Cell-specific regulation of apoptosis by designed enediynes.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Shigella flexneri induces apoptosis in infected macrophages

1992 • 1,130 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity

1989 • 689 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation.

1990 • 485 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation.

1991 • 429 citations

Designed Enediynes: A New Class of DNA-Cleaving Molecules with Potent and Selective Anticancer Activity

1992 • 318 citations

Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism.

1989 • 298 citations

Evaluation of glucocorticoid‐induced DNA fragmentation in mouse thymocytes by flow cytometry

1991 • 241 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.

1990 • 185 citations

DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores.

1990 • 154 citations

Cleavage behavior of calicheamicin gamma 1 and calicheamicin T.

1992 • 132 citations

The effects of testosterone, 5α-dihydrotestosterone and adenosine 3′,5′-monophosphate on cell proliferation and differentiation in RAT prostate

1973 • 115 citations

Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents

1991 • 115 citations

Regression of nitrosamine-induced pancreatic cancers in hamsters treated with luteinizing hormone-releasing hormone antagonists or agonists.

1990 • 49 citations

Influence of thiol structure on neocarzinostatin activation and expression of DNA damage

1992 • 43 citations

[Lessons derived from the use of the artificial kidney for the interpretation of electrolytic disorders of acute uremia].

1956 • 15 citations

Heat-induced DNA cleavage by esperamicin antitumor antibiotics

1991 • 12 citations