Susceptibility of Signal Transducer and Activator of Transcription-1-Deficient Mice to Pulmonary Fibrogenesis

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Regulation of PDGF and its receptors in fibrotic diseases

2004 • 697 citations

A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis

1999 • 585 citations

Stat1-dependent and -independent pathways in IFN-γ-dependent signaling

2002 • 545 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

2001 • 487 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Transcriptional regulation by MAP kinases

1995 • 431 citations

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

2001 • 420 citations

The V Protein of Simian Virus 5 Inhibits Interferon Signalling by Targeting STAT1 for Proteasome-Mediated Degradation

1999 • 416 citations

Principles and Practices of Unbiased Stereology: An Introduction for Bioscientists

2002 • 409 citations

Interferon-γ elicits arteriosclerosis in the absence of leukocytes

2000 • 375 citations

Biologic consequences of Stat1-independent IFN signaling

2001 • 345 citations

Molecular Mechanisms of Antifibrotic Effect of Interferon Gamma in Bleomycin-Mouse Model of Lung Fibrosis: Downregulation of TGF-β and Procollagen I and III Gene Expression

1995 • 306 citations

Activation of STAT proteins and growth control

2001 • 277 citations

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

2001 • 247 citations

Stat1-independent regulation of gene expression in response to IFN-γ

2001 • 243 citations

STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin

1996 • 165 citations

Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation

2001 • 146 citations

Expression of transforming growth factor-alpha and epidermal growth factor receptor is increased following bleomycin-induced lung injury in rats.

1994 • 144 citations

Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

1999 • 144 citations

Acute Respiratory Failure after Interferon-γ Therapy of End-Stage Pulmonary Fibrosis

2003 • 98 citations

IL‐13 and IL‐1β promote lung fibroblast growth through coordinated up‐regulation of PDGF‐AA and PDGF‐Rα

2004 • 79 citations

Role of interferon-γ in the evolution of murine bleomycin lung fibrosis

2003 • 74 citations

Quantitative Microscopic Analysis

1930 • 68 citations

Vanadium Stimulates Human Bronchial Epithelial Cells to Produce Heparin-Binding Epidermal Growth Factor–Like Growth Factor

2001 • 53 citations

Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases

2003 • 52 citations

Interferon-γ activates EGF receptor and increases TGF-α in T84 cells: implications for chloride secretion

2002 • 40 citations

The epidermal growth factor receptor at the crossroads of airway remodeling

2002 • 37 citations

PDGF stimulates tyrosine phosphorylation of JAK 1 protein tyrosine kinase in human mesangial cells

1996 • 34 citations

Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase

2003 • 29 citations

p38 Mitogen-Activated Protein Kinase Regulates Growth Factor–Induced Mitogenesis of Rat Pulmonary Myofibroblasts

2002 • 27 citations

Interferon-γ modulates lung macrophage production of PDGF-BB and fibroblast growth

1996 • 21 citations

Ineffectiveness of interferon-γ in the treatment of idiopathic myelofibrosis: a pilot study

2001 • 15 citations