR ENDOSCOPIC DETECTION OF MALIGNANT DISEASE

1961 • 250 citations

Mathematical model for time-resolved and frequency-domain fluorescence spectroscopy in biological tissues

1994 • 250 citations

In vivofluorescence imaging for tissue diagnostics

1997 • 242 citations

Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study

1999 • 240 citations

Cervical Precancer Detection Using a Multivariate Statistical Algorithm Based on Laser‐Induced Fluorescence Spectra at Multiple Excitation Wavelengths

1996 • 237 citations

Time resolved imaging microscopy. Phosphorescence and delayed fluorescence imaging

1991 • 236 citations

The evolution of cancer of the colon and rectum

2010 • 234 citations

Roentgenographically Occult Lung Cancer: Pathologic Findings and Frequency of Multicentricity During a 10-Year Period

1984 • 232 citations

Laser-induced fluorescence spectroscopy of human colonic mucosa

1990 • 232 citations

Hematoporphyrin derivative for detection and management of cancer

1967 • 230 citations

Hematoporphyrin-Derivative Fluorescence in Malignant Neoplasms

1968 • 228 citations

Long-term survival after photodynamic therapy for esophageal cancer

1995 • 226 citations

Untersuchungen über die Rolle der Porphyrine bei geschwulstkranken Menschen und Tieren

1942 • 222 citations

Photodynamic Therapy: Basic Principles and Clinical Applications

1993 • 221 citations

SPECTROSCOPIC DIAGNOSIS OF COLONIC DYSPLASIA

1991 • 210 citations

Detection and Localization of Early Lung Cancer by Imaging Techniques

1993 • 209 citations

Porphyrins, porphyrias, cancer and photodynamic therapy — a model for carcinogenesis

1993 • 209 citations

Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats.

1992 • 206 citations

Raman, fluorescence, and time-resolved light scattering as optical diagnostic techniques to separate diseased and normal biomedical media

1992 • 202 citations

Prodrugs of 5‐Aminolevullinic Acid for Photodynamic Therapy

1996 • 195 citations

Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin

1955 • 187 citations

Side Effects and Photosensitization of Human Tissues after Aminolevulinic Acid

1997 • 183 citations

Initial assessment of a simple system for frequency domain diffuse optical tomography

1995 • 181 citations

FLUORESCENCE IMAGING AND POINT MEASUREMENTS OF TISSUE: APPLICATIONS TO THE DEMARCATION OF MALIGNANT TUMORS AND ATHEROSCLEROTIC LESIONS FROM NORMAL TISSUE

1991 • 179 citations

Fundamental Limits in Confocal Microscopy

1995 • 179 citations

Fluorescence spectroscopy of tissue: recovery of intrinsic fluorescence from measured fluorescence

1996 • 174 citations

Monte Carlo modeling of light propagation in highly scattering tissues. II. Comparison with measurements in phantoms

1989 • 172 citations

Propagation of fluorescent light

1997 • 171 citations

Imaging of fluorescent yield and lifetime from multiply scattered light reemitted from random media

1997 • 170 citations

Morphological model of human colon tissue fluorescence

1996 • 165 citations

New trends in photobiology

1994 • 165 citations

Fluorescence lifetime-based sensing and imaging

1995 • 163 citations

Inhalation of 5-aminolevulinic acid: a new technique for fluorescence detection of early stage lung cancer

1996 • 161 citations

Fluorescence Spectroscopy: A Diagnostic Tool for Cervical Intraepithelial Neoplasia (CIN)

1994 • 160 citations

Detection of dysplasia at colonoscopy using laser-induced fluorescence: a blinded study

1996 • 160 citations

DNA flow cytometry in solid tumors: practical aspects and clinical applications.

1989 • 156 citations

Build-up of esterified aminolevulinic-acid-derivative-induced porphyrin fluorescence in normal mouse skin

1996 • 153 citations

Detection and Localization of Early Lung Cancer by Imaging Techniques*

1991 • 153 citations

Fluorescence and Absorption Contrast Mechanisms for Biomedical Optical Imaging Using Frequency-Domain Techniques

1997 • 151 citations

Low-coherence optical tomography in turbid tissue: theoretical analysis

1995 • 151 citations

Early clinical experience with 5‐aminolevulinic acid for the photodynamic therapy of superficial bladder cancer

1996 • 150 citations

Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic treatment

1995 • 150 citations

CELLULAR FLUORESCENCE OF THE ENDOGENOUS PHOTOSENSITIZER PROTOPORPHYRIN IX FOLLOWING EXPOSURE TO 5‐AMINOLEVULINIC ACID

1995 • 149 citations

Endogenous porphyrin distribution induced by 5-aminolaevulinic acid in the tissue layers of the gastrointestinal tract

1993 • 147 citations

Photodetection and photodynamic therapy of ‘early’ squamous cell carcinomas of the pharynx, oesophagus and tracheo-bronchial tree

1990 • 145 citations

Lung cancer: Principles and practice

1997 • 144 citations

Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo

1996 • 142 citations

Slaked lime and betel nut cancer in Papua New Guinea

1992 • 141 citations

Iontophoretic Delivery of ALA Provides a Quantitative Model for ALA Pharmacokinetics and PpIX Phototoxicity in Human Skin

1997 • 141 citations

Characteristic autofluorescence for cancer diagnosis and its origin

1987 • 139 citations

Light dosimetryin vivo

1997 • 139 citations

Spectroscopic diagnosis of cervical intraepithelial neoplasia (CIN) in vivo using laser-induced fluorescence spectra at multiple excitation wavlengths

1996 • 136 citations

Clinical evaluation of a method for detecting superficial transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following topical application of 5-aminolevulinic acid: Preliminary results

1997 • 136 citations

In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices

1995 • 135 citations

Optical spectroscopic diagnosis of cancer and normal breast tissues

1989 • 135 citations

SPECTROSCOPIC AND MICROSCOPIC CHARACTERISTICS OF HUMAN SKIN AUTOFLUORESCENCE EMISSION

1995 • 134 citations

Role of delivery vehicles for photosensitizers in the photodynamic therapy of tumours

1997 • 132 citations

DOSE‐TIME DEPENDENCY OF TUMOR FORMATION BY CHRONIC UV EXPOSURE

1983 • 129 citations

Endogenous porphyrin fluorescence in tumors

1987 • 128 citations

Ultraviolet laser-induced fluorescence of colonic polyps.

1992 • 127 citations

Development of anIn Vivo Raman Spectroscopic System for Diagnostic Applications

1997 • 127 citations

Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid

1997 • 127 citations

Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice.

1994 • 126 citations

Laser-induced fluorescence spectroscopy at endoscopy: tissue optics, Monte Carlo modeling, and in vivo measurements

1995 • 125 citations

In vivo fluorescence kinetics and photodynamic therapy using 5-aminolaevulinic acid-induced porphyrin: increased damage after multiple irradiations

1994 • 124 citations

The effect of EDTA and serum on endogenous porphyrin accumulation and photodynamic sensitization of human K562 leukemic cells

1992 • 122 citations

Natural fluorescence of normal and neoplastic human colon: A comprehensive “ex vivo” study

1995 • 122 citations

Detection and localization of In situ carcinoma of the bladder with hematoporphyrin derivative.

1982 • 120 citations

Elastic scattering spectroscopy as a diagnostic tool for differentiating pathologies in the gastrointestinal tract: preliminary testing

1996 • 119 citations

Ultraviolet laser-induced fluorescence of colonic polyps

1992 • 119 citations

An optical phantom with tissue-like properties in the visible for use in PDT and fluorescence spectroscopy

1997 • 118 citations

Rapid multiexcitation fluorescence spectroscopy system for in vivo tissue diagnosis

1996 • 117 citations

Localization and Efficacy Analysis of the Phototherapeutic Lutetium Texaphyrin (PCI‐0123) in the Murine EMT6 Sarcoma Model

1997 • 117 citations

Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced Protoporphyrin IX for the dectection of neoplastic lesions in the oral cavity

1996 • 115 citations

Ten-year survival among patients with supratentorial astrocytomas grade III and IV

1988 • 112 citations

In vivo fluorescence spectroscopy and imaging of human skin tumours

1994 • 112 citations

Fluorescence Bronchoscopy for Detection of Lung Cancer

1979 • 112 citations

Uptake of the components of hematoporphyrin derivative by cells and tumours

1983 • 110 citations

Fluorescent diffuse photon density waves in homogeneous and heterogeneous turbid media: analytic solutions and applications

1996 • 110 citations

Rapid acquisition, analysis, and display of fluorescence lifetime-resolved images for real-time applications

1997 • 109 citations

New trends in photobiology

1990 • 109 citations

Study of the fluorescence properties of normal and neoplastic human cervical tissue

1993 • 109 citations

Diet, aberrant crypt foci and colorectal cancer

1993 • 108 citations

Photodynamic targeting of human retinoblastoma cells using covalent low-density lipoprotein conjugates

1997 • 108 citations

Fluorescence endoscopic imaging of human colonic adenomas

1996 • 108 citations

Autofluorescence characteristics of oral mucosa

1997 • 108 citations

A FLUORESCENCE IMAGING DEVICE FOR ENDOSCOPIC DETECTION OF EARLY STAGE CANCER – INSTRUMENTAL and EXPERIMENTAL STUDIES

1987 • 106 citations

Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen.

1992 • 104 citations

Breast cancer diagnosis using N2 laser excited autofluorescence spectroscopy

1997 • 103 citations

The frequency of a concomitant early esophageal cancer in male patients with oral and oropharyngeal cancer. Screening results using lugol dye endoscopy

1994 • 103 citations

Detection of Early Lung Cancer Using Low Dose Photofrin II

1990 • 103 citations

Fluorescence lifetime-based sensing in tissues: a computational study

1995 • 101 citations

Ability of specific monoclonal antibodies and conventional antisera conjugated to hematoporphyrin to label and kill selected cell lines subsequent to light activation.

1985 • 100 citations

Early Diagnosis of Upper Aerodigestive Tract Cancer by Autofluorescence

1996 • 100 citations

Fluorescence bronchoscopy for localization of carcinoma in situ

1983 • 99 citations

Laser-induced fluorescence microscopy of normal colon and dysplasia in colonic adenomas: implications for spectroscopic diagnosis.

1995 • 98 citations

Medical diagnostic system based on simultaneous multispectral fluorescence imaging

1994 • 98 citations

Photosensitizer targeting in photodynamic therapy I. Conjugates of haematoporphyrin with albumin and transferrin

1994 • 97 citations

In situ detection of melanomas by fluorescence measurements

1988 • 96 citations

Relation between fluorescence spectra of dilute and turbid samples

1994 • 96 citations

Role of neovasculature and vascular permeability on the tumor retention of photodynamic agents.

1992 • 94 citations

Diagnostic imaging of the larynx: autofluorescence of laryngeal tumours using the helium-cadmium laser

1995 • 94 citations

Laser fluorescence bronchoscope for localization of occult lung tumors

1979 • 92 citations

Photosensitizer targeting in photodynamic therapy II. Conjugates of haematoporphyrin with serum lipoproteins

1994 • 91 citations

Fourier Transform Multipixel Spectroscopy and Spectral Imaging of Protoporphyrin in Single Melanoma Cells

1996 • 90 citations

Early Detection of Lung Cancer by Means of Hematoporphyrin Derivative Fluorescence and Laser Photoradiation

1985 • 90 citations

Photodynamic therapy of tumours with hexadecafluoro zinc phthalocyanine formulated in PEG-coated poly(lactic acid) nanoparticles

1996 • 90 citations

Reconstruction of in vivo skin autofluorescence spectrum from microscopic properties by Monte Carlo simulation

1997 • 90 citations

Breast-duct endoscopy to study stages of cancerous breast disease

1996 • 87 citations

Detection of adenocarcinoma in Barrett's oesophagus by means of laser induced fluorescence.

1996 • 87 citations

Treatment of ovarian cancer with photodynamic therapy and immunoconjugates in a murine ovarian cancer model

1996 • 86 citations

Clinical pharmacokinetic studies of photofrin by fluorescence spectroscopy in the oral cavity, the esophagus, and the bronchi

1995 • 84 citations

Antibody–fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice

1991 • 84 citations

Loligomers: design of de novo peptide-based intracellular vehicles.

1995 • 83 citations

Laser Induced Autofluorescence Diagnosis of Bladder Cancer

1996 • 83 citations

Optimizing light dosimetry in photodynamic therapy of early stage carcinomas of the esophagus using fluorescence spectroscopy

1996 • 82 citations

Clinical recording of laser-induced fluorescence spectra for evaluation of tumour demarcation feasibility in selected clinical specialities

1991 • 81 citations

Further Evaluation of the Use of Hematoporphyrin Derivative As a New Aid for the Endoscopic Detection of Malignant Disease* *From the Mayo Clinic and Mayo Foundation. This investigation was supported in part by Research Grant ASP-9880 from the National Institutes of Health, Public Health Service.

1964 • 80 citations

Photodynamic Therapy (PDT) and Photodiagnosis (PD) Using Endogenous Photosensitization Induced by 5-Aminolevulinic Acid (ALA): Current Clinical and Development Status

1996 • 79 citations

In vivo kinetics and spectra of 5-aminolaevulinic acid-induced fluorescence in an amelanotic melanoma of the hamster

1994 • 79 citations

Iris fluorescein angiography in clinical practice

1997 • 77 citations

Hematoporphyrin fluorescence: An aid in diagnosis of malignant neoplasms

1971 • 76 citations

Clinical fluorescence diagnosis of human bladder carcinoma following low dose photofrin injection

1993 • 76 citations

Laser excited fluorescence of hematoporphyrin derivative for diagnosis of cancer

1984 • 74 citations

Quantification of the hematoporphyrin derivative by fluorescence measurement using dual-wavelength excitation and dual-wavelength detection

1993 • 74 citations

Tumor Detection and Visualization Using Cyanine Fluorochrome-Labeled Antibodies

1997 • 74 citations

Fluorescence Lifetime Imaging of Experimental Tumors in Hematoporphyrin Derivative‐Sensitized Mice

1997 • 73 citations

Localization of lipoprotein-delivered benzoporphyrin derivative in the rabbit eye

1997 • 73 citations

Validity of Ear Oximetry in Clinical Exercise Testing

1987 • 73 citations

Native fluorescence of the cervix uteri as a marker for dysplasia and invasive carcinoma

1989 • 72 citations

Pharmacokinetics and Body Distribution of Liposomal Zinc Phthalocyanine in Tumor‐Bearing Mice: Influence of Aggregation State, Particle Size, and Composition

1995 • 70 citations

A feasibility study of the use of fluorescence bronchoscopy for localization of small lung tumours

1977 • 70 citations

A microfluorometric scanning method for the detection of cancer cells in smears of exfoliated cells

1952 • 70 citations

Novel photodynamic effects of a benzophenothiazine on two different murine sarcomas.

1994 • 70 citations

Hypericin in phototherapy

1996 • 70 citations

Tissue Spectroscopy for Gastrointestinal Diseases

1996 • 69 citations

Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues

1997 • 69 citations

The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy

1996 • 68 citations

Photobleaching during and re-appearance after photodynamic therapy of topical ALA-induced fluorescence in UVB-treated mouse skin

1997 • 67 citations

Detection of hematoporphyrin fluorescence during fiberoptic bronchoscopy to localize early bronchogenic carcinoma.

1978 • 67 citations

Fluorescence photography as a diagnostic method for oral cancer

1996 • 67 citations

Light-induced fluorescence spectroscopy of adenomas, adenocarcinomas and non-neoplastic mucosa in human colon I. In vitro measurements

1992 • 67 citations

Effect of multiple light scattering and self-absorption on the fluorescence and excitation spectra of dyes in random media

1994 • 66 citations

Photodynamic therapy for polyps in familial adenomatous polyposis—a pilot study

1995 • 66 citations

PHOTOOXIDATION AND SINGLET OXYGEN SENSITIZATION BY PROTOPORPHYRIN IX AND ITS PHOTOOXIDATION PRODUCTS

1982 • 66 citations

Fluorescence microscopy

1991 • 66 citations

Laser-induced fluorescence: experimental intraoperative delineation of tumor resection margins

1992 • 65 citations

Use of hematoporphyrin derivative in detection and management of cervical cancer

1967 • 65 citations

Molecular luminescence spectroscopy

1994 • 65 citations

Clinical Evaluation of the Cutaneous Phototoxicity of 5,10,15,20‐Tetra (m‐hydroxyphenyl)chlorin

1998 • 65 citations

Photodynamic Therapy of Subretinal Neovascularization in the Monkey Eye

1993 • 63 citations

Laser Induced Autofluorescence Diagnosis of Bladder Tumors: Dependence on the Excitation Wavelength

1996 • 63 citations

Fluorescence Cystoscopy following Intravesical Instillation of 5-Aminolevulinic Acid: A New Procedure with High Sensitivity for Detection of Hardly Visible Urothelial Neoplasias

1995 • 63 citations

Kinetics and localisation of PpIX fluorescence after topical and systemic ALA application, observed in skin and skin tumours of UVB-treated mice

1996 • 62 citations

Fluorescence studies of hematoporphyrin derivative in normal and malignant rat tissue.

1986 • 62 citations

TIME‐GATED FLUORESCENCE IMAGING FOR THE DIAGNOSIS OF TUMORS IN A MURINE MODEL

1993 • 62 citations

The use of Fundus Photographs and Fluorescein Angiograms in the Identification and Treatment of Choroidal Neovascularization in the Macular Photocoagulation Study

1989 • 61 citations

Optically Dilute, Absorbing, and Turbid Phantoms for Fluorescence Spectroscopy of Homogeneous and Inhomogeneous Samples

1993 • 61 citations

In vivo fluorescence spectroscopy: potential for non-invasive, automated diagnosis of cervical intraepithelial neoplasia and use as a surrogate endpoint biomarker.

1994 • 58 citations

Malignancies and atherosclerotic plaque diagnosis—is laser induced fluorescence spectroscopy the ultimate solution?

1995 • 57 citations

In vivo damage to chorioallantoic membrane blood vessels by porphycene-induced photodynamic therapy

1995 • 57 citations

Time-resolved in-vivo fluorescence of photosensitizing porphyrins

1993 • 57 citations

Photodynamic Therapy of 9L Gliosarcoma with Liposome‐Delivered Photofrin

1997 • 57 citations

Investigative Urology: Biodistribution and Phototoxicity of 5-Aminolevulinic Acid-Induced PpIX in an Orthotopic Rat Bladder Tumor Model

1995 • 56 citations

Tetra(m-hydroxyphenyl)chlorin clinical photodynamic therapy of early bronchial and oesophageal cancers

1996 • 56 citations

Sensitization and photodynamic therapy (PDT) of gastrointestinal tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX). A pilot study.

1995 • 55 citations

Fluorometer for endoscopic diagnosis of tumors

1984 • 54 citations

Time-resolved multichannel imaging of fluorescent objects embedded in turbid media

1995 • 54 citations

Fundus imaging in patients with cataract: role for a variable wavelength scanning laser ophthalmoscope.

1995 • 54 citations

Difficulties in diagnosis of supratentorial gliomas by CAT scan.

1979 • 53 citations

Phthalocyanine photodynamic therapy: New strategy for closure of choroidal neovascularization

1994 • 53 citations

In Vivo Fluence Rate Effect in Photodynamic Therapy of Early Cancers with Tetra(m‐hydroxyphenyl)chlorin

1996 • 53 citations

Clinical results of photodynamic therapy for superficial skin malignancies or actinic keratosis using topical 5-aminolaevulinic acid

1996 • 52 citations

A model for extraction of diagnostic information from laser induced fluorescence spectra of human artery wall

1989 • 52 citations

Fluorescence detection of tumors early diagnosis of microscopic lesions in preclinical studies

1993 • 51 citations

Photodynamic Therapy for Choriocapillaris Using Tin Ethyl Etiopurpurin (SnET2)

1997 • 50 citations

Clinical pharmacokinetic studies of tetra(meta‐hydroxyphenyl)chlorin in squamous cell carcinoma by fluorescence spectroscopy at 2 wavelengths

1995 • 50 citations

Significance of Autofluorescence for the Optical Demarcation of Field Cancerisation in the Upper Aerodigestive Tract

1997 • 50 citations

Comparison of methods to determine chromophore concentrations from fluorescence spectra of turbid samples

1996 • 49 citations

Pulsed and cw laser fluorescence spectra from cancerous, normal, and chemically treated normal human breast and lung tissues

1989 • 49 citations

Carotenoporphyrins as selective photodiagnostic agents for tumours

1994 • 49 citations

Pharmacokinetics of 5-aminolevulinic-acid-induced porphyrins in tumour-bearing mice

1996 • 49 citations

Detecting Lung Cancer as a Cause of Hemoptysis in Patients with a Normal Chest Radiograph

1997 • 48 citations

In vivo fluorescence in clinical oncology: fundamental and practical issues

1992 • 48 citations

Prognostic Factors in Superficial Bladder Cancer

1992 • 48 citations

Argon Laser Induced Autofluorescence May Distinguish Between Normal and Tumor Human Urothelial Cells: A Microspectrofluorimetric Study

1996 • 48 citations

Fluorescence-lifetime determination in tissues or other scattering media from measurement of excitation and emission kinetics

1996 • 47 citations

Ultraviolet laser-induced fluorescence of human stomach tissues: Detection of cancer tissues by imaging techniques

1997 • 46 citations

Photofrin accumulation in malignant and host cell populations of various tumours

1996 • 46 citations

Detection of squamous cell cancer and pre-cancerous lesions by imaging of tissue autofluorescence in the hamster cheek pouch model

1992 • 45 citations

Distribution and photodynamic effects of meso-tetrahydroxyphenylchlorin (mTHPC) in the pancreas and adjacent tissues in the Syrian golden hamster

1996 • 45 citations

Digital background subtraction for fluorescence imaging

1986 • 45 citations

In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes

1994 • 45 citations

Precision localization of hidden absorbers in body tissues with phased-array optical systems

1996 • 44 citations

Potential applications of lifetime-based, phase-modulation fluorimetry in bioprocess and clinical monitoring

1995 • 44 citations

The use of time-resolved fluorescence for diagnosis of atherosclerotic plaque and malignant tumours

1990 • 44 citations

<title>In-vivo measurement of fluorescence bleaching of meso-tetra hydroxy phenyl chlorin (mTHPC) in the esophagus and the oral cavity</title>

1995 • 43 citations

Selective photosensitizer localization in the human endometrium after intrauterine application of 5-aminolevulinic acid

1996 • 43 citations

Light and drug distribution with topically administered photosensitizers

1996 • 42 citations

Influence of the emission–reception geometry in laser-induced fluorescence spectra from turbid media

1998 • 42 citations

Differences in laser-induced autofluorescence between adenomatous and hyperplastic polyps and normal colonic mucosa by confocal microscopy

1995 • 41 citations

Fiberoptic bronchoscopic photoradiation in experimentally induced canine lung cancer

1983 • 41 citations

Endoscopic system for simultaneous visual examination and electronic detection of fluorescence

1980 • 41 citations

Fluorescence Detection of the Anticancer Drug Topotecan in Plasma and Whole Blood by Two-Photon Excitation

1996 • 40 citations

Innate cellular fluorescence reflects alterations in cellular proliferation

1997 • 40 citations

Porphyrins Preferentially Accumulate in a Melanoma Following Intravenous Injection of 5-Aminolevulinic Acid

1997 • 40 citations

Fluorophore quantitation in tissue-simulating media with confocal detection

1996 • 39 citations

Detection of Early Stages of Carcinogenesis in Adenomas of Murine Lung by 5‐Aminolevulinic Acid‐Induced Protoporphyrin IX Fluorescence

1996 • 39 citations

Photodynamic diagnosis in respiratory tract malignancy using an excimer dye laser system

1990 • 39 citations

Evaluation of spectral correction techniques for fluorescence measurements on pigmented lesions in vivo

1996 • 38 citations

Endoscopic tissue characterization by frequency-domain fluorescence lifetime imaging (FD-FLIM)

1997 • 37 citations

7,12‐Dimethylbenz[a]anthracene‐induced ‘early’ squamous cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with ‘early’ forms of human squamous cell carcinoma in the upper aero‐digestive tract

1996 • 37 citations

Porphyrin Fluorescence and Photosensitization in Head and Neck Cancer

1986 • 37 citations

HEMATOPORPHYRINE DERIVATIVE FOR DETECTION OF CERVICAL CANCER.

1964 • 37 citations

Fluorescence diagnosis and photochemical treatment of diseased tissue using lasers: Part I

1989 • 37 citations

Laser-Induced Differential Fluorescence for Cancer Diagnosis without Biopsy

1997 • 37 citations

Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an amelanotic melanoma in vivo

1997 • 36 citations

Light propagation in animal tissues in the wavelength range 375-825 nanometers.

1984 • 36 citations

Reoxygenation of tumours in “sandwich” chambers

1979 • 36 citations

Photosensitization of the rat endometrium following 5-aminolevulinic acid induced photodynamic therapy

1996 • 35 citations

<title>How photobleaching affects dosimetry and fluorescence monitoring of PDT in turbid media</title>

1993 • 35 citations

Photophysical and Redox Properties of a Series of Phthalocyanines: Relation with Their Photodynamic Activities on TF‐1 and Daudi Leukemic Cells

1996 • 35 citations

LIPOPROTEIN‐MEDIATED DISTRIBUTION OF N‐ASPARTYL CHLORIN‐E6 IN THE MOUSE

1992 • 35 citations

Characterization of tumorous and normal tissue using a pH-sensitive fluorescence indicator (5,6-carboxyfluorescein) in vivo

1992 • 34 citations

Optimizing light dosimetry in photodynamic therapy of the bronchi by fluorescence spectroscopy

1996 • 33 citations

Use of hematoporphyrin fluorescence in biliary and cancer surgery.

1955 • 33 citations

Targeting of the tumor microcirculation by photodynamic therapy with a synthetic porphycene

1997 • 33 citations

EVALUATION OF NEW BENZOPORPHYRIN DERIVATIVES WITH ENHANCED PDT EFFICACY*

1995 • 33 citations

Distribution and Excretion of Radiolabeled Temoporfin in a Murine Tumor Model

1996 • 33 citations

Native cellular fluorescence can identify changes in epithelial thickness in-vivo in the upper aerodigestive tract

1995 • 32 citations

Detection of squamous neoplasia by fluorescence imaging comparing porfimer sodium fluorescence to tissue autofluorescence in the hamster cheek-pouch model

1995 • 32 citations

The two-photon laser-induced fluorescence of the tumor-localizing photosensitizer hematoporphyrin derivative. Resonance-enhanced 750 nm two-photon excitation into the near-UV Soret band.

1986 • 31 citations

Mechanism of photosensitization by microsphere-bound chlorin e6 in human bladder carcinoma cells.

1991 • 31 citations

Three-dimensional reconstruction by confocal laser scanning microscopy in routine pathologic specimens of benign and malignant lesions of the human breast

1997 • 30 citations

Fluorescence endoscopy instrumentation for improved tissue characterization

1987 • 30 citations

TUMOR‐LOCALIZING FLUORESCENT DIAGNOSTIC AGENTS WITHOUT PHOTOTOXICITY

1994 • 28 citations

In vivo FLUORESCENCE KINETICS OF PHTHALOCYANINES IN A SKIN‐FOLD OBSERVATION CHAMBER MODEL: ROLE OF CENTRAL METAL ION AND DEGREE OF SULFONATION

1993 • 28 citations

Tissue autofluorescence as an intermediate endpoint in NMBA-induced esophageal carcinogenesis

1994 • 28 citations

Detection of lung cancer by ratio fluorometry with and without Photofrin II

1990 • 27 citations

Laser-induced fluorescence in malignant and normal tissue in mice injected with two different carotenoporphyrins

1994 • 27 citations

Identification of brain tumours in rats using laser-induced fluorescence and haematoporphyrin derivative

1989 • 27 citations

Fluorescence bronchoscopy in the localization of bronchogenic carcinoma

1982 • 27 citations

The Digital Indocyanine Green Videoangiography Characteristics of Well-defined Choroidal Neovascularization

1995 • 26 citations

Delayed observation of laser-induced fluorescence for imaging of tumors

1993 • 26 citations

Fluorescence and photodynamic effects of bacteriochlorin a observed in vivo in 'sandwich' observation chambers

1993 • 26 citations

The alkyl-lysophospholipid, ET-18-OCH3 synergistically enhances the Merocyanine 540-mediated photoinactivation of leukemia cells: implications for the extracorporeal purging of autologous hematopoietic stem cells

1997 • 26 citations

Mathematical description of photobleachingin vivodescribing the influence of tissue optics on measured fluorescence signals

1997 • 26 citations

Evaluation of porfimer sodium fluorescence for measuring tissue transformation

1993 • 25 citations

Photodynamic activities and biodistribution of fluorinated zinc phthalocyanine derivatives in the murine EMT-6 tumour model

1997 • 25 citations

Ocular fluorometry: Principles, fluorophores, instrumentation, and clinical applications

1989 • 25 citations

Laser-induced fluorescence studies of normal and malignant tumour tissue of rat following intravenous injection of δ-amino levulinic acid

1997 • 25 citations

Fluorescence localization in tumour and normal brain after intratumoral injection of haematoporphyrin derivative into rat brain tumour

1995 • 24 citations

In vivo fluorescence kinetics and localisation of aluminium phthalocyanine disulphonate in an autologous tumour model

1996 • 24 citations

Diagnostic fluorescence spectroscopy of oral mucosa

1995 • 24 citations

Spectroscopic detection of oral and skin tissue transformation in a model for squamous cell carcinoma: autofluorescence versus systemic aminolevulinic acid-induced fluorescence

1996 • 24 citations

An endoscopic fluorescence imaging system for simultaneous visual examination and photodetection of cancers

1997 • 23 citations

Study of porphyrin fluorescence in tissue samples of tumour-bearing mice

1995 • 23 citations

FLUORESCENCE DIAGNOSIS AND PHOTOCHEMICAL TREATMENT OF DISEASED TISSUE USING LASERS: PART II

1990 • 23 citations

Frequency-domain fluorescence lifetime imaging for endoscopic clinical cancer photodetection: Apparatus design and preliminary results

1997 • 23 citations

Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II

1997 • 22 citations

Spectral characterization of the benzoporphyrin derivative monoacid ring— A photoproduct formed in fetal calf solutions during irradiation with 694 nm continuous-wave radiation

1996 • 22 citations

In vivo photo-detection of chemically induced premalignant lesions and squamous cell carcinoma of the rat palatal mucosa

1997 • 22 citations

Fluorescent diagnosis of experimental gastric cancer using a tumor-localizing photosensitizer

1997 • 22 citations

A system for real time fluorescence imaging in color for tumor diagnosis

1987 • 22 citations

Clinical assessment of fluorescence cystoscopy during transurethral bladder resection in superficial bladder cancer

1997 • 22 citations

5-aminolevulinic acid (ALA)-induced protoporphyrin IX fluorescence and photodynamic effects in the rat bladder: An in vivo study comparing oral and intravesical ALA administration

1997 • 21 citations

Measurements by fluorescence microscopy of the time-dependent distribution of meso-tetra-hydroxyphenylchlorin in healthy tissues and chemically induced “early” squamous cell carcinoma of the Syrian hamster cheek pouch

1996 • 21 citations

Cystoscopic Fluorescence Detector for Photodetection of Bladder Carcinoma with Hematoporphyrin Derivative

1984 • 21 citations

Fluorescence of HpD for tumor detection and dosimetry in photoradiation therapy.

1984 • 20 citations

Photodetection of early cancer by laser-induced fluorescence of a tumor-selective dye: apparatus design and realization

1990 • 19 citations

In vivo Laser‐induced Fluorescence Imaging of a Rat Pancreatic Cancer with Pheophorbide‐a

1997 • 19 citations

In vivo fluorescence kinetics of porphyrins following intravesical instillation of 5-aminolaevulinic acid in normal and tumour-bearing rat bladders

1997 • 18 citations

Vital staining of oesophagus in patients with head and neck cancer: still a worthwhile procedure.

1991 • 18 citations

Polarization Filter for Biomedical Tissue Optical Imaging

1997 • 17 citations

<title>Fluorescence detection of tumors: studies on the early diagnosis of microscopic lesions in preclinical and clinical studies</title>

1991 • 17 citations

Tumour visualization in a murine model by time-delayed fluorescence of sulphonated aluminium phthalocyanine

1997 • 17 citations

Distribution of aluminum phthalocyanine disulfonate in an oral squamous cell carcinoma model. In vivo fluorescence imaging compared with ex vivo analytical methods.

1997 • 17 citations

Laser-induced Fluorescence During Photorefractive Keratectomy: A Method for Controlling Epithelial Removal

1997 • 17 citations

<title>Photodetection of early cancer in the upper aerodigestive tract and the bronchi using photofrin II and colorectal adenocarcinoma with fluoresceinated monoclonal antibodies</title>

1991 • 16 citations

In vivo optical coherence tomography of human skin microstructure

1994 • 16 citations

Multifocalité du carcinome épidermoïde sur les voies digestive supérieure et respiratoire distale: technicité du diagnostic endoscopique

1981 • 16 citations

Cancer detection and therapy. III. Affinity of lymphatic tissues for hematoporphyrin.

1953 • 15 citations

<title>Confocal fluorescence microscopy, microspectrofluorimetry, and modeling studies of laser-induced fluorescence endoscopy (LIFE) of human colon tissue</title>

1997 • 15 citations

Localization and treatment of transformed tissues using the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a

1996 • 15 citations

<title>Fluorescence diagnostics of head and neck cancer utilizing oral administration of delta-amino levulinic acid</title>

1994 • 13 citations

FLUORESCENCE SPECTRA IN LUNG WITH PORPHYRIN INJECTION

1989 • 13 citations

Photodynamic Imaging of a Rat Pancreatic Cancer with Pheophorbide a

1996 • 13 citations

Optical Tissue Biodiagnostics Using Fluorescence Lifetime

1996 • 13 citations

Wavelength-dependent effect of tetra(m-hydroxyphenyl)chlorin for photodynamic therapy in an ‘early’ squamous cell carcinoma model

1997 • 12 citations

Digital Angiography of Experimental Choroidal Melanomas Using Benzoporphyrin Derivative

1997 • 12 citations

Indocyanine Green Videoangiography for the Imaging of Choroidal Neovascularization Associated with Macular Degeneration

1994 • 11 citations

<title>Clinical comparison of the pharmacokinetics of m-THPC and Photofrin II as observed by light-induced fluorescence</title>

1994 • 11 citations

<title>Imaging of tumors by time-delayed laser-induced fluorescence</title>

1991 • 11 citations

3339 Diagnosis of early gastric cancers by an endoscopic autofluorescence imaging system.

2000 • 11 citations

Diagnosis of early gastric cancers by an endoscopic autofluorescence imaging system

1997 • 11 citations

Further appraisal of PDI and PDT of early squamous cell carcinomas of the pharynx, oesophagus and bronchi

1992 • 10 citations

<title>Fluorescence excitation and emission spectra of ALA-induced protoporphyrin IX in normal and tumoral tissue of the human bladder</title>

1995 • 10 citations

Spectral variations of laser-induced tissue emission during in vivo detection of malignancies in the female genital tract

1997 • 9 citations

Endoscopic frequency-domain fluorescence lifetime imaging for clinical cancer photodetection: apparatus design

1995 • 9 citations

Laser-induced fluorescence detection of stomach cancer using hypericin

1996 • 9 citations

Tissue characterization by time-resolved fluorescence spectroscopy of endogenous and exogenous fluorochromes: apparatus design and preliminary results

1996 • 9 citations

Real time light induced fluorescence endoscopy (life) in the gastrointestinal (GI) tract

1997 • 8 citations

Fluorescent diagnostics of human gastric cancer and sodium fluorescein accumulation in experimental gastric cancer in rats

1993 • 8 citations

Fluorescence tomographical studies on breast tissue with Cancer

1990 • 8 citations

Study on the absorption properties of sulphonated aluminum phthalocyanine in vivo and ex vivo in murine tumor models

1997 • 8 citations

Laser-induced fluorescence detection of malignancies in the female genital tract via their natural emission and hypocrellin (HA) probing

1997 • 7 citations

<title>Endoscopic tissue autofluorescence measurements in the upper aerodigestive tract and the bronchi</title>

1991 • 7 citations

Endoscopic fluorescence detector

1988 • 7 citations

<title>Detection and characterization of chemical-induced abnormal tissue and rat tumors at different stages using fluorescence spectroscopy</title>

1996 • 6 citations

Laser-induced autofluorescence diagnosis of tumors

1997 • 6 citations

Computer-assisted fluorescence identification of colon cancer in rats.

1993 • 5 citations

<title>Spectral fluorescent properties of tissues in vivo with excitation in the red wavelength range</title>

1997 • 5 citations

<title>Fluorescence of normal and cancerous brain tissues: the excitation/emission matrix</title>

1994 • 5 citations

<title>Intraoperative metastases detection by laser-induced fluorescence spectroscopy</title>

1991 • 5 citations

Hematoporphyrin-derivative optical-fluorescence-detection instrument for localization of bladder and bronchous carcinoma i n s i t u

1986 • 5 citations

Fiber optic fluorescence detection of low-level porphyrin concentrations in preclinical and clinical studies

1990 • 4 citations

<title>Fluorescence imaging photodetection of early cancer in the bronchi with mTHPC and in the bladder with ALA-induced protoporphyrin IX: preliminary clinical results</title>

1994 • 4 citations

Photofrin II Pharmacokinetics and Optical Dosing in Tissue: Apparatus and Clinical Measurements for the Pharynx, Esophagus, and Tracheobronchial Tree

2020 • 3 citations

<title>Quantitative fluorescence measurements from tissue using confocal detection</title>

1997 • 3 citations

In Vivo Tissue Characterization Using Environmentally Sensitive Fluorochromes

1996 • 3 citations

Photodynamic Therapy for Choroidal Neovascularisation in Age-Related Macular Degeneration

1998 • 2 citations

Fiberoptic Fluorescence Detection Of Low Level Porphyrin Concentrations In Occult Metastases Of Lymph Nodes

1989 • 2 citations

Tucson Organizations Bring Optics into Schools

1996 • 2 citations

<title>Usefulness of fluorescence photodetection of neoplastic urothelial foci in bladder cancer following intravesical instillation of delta-aminolevulinic acid (5-ALA)</title>

1996 • 2 citations

Cancer detection by endoscopic frequency-domain fluorescence lifetime imaging

1998 • 1 citations

Breast cancer: in vitro measurements of native fluorescence

1996 • 1 citations

In Reply

1996 • 1 citations

Digital fundus imaging of subretinal neovascularization.

1992 • 1 citations

<title>Monitoring of benzoporphyrin derivative monoacid ring A (BPD-MA) in skin tumors by fluorescence during photodynamic therapy: preliminary observations</title>

1993 • 1 citations

Fluorescence photography: a diagnostic tool for the surgical setting.

1990 • 1 citations

System for fast measurement of in-vivo tissue fluorescence spectra under multiple wavelength excitations

1996 • 1 citations

Laser induced fluorescence endoscopy (life) during photodynamic therapy (PDT) for esophageal cancer

1997 • 1 citations

Deleted Work

1955 • 0 citations