Differential expression of DNA topoisomerase I gene between CPT-11 acquired-and native-resistant human pancreatic tumor cell lines: Detected by RNAPCR-based quantitation assay

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 • 855 citations

Transcription of the dystrophin gene in human muscle and non-muscle tissues

1988 • 733 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit.

1987 • 320 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.

1989 • 260 citations

Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.

1990 • 226 citations

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance

1991 • 168 citations

Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites

1991 • 144 citations

Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.

1990 • 143 citations

Effects of camptothecin on the breakage and repair of DNA during the cell cycle.

1973 • 140 citations

Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.

1990 • 133 citations

Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

1988 • 125 citations

Effects of camptothecin on RNA synthesis in leukemia L1210 cells

1971 • 94 citations

Characterization of a camptothecin-resistant human DNA topoisomerase I.

1988 • 82 citations

Regulation of Xenopus laevis DNA topoisomerase I activity by phosphorylation in vitro

1988 • 63 citations

Asynchronous regulation of mouse H-2D and beta-2 microglobulin RNA transcripts

1985 • 60 citations

Camptothecin inhibits macromolecular synthesis in mammalian cells but not in isolated mitochondria or lE. coli

1970 • 58 citations

Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin.

1992 • 50 citations

Establishment and Characterization of Human Pancreatic Cancer Cell Lines in Tissue Culture and in Nude Mice

1990 • 44 citations

Pancreastatin producing cell line from human pancreatic islet cell tumor

1990 • 21 citations