Synthetic “interface” peptides alter dimeric assembly of the HIV 1 and 2 proteases

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

1994 • 3,007 citations

Enzyme Kinetics Behavior and analysis of rapid equilibrium and steady state enzyme systems

1975 • 1,447 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

1989 • 1,155 citations

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1989 • 883 citations

[3] Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance

1989 • 455 citations

VIRAL PROTEINASES

1988 • 448 citations

Crystal structure of a retroviral protease proves relationship to aspartic protease family

1989 • 345 citations

Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

1990 • 252 citations

Specific inhibition of herpesvirus ribonucleotide reductase by synthetic peptides

1986 • 201 citations

Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity.

1991 • 190 citations

Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide

1991 • 150 citations

Substrate analog inhibition and active site titration of purified recombinant HIV-1 protease

1990 • 127 citations

Stability and activity of human immunodeficiency virus protease: comparison of the natural dimer with a homologous, single-chain tethered dimer.

1990 • 119 citations

Structure of ethanol-inhibited porcine pepsin at 2-A resolution and binding of the methyl ester of phenylalanyl-diiodotyrosine to the enzyme.

1984 • 109 citations

Comparison of the crystal structures and intersubunit interactions of human immunodeficiency and Rous sarcoma virus proteases.

1990 • 104 citations

Comparative analysis of the sequences and structures of HIV‐1 and HIV‐2 proteases

1991 • 103 citations

Characterization of an active single polypeptide form of the human immunodeficiency virus type 1 protease.

1990 • 68 citations

Inhibition of HIV protease activity by heterodimer formation

1991 • 65 citations

Oligopeptides inhibit the ribonucleotide reductase of herpes simplex virus by causing subunit separation

1988 • 65 citations

Affinity purification of the HIV-1 protease

1989 • 58 citations

Interference with the assembly of a virus-host transcription complex by peptide competition

1990 • 46 citations

Activity and dimerization of human immunodeficiency virus protease as a function of solvent composition and enzyme concentration.

1992 • 46 citations

Organization of the sindbis virus nucleocapsid as revealed by bifunctional cross-linking agents

1987 • 38 citations

Recombinant HIV2 protease processes HIV1 Pr53gag and analogous junction peptides in vitro.

1990 • 32 citations

Human immunodeficiency virus type 1 and type 2 protease monomers are functionally interchangeable in the dimeric enzymes

1992 • 12 citations