Synergism of Xist Rna, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

1999 • 5,748 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

1991 • 1,469 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

1988 • 1,180 citations

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

1999 • 1,168 citations

Requirement for Xist in X chromosome inactivation

1996 • 995 citations

The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

1992 • 983 citations

DNA hypomethylation leads to elevated mutation rates

1998 • 935 citations

DNA methylation and gene activity

1988 • 904 citations

Structure and Function of a Human TAF _II 250 Double Bromodomain Module

2000 • 808 citations

XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure.

1996 • 787 citations

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

1996 • 784 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

1999 • 714 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

1997 • 705 citations

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

1993 • 692 citations

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

2001 • 687 citations

Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome

1991 • 617 citations

Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals

1998 • 591 citations

A Shift from Reversible to Irreversible X Inactivation Is Triggered during ES Cell Differentiation

2000 • 552 citations

Characterization of a murine gene expressed from the inactive X chromosome

1991 • 529 citations

Generating green fluorescent mice by germline transmission of green fluorescent ES cells

1998 • 479 citations

DNA hypomethylation can activate Xist expression and silence X-linked genes.

1996 • 377 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

Acetylation and chromosomal functions

2000 • 296 citations

The human X-inactivation centre is not required for maintenance of X-chromosome inactivation

1994 • 286 citations

Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos

1979 • 284 citations

X-Chromosome Inactivation in Cloned Mouse Embryos

2000 • 270 citations

X-Inactivation and Histone H4 Acetylation in Embryonic Stem Cells

1996 • 244 citations

Synergistic Effect of Histone Hyperacetylation and DNA Demethylation in the Reactivation of the FMR1 Gene

1999 • 214 citations

Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression

1995 • 183 citations

Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens.

1986 • 178 citations

Role of the Xist Gene in X Chromosome Choosing

1998 • 157 citations

Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant

2000 • 142 citations

X-chromosome inactivation: molecular mechanisms and genetic consequences

1994 • 141 citations

Methylation status of CpG-rich islands on active and inactive mouse X chromosomes

1991 • 114 citations

Detrimental effects of two active X chromosomes on early mouse development

1990 • 99 citations

Stabilization and Localization of Xist RNA are Controlled by Separate Mechanisms and are Not Sufficient for X Inactivation

1998 • 98 citations

5-Azacytidine-induced re-expression of alleles on the inactive X chromosome in a hybrid mouse cell line

1982 • 94 citations

Absence of the XIST gene from late-replicating isodicentric X chromosomes in leukaemia

1994 • 74 citations

Histone acetylation and X inactivation

1998 • 73 citations

Correlations between sex chromatin and sex chromosomes.

1962 • 70 citations

Recombinant Retroviruses Encoding Simian Virus 40 Large T Antigen and Polyomavirus Large and Middle T Antigens

1986 • 70 citations

DELAYED ONSET OF REPLICATION OF HUMAN X CHROMOSOMES

1967 • 68 citations

Factors Affecting de Novo Methylation of Foreign DNA in Mouse Embryonic Stem Cells

1999 • 45 citations

Reactivation of XIST in normal fibroblasts and a somatic cell hybrid: Abnormal localization of XIST RNA in hybrid cells

1998 • 44 citations