Antifungal Resistance Trends Towards the Year 2000

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Amphotericin B: 30 Years of Clinical Experience

1990 • 1,011 citations

Increase inCandida kruseiInfection among Patients with Bone Marrow Transplantation and Neutropenia Treated Prophylactically with Fluconazole

1991 • 957 citations

Resistance of Candida species to fluconazole

1995 • 890 citations

Development of Interpretive Breakpoints for Antifungal Susceptibility Testing: Conceptual Framework and Analysis of In Vitro-In Vivo Correlation Data for Fluconazole, Itraconazole, and Candida Infections

1997 • 862 citations

A Comparison of Amphotericin B Alone and Combined with Flucytosine in the Treatment of Cryptoccal Meningitis

1979 • 850 citations

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

1995 • 805 citations

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

1997 • 608 citations

Antifungal agents: chemotherapeutic targets and immunologic strategies

1996 • 491 citations

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

1995 • 476 citations

Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

1996 • 407 citations

Lipid Formulations of Amphotericin B: Recent Progress and Future Directions

1996 • 400 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

Fungal Infections in Solid-Organ Transplantation

1993 • 388 citations

Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients

1993 • 352 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Epidemiology of oral candidiasis in HIV-infected patients: Colonization, infection, treatment, and emergence of fluconazole resistance

1994 • 321 citations

Trichosporon beigelii, an emerging pathogen resistant to amphotericin B

1990 • 314 citations

Infection Due to Penicillium marneffei, an Emerging Pathogen: Review of 155 Reported Cases

1996 • 305 citations

The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans

1997 • 291 citations

Management of Invasive Candidal Infections: Results of a Prospective, Randomized, Multicenter Study of Fluconazole Versus Amphotericin B and Review of the Literature

1996 • 281 citations

Cryptococcal Meningitis and AIDS

1993 • 280 citations

Resistance of Candida albicans to Fluconazole During Treatment of Oropharyngeal Candidiasis in a Patient with AIDS: Documentation by In Vitro Susceptibility Testing and DNA Subtype Analysis

1994 • 271 citations

Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance

1996 • 262 citations

Emergence of azole drug resistance in Candida species from HIV-infected patients receivingprolonged fluconazole therapy for oral candidosis

1995 • 257 citations

Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection

1994 • 254 citations

Comparative and collaborative evaluation of standardization of antifungal susceptibility testing for filamentous fungi

1995 • 252 citations

Collaborative comparison of broth macrodilution and microdilution antifungal susceptibility tests

1992 • 250 citations

Mode of Action of 5-Fluorocytosine and Mechanisms of Resistance

1975 • 244 citations

Amphotericin B-resistant yeast infection in severely immunocompromised patients

1988 • 236 citations

Evolving Role of Flucytosine in Immunocompromised Patients: New Insights into Safety, Pharmacokinetics, and Antifungal Therapy

1992 • 228 citations

Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia

1997 • 227 citations

Mode of action of antifungal agents

1984 • 221 citations

Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype

1994 • 218 citations

Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate

1991 • 208 citations

Characterization of an azole-resistant Candida glabrata isolate

1992 • 207 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Fluconazole Combined with Flucytosine for Treatment of Cryptococcal Meningitis in Patients with AIDS

1994 • 203 citations

Defective sterol C5-6 desaturation and azole resistance: A new hypothesis for the mode of action of azole antifungals

1989 • 200 citations

Genetic and Physiological Aspects of Resistance to 5-Fluoropyrimidines in Saccharomyces cerevisiae

1970 • 198 citations

Trichosporonosis in Patients with Neoplastic Disease

1986 • 197 citations

Fungal Infections in Lung and Heart-Lung Transplant Recipients: Report of 9 Cases and Review of the Literature

1996 • 193 citations

Azole resistance in Candida albicans.

1984 • 189 citations

Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits

1986 • 188 citations

Pradimicin, a novel class of potent antifungal antibiotics.

1988 • 186 citations

Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human

1979 • 183 citations

Flucytosine

1977 • 183 citations

Susceptibility testing of fungi: current status of correlation of in vitro data with clinical outcome

1996 • 168 citations

In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds

1997 • 166 citations

Genetics and biochemistry of yeast multidrug resistance

1994 • 157 citations

Long-term therapy of chronic mucocutaneous candidiasis with ketoconazole: Experience with twenty-one patients

1983 • 156 citations

Phase I trial of recombinant human macrophage colony-stimulating factor in patients with invasive fungal infections

1991 • 156 citations

Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1

1993 • 155 citations

Risk Factors for Fluconazole-Resistant Candidiasis in Human Immunodeficiency Virus-Infected Patients

1996 • 154 citations

Occurrence and characterization of acyclovir‐resistant herpes simplex virus isolates: Report on a two—year sensitivity screening survey

1992 • 151 citations

Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene

1994 • 149 citations

Beta-Lactam Antibiotics

1988 • 148 citations

Infection Due to Fluconazole-Resistant Candida in Patients with AIDS: Prevalence and Microbiology

1997 • 144 citations

Anti-CandidaDrugs — The Biochemical Basis for Their Activity

1987 • 142 citations

Therapeutic efficacy of monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan alone and in combination with amphotericin B

1994 • 140 citations

Use of amphotericin B with azole antifungal drugs: what are we doing?

1995 • 139 citations

Visceral fungal infections due to petriellidium boydii (allescheria boydii)

1976 • 139 citations

Fatal Disseminated Candidiasis Due to Amphotericin-B-Resistant Candida guilliermondii

1985 • 137 citations

Disseminated Zygomycosis in a Neutropenic Patient: Successful Treatment with Amphotericin B Lipid Complex and Granulocyte Colony-Stimulating Factor

1997 • 136 citations

Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata

1995 • 131 citations

Fatal septicemia due to amphotericin B-resistant Candida lusitaniae

1983 • 131 citations

A Mutation in Human Immunodeficiency Virus Reverse Transcriptase and Decline in CD4 Lymphocyte Numbers in Long-Term Zidovudine Recipients

1993 • 129 citations

Resistance to amphotericin B associated with defective sterolΔ^8→7isomerase in aCryptococcus neoformansstrain from an AIDS patient

1994 • 129 citations

In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans

1996 • 128 citations

The Development Of Resistance By Candida Species To Polyene Antibiotics In Vitro

1971 • 124 citations

Role of Granulocyte-Macrophage Colony-Stimulating Factor as Adjuvant Therapy for Fungal Infection in Patients with Cancer

1993 • 122 citations

In Vivo Interferon- Therapy Augments the In Vitro Ability of Chronic Granulomatous Disease Neutrophils to Damage Aspergillus Hyphae

1991 • 121 citations

Long-term follow-up of patients with invasive fungal disease who received adjunctive therapy with recombinant human macrophage colony- stimulating factor

1993 • 121 citations

Correlation between In Vitro and In Vivo Activity of Antifungal Agents against Candida Species

1994 • 120 citations

Candida albicans genotyping in studies with patients with AIDS developing resistance to fluconazole

1993 • 119 citations

5-Fluorocytosine Resistance in Cryptococcus neoformans

1973 • 111 citations

Detection and Significance of Fluconazole Resistance in Oropharyngeal Candidiasis in Human Immunodeficiency Virus-Infected Patients

1996 • 111 citations

Stable azole drug resistance associated with a substrain of Candida albicans from an HIV‐infected patient

1997 • 109 citations

Susceptibilities of serial Cryptococcus neoformans isolates from patients with recurrent cryptococcal meningitis to amphotericin B and fluconazole

1993 • 109 citations

Susceptibility to 5-fluorocytosine and prevalence of serotype in 402 Candida albicans isolates from the United States

1982 • 108 citations

Correlation of in Vitro Susceptibility Test Results with in Vivo Response: Flucytosine Therapy in a Systemic Candidiasis Model

1983 • 103 citations

The Lipid Composition of Azole-sensitive and Azole-resistant Strains of Candida albicans

1986 • 100 citations

Correlation between in vitro susceptibility ofCandida albicans and fluconazole-resistant oropharyngeal candidiasis in HIV-infected patients

1993 • 99 citations

Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance

1996 • 99 citations

Fluconazole-Resistant Candida albicans After Long-term Suppressive Therapy

1993 • 98 citations

Resistance to Polyene Antibiotics and Correlated Sterol Changes in Two Isolates of Candida tropicalis from a Patient with an Amphotericin B-resistant Funguria

1974 • 98 citations

Clinically Significant Mucosal Candidiasis Resistant to Fluconazole Treatment in Patients with AIDS

1994 • 98 citations

Azole resistance in Candida albicans.

1986 • 97 citations

Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans

1993 • 97 citations

Modulation of Host Defenses by Cytokines: Evolving Adjuncts in Prevention and Treatment of Serious Infections in Immunocompromised Hosts

1992 • 96 citations

In Vitro Studies of 5-Fluorocytosine Resistance in Candida albicans and Torulopsis glabrata

1972 • 94 citations

In vitro activity of itraconazole against fluconazole-susceptible and -resistant Candida albicans isolates from oral cavities of patients infected with human immunodeficiency virus

1994 • 90 citations

The Genetic Basis of Resistance to 5-Fluorocytosine inCandidaSpecies andCryptococcus Neoformans

1987 • 90 citations

In-vitro resistance to imidazole antifungals in Candida albicans

1984 • 89 citations

Cross-resistance to polyene and azole drugs in Cryptococcus neoformans

1995 • 87 citations

The lipid composition and permeability to azole of an azole- and polyene-resistant mutant ofCandida albicans

1987 • 81 citations

Fungal virulence genes as targets for antifungal chemotherapy

1996 • 80 citations

Correlation of in-vitro susceptibility test results with clinical response: a study of azole therapy in AIDS patients

1995 • 78 citations

Susceptibility testing of fungi: current status of the standardization process

1993 • 74 citations

Sterol content and polyene antibiotic resistance in isolates of Candida krusei, Candida parakrusei, and Candida tropicalis

1977 • 71 citations

Correlation of In Vitro Azole Susceptibility with In Vivo Response in a Murine Model of Cryptococcal Meningitis

1993 • 71 citations

Development of Resistance to 5-Fluorocytosine in Candida parapsilosis during Therapy

1974 • 71 citations

A Comparative Review of Colony-Stimulating Factors

1997 • 68 citations

The Genetics of Medically Important Fungi

1987 • 67 citations

Reduced virulence of Candida albicans mutants affected in multidrug resistance

1995 • 66 citations

Development of amphotericin B-resistant Candida tropicalis in a patient with defective leukocyte function

1978 • 60 citations

Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance

1996 • 60 citations

Oropharyngeal yeast flora and fluconazole resistance in HIV-infected patientsreceiving long-term continuous versus intermitent fluconazole therapy

1996 • 56 citations

Azole resistance in oropharyngeal Candida albicans strains isolated from patients infected with human immunodeficiency virus

1994 • 53 citations

Candida albicans resistance to 5-fluorocytosine: frequency of partially resistant strains among clinical isolates

1982 • 53 citations

Patterns of Fluconazole Susceptibility in Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis Due to Candida albicans

1997 • 51 citations

Antifungal prophylaxis with low-dose fluconazole during bone marrow transplantation. The Bone Marrow Transplantation Team.

1994 • 50 citations

Treatment of acyclovir-resistant herpes simplex virus infections in patients with AIDS.

1992 • 49 citations

Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo

1992 • 49 citations

Foscarnet treatment of cytomegalovirus gastrointestinal infections in acquired immunodeficiency syndrome patients who have failed ganciclovir induction.

1993 • 48 citations

Correlation between antifungal susceptibility testing ofCandida isolates from patients with HIV infection and clinical results after treatment with fluconazole

1994 • 46 citations

Topical Pharmacology of Imidazole Antifungals

1976 • 45 citations

5-Fluorocytosine resistance in Candida spp. and Torulopsis glabrata

1973 • 43 citations

Uptake of itraconazole by alveolar macrophages

1993 • 35 citations

Special Article: René Dubos: A Harbinger of Microbial Resistance to Antibiotics

1996 • 33 citations

Is there a correlation between serum antifungal drug concentration and clinical outcome?

1994 • 30 citations

<i>Candida</i><i>glabrata</i>, <i>Candida</i><i>krusei</i>, Non-albicans <i>Candida</i> spp., and Other Fungal Organisms in a Sixty-Bed National Cancer Center in 1989-1993: No Association with the Use of Fluconazole

1995 • 30 citations

Selection ofCandida Glabratain Pediatric Bone Marrow Transplant Recipients Receiving Fluconazole

1994 • 22 citations

DEVELOPMENT OF STRAINS OF CRYPTOCOCCUS NEOFORMANS RESISTANT TO NYSTATIN, AMPHOTERICIN B, TRICHOMYCIN AND POLYMYXIN B

1968 • 20 citations

Comparative morphological and biological studies on the itraconazole- and ketoconazole-resistant mutants ofCryptococcus neoformans

1990 • 17 citations

Fungal Infections and the Search for Novel Antifungal Agents

1988 • 16 citations

[Zidovudine-resistant HIV strains in intravenous drug users and homosexual men in Amsterdam].

1996 • 5 citations

Cytomegalovirus encephalitis resistant to anti-cytomegalovirus therapy.

1995 • 2 citations