The Hepatic Sinusoid in Aging and Cirrhosis

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1977 • 753 citations

The Liver Sieve: Considerations Concerning the Structure and Function of Endothelial Fenestrae, the Sinusoidal Wall and the Space of Disse

1985 • 689 citations

Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review

2002 • 676 citations

Capillarization of Hepatic Sinusoids in Man

1963 • 604 citations

Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions*

1997 • 400 citations

A linear method for determining liver sinusoidal and extravascular volumes

1963 • 397 citations

On the Uptake of Materials by the Intact Liver. THE TRANSPORT AND NET REMOVAL OF GALACTOSE

1973 • 295 citations

The Aging Liver

1998 • 290 citations

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations

1986 • 256 citations

Liver Function and Phase I Drug Metabolism in the Elderly

2001 • 236 citations

Lipoproteins and the liver sieve: The role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis

1995 • 230 citations

Liver Blood Flow

1981 • 224 citations

Effects of Liver Disease on Pharmacokinetics

1999 • 224 citations

Clinical Pharmacokinetic and Pharmacodynamic Considerations in Patients with Liver Disease

1995 • 200 citations

Pseudocapillarization and associated energy limitation in the aged rat liver

2001 • 195 citations

Alcoholic liver injury: Defenestration in noncirrhotic livers—a scanning electron microscopic study

1987 • 178 citations

Clinical Pharmacokinetics of Anxiolytics and Hypnotics in the Elderly

1991 • 177 citations

Clinical Pharmacokinetics of Anxiolytics and Hypnotics in the Elderly

1991 • 175 citations

Age-related pseudocapillarization of the human liver

2003 • 154 citations

Transendothelial Transport: The Vesicle Controversy

2002 • 152 citations

Postprandial lipoproteins and atherosclerosis

2001 • 149 citations

Clinical Pharmacokinetics in Patients with Liver Disease

1991 • 147 citations

Assessment of liver microcirculation in human cirrhosis.

1982 • 143 citations

Hepatic pseudocapillarisation and atherosclerosis in ageing

2002 • 140 citations

Hepatic microcirculation in the perfused cirrhotic rat liver.

1985 • 140 citations

Age-Related Changes in Liver Size and Hepatic Blood Flow

1988 • 137 citations

Aging and the liver.

1986 • 125 citations

Hypoxia and drug metabolism

1981 • 122 citations

Intact hepatocyte theory of impaired drug metabolism in experimental cirrhosis in the rat

1979 • 120 citations

Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis

1993 • 116 citations

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

1986 • 115 citations

Propranolol Disposition in Chronic Liver Disease

1976 • 102 citations

Hepatic sinusoidal pseudocapillarization with aging in the non-human primate

2003 • 92 citations

Evaluation of the Effect of Age on Functioning Hepatocyte Mass and Liver Blood Flow Using Liver Scintigraphy in Preoperative Estimations for Surgical Patients: Comparison with CT Volumetry

2002 • 90 citations

The hepatic microcirculation in the isolated perfused human liver

1996 • 88 citations

On the mechanism of hepatic transendothelial passage of large liposomes

1999 • 84 citations

Filtration of chylomicrons by the liver may influence cholesterol metabolism and atherosclerosis

1978 • 83 citations

High perfusion pressure damages the sieving ability of sinusoidal endothelium in rat livers.

1980 • 78 citations

THE EFFECT OF DIETARY FAT LOAD ON THE SIZE AND COMPOSITION OF CHYLOMICRONS IN THORACIC DUCT LYMPH

1968 • 73 citations

Uptake of materials by the intact liver. The exchange of glucose across the cell membranes.

1974 • 72 citations

Age-Environment and Gene-Environment Interactions in the Pathogenesis of Parkinson's Disease

2002 • 64 citations

The Role of the Sinusoidal Endothelium in Liver Function

1999 • 64 citations

Cationic Drug Pharmacokinetics in Diseased Livers Determined by Fibrosis Index, Hepatic Protein Content, Microsomal Activity, and Nature of Drug

2002 • 59 citations

Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver

1992 • 57 citations

Zonal heterogeneity of rat hepatocytes in the in vivo uptake of 17 nm colloidal gold granules

1985 • 56 citations

DEFENESTRATION OF HEPATIC SINUSOIDS AS A CAUSE OF HYPERLIPOPROTEINAEMIA IN ALCOHOLICS

1988 • 54 citations

Receptor measurements via Tc-GSA kinetic modeling are proportional to functional hepatocellular mass.

2001 • 53 citations

Limitations of tracer oxygen uptake in the canine coronary circulation.

1985 • 44 citations

Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple-indicator dilution technique

1993 • 42 citations

Comparative effects of oxygen supplementation on theophylline and acetaminophen clearance in human cirrhosis

1999 • 41 citations

Therapeutic implications of impaired hepatic oxygen diffusion in chronic liver disease

1991 • 40 citations

Hepatic Circulation in Cirrhosis

1985 • 37 citations

Hepatic artery flow and propranolol metabolism in perfused cirrhotic rat liver.

1999 • 36 citations

Oxygen supplementation restores theophylline clearance to normal in cirrhotic rats

1995 • 35 citations

31P and1H NMR spectroscopic studies of liver extracts of carbon tetrachloride-treated rats

1999 • 33 citations

Assessment of the hepatic circulation in humans: New concepts based on evidence derived from a D-sorbitol clearance method

1998 • 33 citations

Transport, binding, and metabolism of sulfate conjugates in the liver

1994 • 31 citations

Nicotine decreases the porosity of the rat liver sieve: a possible mechanism for hypercholesterolaemia.

1988 • 31 citations

Determination of a New 5-Lipoxygenase Inhibitor, Zileuton, and its Inactive N-Dehydroxylated Metabolite in Plasma by High Performance Liquid Chromatography

1995 • 29 citations

THE TRANSPORT OF CHOLESTEROL IN THORACIC DUCT LYMPH OF ANIMALS FED CHOLESTEROL WITH VARYING TRIGLYCERIDE LOADS

1969 • 28 citations

Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat

1993 • 28 citations

Dynamic computed tomography with low- and high-molecular-mass contrast agents to assess microvascular permeability modifications in a model of liver fibrosis

2002 • 27 citations

THE EFFECTS OF AGING AND NUTRITIONAL STATE ON HYPOXIA-REOXYGENATION INJURY IN THE PERFUSED RAT LIVER

1994 • 27 citations

Increased sensitivity of propranolol clearance to reduced oxygen delivery in the isolated perfused cirrhotic rat liver

1996 • 26 citations

Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver

2002 • 26 citations

Macromolecule transfer through mesothelium and connective tissue

2000 • 25 citations

HEPATIC MICROCIRCULATION OF LIVER CIRRHOSIS STUDIED BY CORROSION CAST/SCANNING ELECTRON MICROSCOPE EXAMINATION

1986 • 22 citations

Hydrodynamic effects on the solute transport across endothelial pores and hepatocyte membranes

2000 • 21 citations

Carbon Monoxide Disposition and Permeability-Surface Area Product in the Foetal Circulation of the Perfused Term Human Placenta

2002 • 20 citations

Acute oxygen supplementation restores markers of hepatocyte energy status and hypoxia in cirrhotic rats.

2000 • 20 citations

Hepatobiliary function in senescent male sprague-dawley rats

1994 • 18 citations

Flow-limited tracer oxygen distribution in the isolated perfused rat liver: Effects of temperature and hematocrit

1992 • 17 citations

Pathways of interstitial fluid and lymph flow in the liver acinus of the sheep and mouse

1998 • 17 citations

Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 2. Hemodynamic and drug disposition studies

1996 • 16 citations

Altered hepatobiliary transport of taurocholic acid in aged rats

1980 • 16 citations

Aging, acute oxidative injury and hepatocellular glucose transport in the rat

1995 • 16 citations

Structure–Hepatic Disposition Relationships for Phenolic Compounds

1999 • 15 citations

Interpretation of simultaneous measurements of hepatic extraction fractions of indocyanine green and sorbitol: evidence of hepatic shunts and capillarization?

2000 • 15 citations

Binding of Apolipoprotein E-Rich Remnant Lipoproteins to Human Liver Membranes

1984 • 15 citations

Drug Acetylation in Liver Disease

1998 • 14 citations

The modeling of tracer exchange and sequestration in the liver.

1984 • 11 citations

Carbon monoxide wash-in method to determine gas transfer in vascular beds: application to rat hindlimb

2001 • 10 citations

Carbon monoxide disposition in the perfused rat liver

1999 • 10 citations

Effect of cirrhosis on sulphation by the isolated perfused rat liver

1999 • 9 citations

Aging and the response of the isolated perfused rat liver to vasoactive drugs

1992 • 7 citations

Role of sinusoidal endothelial cells in liver disease

1995 • 6 citations

Vascular permeability in blood capillary

2002 • 6 citations