Navigating the ClpB channel to solution

Protein folding and misfolding

2003 • 4,484 citations

Macromolecular crowding: obvious but underappreciated

2001 • 2,198 citations

Hsp104, Hsp70, and Hsp40

1998 • 1,346 citations

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

HSP104 Required for Induced Thermotolerance

1990 • 822 citations

Heat Shock Protein 101 Plays a Crucial Role in Thermotolerance in Arabidopsis

2000 • 666 citations

Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB

1999 • 587 citations

Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

1999 • 578 citations

Thermotolerance Requires Refolding of Aggregated Proteins by Substrate Translocation through the Central Pore of ClpB

2004 • 471 citations

Hsp104 Catalyzes Formation and Elimination of Self-Replicating Sup35 Prion Conformers

2004 • 471 citations

Sculpting the Proteome with AAA+ Proteases and Disassembly Machines

2004 • 455 citations

The Structure of ClpB

2003 • 426 citations

ClpS, a Substrate Modulator of the ClpAP Machine

2002 • 285 citations

Roles of Individual Domains and Conserved Motifs of the AAA+ Chaperone ClpB in Oligomerization, ATP Hydrolysis, and Chaperone Activity

2003 • 240 citations

Evidence for an Unfolding/Threading Mechanism for Protein Disaggregation by Saccharomyces cerevisiae Hsp104

2004 • 237 citations

Crystal Structures of the HslVU Peptidase–ATPase Complex Reveal an ATP-Dependent Proteolysis Mechanism

2001 • 233 citations

Substrate recognition by the AAA+ chaperone ClpB

2004 • 225 citations

Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants

2002 • 179 citations

Characterization of a Trap Mutant of the AAA+ Chaperone ClpB

2003 • 157 citations

Communication between ClpX and ClpP during substrate processing and degradation

2004 • 148 citations

Successive and Synergistic Action of the Hsp70 and Hsp100 Chaperones in Protein Disaggregation

2004 • 142 citations

Defining a Pathway of Communication from the C-Terminal Peptide Binding Domain to the N-Terminal ATPase Domain in a AAA Protein

2002 • 123 citations

Dominant Gain-of-Function Mutations in Hsp104p Reveal Crucial Roles for the Middle Region

2004 • 108 citations

Increased ubiquitin-dependent degradation can replace the essential requirement for heat shock protein induction

2003 • 80 citations

A Chaperone Network for the Resolubilization of Protein Aggregates: Direct Interaction of ClpB and DnaK

2003 • 79 citations