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Pravastatin Limits Endothelial Activation after Irradiation and Decreases the Resulting Inflammatory and Thrombotic Responses

Data up to Jan 2025

Published2005
Citations115
References53

Total Citations Per Year

Abstract

References (53)

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Endothelial Dysfunction

2003 • 2,137 citations

Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

2001 • 1,245 citations

Intercellular adhesion molecule-1

1996 • 788 citations

Statin effects beyond lipid lowering—are they clinically relevant?

2003 • 526 citations

Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIbIIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), αvβ3 Integrin, and GPIbα

1998 • 417 citations

Endothelium-Dependent Effects of Statins

2003 • 412 citations

Late Coronary Occlusion After Intracoronary Brachytherapy

1999 • 397 citations

Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice

2000 • 393 citations

Simvastatin Reduces Expression of Cytokines Interleukin-6, Interleukin-8, and Monocyte Chemoattractant Protein-1 in Circulating Monocytes From Hypercholesterolemic Patients

2002 • 377 citations

Statins as anti-inflammatory agents

2002 • 335 citations

Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (Review).

1999 • 318 citations

Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect

2000 • 303 citations

Inhibition of Monocyte Chemotactic Protein-1 Synthesis by Statins

2000 • 300 citations

Statins prevent endothelial cell activation induced by antiphospholipid (anti-?2-glycoprotein I) antibodies: Effect on the proadhesive and proinflammatory phenotype

2001 • 265 citations

Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis

2000 • 223 citations

A new HMG‐CoA reductase inhibitor, rosuvastatin, exerts anti‐inflammatory effects on the microvascular endothelium: the role of mevalonic acid

2001 • 204 citations

Effects of Fluvastatin on Leukocyte–Endothelial Cell Adhesion in Hypercholesterolemic Rats

1997 • 198 citations

Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses

2003 • 198 citations

Current and future treatment of hyperlipidemia: the role of statins

1998 • 192 citations

HMG-CoA Reductase Inhibitor Modulates Monocyte–Endothelial Cell Interaction Under Physiological Flow Conditions In Vitro

2001 • 188 citations

Radiation-Induced Pulmonary Fibrosis: Examination of Chemokine and Chemokine Receptor Families

2002 • 174 citations

Radiation-induced normal tissue injury: Role of adhesion molecules in leukocyte-endothelial cell interactions

1999 • 166 citations

Pathophysiological effects of radiation on atherosclerosis development and progression, and the incidence of cardiovascular complications

2002 • 160 citations

Late and persistent up-regulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro

1997 • 159 citations

Modulation of inflammatory mediators and pparγand nfκb expression by pravastatin in response to lipoproteins in human monocytes in vitro

2002 • 153 citations

Deficiency of Microvascular Thrombomodulin and Up-Regulation of Protease-Activated Receptor-1 in Irradiated Rat Intestine

2002 • 152 citations

Hydroxymethylglutaryl Coenzyme A Reductase Inhibitors Modify the Inflammatory Response of Human Macrophages and Endothelial Cells Infected With Chlamydia pneumoniae

2000 • 150 citations

Simvastatin Reduces the Expression of Adhesion Molecules in Circulating Monocytes From Hypercholesterolemic Patients

2003 • 147 citations

E-Selectin Gene Induction by Ionizing Radiation Is Independent of Cytokine Induction

1995 • 128 citations

Statins differ in their ability to block NF-kB activation in human blood monocytes

2003 • 128 citations

Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy

2004 • 120 citations

Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats

1995 • 117 citations

Cerivastatin Suppresses Lipopolysaccharide-Induced ICAM-1 Expression through Inhibition of Rho GTPase in BAEC

2000 • 107 citations

Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy

2002 • 91 citations

Pravastatin down-regulates inflammatory mediators in human monocytes in vitro

2000 • 90 citations

Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation

2003 • 83 citations

Effects of Intercellular Adhesion Molecule 1 (ICAM-1) Null Mutation on Radiation-Induced Pulmonary Fibrosis and Respiratory Insufficiency in Mice

2002 • 82 citations

Ionizing radiation enhances IL‐6 and IL‐8 production by human endothelial cells

1997 • 75 citations

The Effect of Endovascular Irradiation on Platelet Recruitment at Sites of Balloon Angioplasty in Pig Coronary Arteries

2000 • 63 citations

Radiosensitivity of Vascular Tissue: II. Differential Radiosensitivity of Aortic Cells in Vitro

1984 • 61 citations

Irradiation enhances the support of haemopoietic cell transmigration, proliferation and differentiation by endothelial cells

2001 • 61 citations

Inflammatory Reaction and Changes in Expression of Coagulation Proteins on Lung Endothelial Cells after Total-Body Irradiation in Mice

2003 • 60 citations

Short-Term Inhibition of ADP-Induced Platelet Aggregation by Clopidogrel Ameliorates Radiation-Induced Toxicity in Rat Small Intestine

2002 • 51 citations

Characterization of the response of human bone marrow endothelial cells to in vitro irradiation

1998 • 47 citations

Radiation Injury in Rat Lung: III. Plasminogen Activator and Fibrinolytic Inhibitor Activities

1983 • 43 citations

Radiation Nephropathy&The Link Between Functional Damage and Vascular Mediated Inflammatory and Thrombotic Changes

2001 • 28 citations

HMG-CoA reductase inhibitor attenuates platelet adhesion in intestinal venules of hypercholesterolemic mice

2004 • 28 citations

Increased Expression of Glomerular von Willebrand Factor after Irradiation of the Mouse Kidney

1998 • 25 citations

Radiation effects on circulating and endothelial cell interactions studied by quantitative real-time videomicroscopy.

2002 • 25 citations

Statin use is associated with improved biochemical outcome after high-dose radiotherapy for clinically localized prostate cancer

2003 • 24 citations

Tepoxalin inhibits inflammation and microvascular dysfunction induced by abdominal irradiation in rats

2000 • 19 citations

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