NOVEL THERAPEUTIC AND DIAGNOSTIC APPLICATIONS OF HYPOCRELLINS AND HYPERICINS

Naturally Occurring Quinones

1971 • 1,283 citations

Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.

1988 • 450 citations

Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C.

1994 • 356 citations

HYPERICIN AND ITS PHOTODYNAMIC ACTION

1986 • 274 citations

Direct observation of fast proton transfer: femtosecond photophysics of 3-hydroxyflavone

1992 • 247 citations

Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation.

1993 • 240 citations

HYPOCRELLINS and THEIR USE IN PHOTOSENSITIZATION*

1990 • 211 citations

Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy.

1994 • 198 citations

HYPOCRELLIN, FROM HYPOCRELLA BAMBUASE, IS PHOTOTOXIC TO HUMAN IMMUNODEFICIENCY VIRUS

1994 • 187 citations

Photosensitization by anticancer agents 12. Perylene quinonoid pigments, a novel type of singlet oxygen sensitizer

1992 • 182 citations

Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin

1996 • 141 citations

PHOTOSENSITIZATION IS REQUIRED FOR INACTIVATION OF EQUINE INFECTIOUS ANEMIA VIRUS BY HYPERICIN

1991 • 140 citations

OXYGEN DEPENDENCE OF HYPERICIN‐INDUCED PHOTOTOXICITY TO EMT6 MOUSE MAMMARY CARCINOMA CELLS

1992 • 139 citations

Excited-state properties of hypericin: electronic spectra and fluorescence decay kinetics

1993 • 137 citations

Synthesis of polyketide-type aromatic natural products by biogenetically modeled routes

1977 • 136 citations

Phototherapeutic potential of alternative photosensitizers to porphyrins

1994 • 136 citations

Human immunodeficiency virus induces phosphorylation of its cell surface receptor

1988 • 133 citations

Photosensitization with anticancer agents 17. EPR studies of photodynamic action of hypericin: Formation of semiquinone radical and activated oxygen species on illumination

1993 • 121 citations

Naturally Occurring Quinones.

1958 • 120 citations

Pigments of fungi (Macromycetes)

2003 • 114 citations

A convenient semisynthetic route to hypericin

1993 • 111 citations

Hypericism

1980 • 107 citations

COMPARISON OF PHOTOCHEMOTHERAPY AND DITHRANOL IN THE TREATMENT OF CHRONIC PLAQUE PSORIASIS

1979 • 107 citations

Therapeutic potential of plant photosensitizers

1991 • 104 citations

Photosensitization with anticancer agents

1993 • 99 citations

Participation of Tyrosine Phosphorylation in the Cytopathic Effect of Human Immunodeficiency Virus-1

1992 • 98 citations

Observation of Excited-State Tautomerization in the Antiviral Agent Hypericin and Identification of Its Fluorescent Species

1994 • 93 citations

On the homo- and heteroassociation of hypericin

1994 • 93 citations

Photosensitization by hypericin: Electron spin resonance (ESR) evidence for the formation of singlet oxygen and superoxide anion radicals in an in vitro model

1994 • 91 citations

Formation d'oxygène singulet ₁Δ_g photosensibilisée par l'hypéricine. Étude cinétique en milieu micallaira non ionique

1988 • 85 citations

Totalsynthese des Hypericins

1957 • 82 citations

The gymnochromes: novel marine brominated phenanthroperylenequinone pigments from the stalked crinoid Gymnocrinus richeri

1991 • 80 citations

Inactivation of the Human Immunodeficiency Virus by Hypericin: Evidence for Photochemical Alterations of p24 and a Block in Uncoating

1992 • 77 citations

LASER PHOTOSENSITIZATION OF CELLS BY HYPERICIN

1994 • 76 citations

The importance of light in the anti-HIV effect of hypericin

1993 • 73 citations

Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin

1993 • 70 citations

Studies of the sulfonation of hypocrellin A and the photodynamic actions of the product

1993 • 69 citations

Hypocrellins as photosensitizers for photodynamic therapy: a screening evaluation and pharmacokinetic study

1996 • 68 citations

Role of Solvent in Excited-State Proton Transfer in Hypericin

1994 • 68 citations

Design, synthesis and investigation of mechanisms of action of novel protein kinase C inhibitors: perylenequinonoid pigments

1994 • 64 citations

Ultrafast excited-state processes in the antiviral agent hypericin

1993 • 64 citations

Pigments of fungi (macromycetes)

1994 • 63 citations

Acidic properties of hypericin and its octahydroxy analogue in the ground and excited states

1994 • 62 citations

Photosensitization with anticancer agents 13. The production of singlet oxygen by halogenated and metal-ion-chelated perylenequinones

1992 • 54 citations

Naturally Occurring Perylenequinones

1987 • 54 citations

EPR studies of singlet oxygen (1O2) and free radicals (O2.-, .OH, HB.-) generated during photosensitization of hypocrellin B

1993 • 50 citations

The Antiviral Agent Hypericin has in vitro Activity against HSV-1 Through Non-Specific Association with Viral and Cellular Membranes

1994 • 50 citations

Inhibition of duck hepatitis B virus replication by hypericin

1993 • 50 citations

Tautomerism and stereochemistry of hypericin: Force field, NMR, and X-ray crystallographic investigations

1993 • 49 citations

Formation d’oxygène singulet ¹Δ_g photosensibilisée par l’hypericine caractérisation et étude du mécanisme par spectroscopie laser

1987 • 49 citations

MEASUREMENT OF FORMAL POTENTIALS FOR HYPERICIN IN DIMETHYLSULFOXIDE

1993 • 46 citations

Relationship between photosensitizing activities and chemical structure of hypocrellin a and b

1992 • 44 citations

Studies on the chelation of hypocrellin A with aluminium ion and the photodynamic action of the resulting complex

1994 • 44 citations

Optically Active Total Synthesis of Calphostin D

1994 • 44 citations

Anthralin Decreases Keratinocyte TGF-α Expression and EGF-Receptor Binding In Vitro

1992 • 42 citations

Photosensitization with anticancer agents 14. Perylenequinonoid pigments as new potential photodynamic therapeutic agents: formation of tautomeric semiquinone radicals

1992 • 40 citations

Antiretroviral activities of hypericin and rose bengal: Photodynamic effects on Friend leukemia virus infection of mice

1993 • 39 citations

HYPERICIN PHOTOSENSITIZATION IN AQUEOUS MODEL SYSTEMS

1994 • 39 citations

Inhibition of epidermal growth factor receptor tyrosine kinase activity in A431 human epidermoid cells following psoralen/ultraviolet light treatment.

1989 • 38 citations

Propriétés du premier état triplet de l'hypericine. Étude par spectroscopie laser

1986 • 36 citations

Photosensitization by anticancer agents 21: New perylene- and aminonaphthoquinones

1996 • 35 citations

HYPERICIN DERIVED TRIPLET STATES and TRANSIENTS IN ALCOHOLS and WATER

1993 • 34 citations

Antiviral Assays on Phytochemicals: The Influence of Reaction Parameters

1994 • 34 citations

The role of oxygen in the photoinduced antiviral activity of hypericin

1994 • 32 citations

A simple high-yielding approach to perylenequinone from the novel one-step double coupling reaction of 1,2-naphtoquinone

1992 • 32 citations

Triplet-state reactions of hypericin: time-resolved laser photolysis and electron paramagnetic resonance spectroscopy

1993 • 32 citations

[Animal experiments on the psychotropic action of a Hypericum extract].

1987 • 30 citations

Photosensitization with anticancer agents. 18. Perylenequinonoid pigments as potential photodynamic therapeutic agents: preparation and photodynamic properties of amino-substituted hypocrellin derivatives.

1993 • 29 citations

GENERATION OF FREE RADICALS DURING PHOTOSENSITIZATION OF HYPOCRELLIN A AND THEIR EFFECTS ON CARDIAC MEMBRANES

1992 • 27 citations

Studies of the triplet state properties of hypocrellin A by nanosecond flash photolysis

1994 • 27 citations

Propriétés photophysiques de l’hypéricine en solution et en dispersion micellaire

1989 • 27 citations

Lowest excited triplet states of hypericin and isohypericin

1993 • 26 citations

On the tautomerism of hypericin: The 1,6-dioxo tautomer

1993 • 24 citations

Synthesis of Alkyl‐Substituted Helianthrones and Mesonaphthobianthrone by Highly Regioselective Photocyclization of Bianthronylidenes

1993 • 24 citations

On the bromination of hypericin: The gymnochrome chromophores

1993 • 24 citations

Laser-induced fluorescence detection of cardiovascular atherosclerotic deposits via their natural emission and hypocrellin (HA) probing

1994 • 23 citations

Autoextinction de la fluorescence et de l'absorption triplet-triplet de l'hypericine dans des liposomes de dipalmitoylphosphatidylcholine

1993 • 23 citations

Antitumor agents. 134. New shiraiachrome A and calphostin C-related perylene derivatives as cytotoxic and antiviral agents and inhibitors of protein kinase C

1992 • 23 citations

Application of a Cu(I)-mediated biaryl cross-coupling reaction to the synthesis of oxygenated 1,1′-binaphthalenes

1993 • 23 citations

Photosensitization with anticancer agents 19. EPR studies of photodynamic action of calphostin C: Formation of semiquinone radical and activated oxygen on illumination with visible light

1994 • 22 citations

Synthesis and biodistribution of 14C-radiolabelled hypocrellin B

1995 • 17 citations

Studies of sheep experimentally poisoned with Hypericum perforatum.

1993 • 16 citations

Time-resolved fluorescence spectroscopy and photolysis of the photoreceptor blepharismin

1993 • 16 citations

Photodynamic Inactivation of Radiation Leukemia Virus Produced from Hypericin-Treated Cells

1993 • 15 citations

A low-temperature Mitsunobu reaction for the inversion of sterically hindered secondary alcohols

1994 • 12 citations

Tautomerism and stereochemistry of dihydroxyperylenequinones: Force field investigations

1993 • 12 citations

Propriétés spectroscopiques et photophysiques de complexes métalliques de l’hypericine en relation avec leur activité photodynamique

1994 • 12 citations

Genetic Bill Vetoed

1991 • 11 citations

Photosensitization with anticancer agents 20—EPR studies on the photodynamic action of phleichrome: Formation of semiquinone radical and activated oxygen species on illumination with visible light

1995 • 11 citations

Transient uptake of hypericin by chrysomelids is regulated by feeding behaviour

1993 • 11 citations

Photosensitization with anticancer agents 16. The photo-oxidation of hypocrellin A. A mechanism study using 18O labelling

1993 • 10 citations

Stereochemistry and tautomerism of stentorin, isostentorin, and fringelit D: Force field investigations

1994 • 10 citations

THE EFFECTS OF ENVIRONMENTS ON THE FLUORESCENCE SPECTRUM OF HYPOCRELLIN A

1989 • 9 citations

Tautomerism and stereochemistry of isohypericin, bromohypericines, and gymnochromes: Force field investigations

1993 • 9 citations

Synthetic studies in novel hypocrellin B derivatives

1993 • 7 citations

Differential regulations of phosphatidylcholine biosynthesis in U937 cells by inhibitors of protein and tyrosine kinases

1994 • 6 citations

Some Synthetic Studies Related to Perylenequinones

1993 • 6 citations

<title>Intracellular uptake kinetics of hypocrellin photosensitizers for photodynamic therapy</title>

1994 • 6 citations

Treating AIDS With Worts

1991 • 5 citations

Study on the nanosecond transient absorption spectra of hypocrellin A.

1992 • 5 citations

Concerning the question of covalent bonding in hypericin-chromoproteins: Schiff base formation?

1994 • 5 citations

[The modification of a radiation lesion in animals with an aqueous extract of Hypericum perforatum L. 2].

1992 • 5 citations

Treating AIDS with Worts

1991 • 4 citations

Light and dark reactions of calphostin C and hypericin induce irreversible inactivation of protein kinase C by site-specific oxidations

1993 • 4 citations

THE ELECTRONIC SPECTRA OF HYPOCRELLINS A, B AND THEIR DERIVATIVES

1989 • 4 citations

[The use of an infusion of St.-John's-wort in the combined treatment of alcoholics with peptic ulcer and chronic gastritis].

1993 • 3 citations

One-Pot Preparation of 3-(2-Oxoalkyl)-1,2-naphthoquinones by Photochemical Reaction of 1,2-Naphthoquinones with Enol Ethers

1993 • 3 citations

[Hypocrellin B photosensitization effected a change of cytoplasmic free calcium concentration in ascitic hepatoma cells].

1993 • 2 citations

Molecular and Crystalline Structure of Conformational Isomer of Hypocrellin A

1993 • 1 citations

Deleted Work

1955 • 0 citations