Fas-induced Arachidonic Acid Release Is Mediated by Ca2+-independent Phospholipase A2 but Not Cytosolic Phospholipase A2, Which Undergoes Proteolytic Inactivation

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Microdetermination of Long-chain Fatty Acids in Plasma and Tissues

1960 • 2,233 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

Properties and Regulation of Cytosolic Phospholipase A2

1997 • 814 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

A License to Kill

1996 • 649 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum

1995 • 469 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

1993 • 424 citations

Inhibition of Macrophage Ca2+-independent Phospholipase A2 by Bromoenol Lactone and Trifluoromethyl Ketones

1995 • 401 citations

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

1998 • 369 citations

Mammalian non-pancreatic phospholipases A2

1993 • 355 citations

Translocation of the 85-kDa Phospholipase A2 from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen

1995 • 331 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

Function and Inhibition of Intracellular Calcium-independent Phospholipase A2

1997 • 306 citations

A Novel Cytosolic Calcium-independent Phospholipase A2 Contains Eight Ankyrin Motifs

1997 • 302 citations

Novel Group V Phospholipase A2 Involved in Arachidonic Acid Mobilization in Murine P388D1 Macrophages

1996 • 259 citations

Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor

1993 • 253 citations

Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.

1989 • 242 citations

Antisense Inhibition of Group VI Ca2+-independent Phospholipase A2 Blocks Phospholipid Fatty Acid Remodeling in Murine P388D1 Macrophages

1997 • 221 citations

Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2

1995 • 216 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Involvement of caspase-dependent activation of cytosolic phospholipase A₂in tumor necrosis factor-induced apoptosis

1997 • 207 citations

Cytosolic Phospholipase A2 Is Required for Cytokine-induced Expression of Type IIA Secretory Phospholipase A2 That Mediates Optimal Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Rat 3Y1 Fibroblasts

1998 • 190 citations

Segregated Coupling of Phospholipases A2, Cyclooxygenases, and Terminal Prostanoid Synthases in Different Phases of Prostanoid Biosynthesis in Rat Peritoneal Macrophages

1998 • 179 citations

MADD, a Novel Death Domain Protein That Interacts with the Type 1 Tumor Necrosis Factor Receptor and Activates Mitogen-activated Protein Kinase

1997 • 164 citations

Analysis of the Secretory Phospholipase A2 That Mediates Prostaglandin Production in Mast Cells

1997 • 164 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Cytosolic Phospholipase A2 (PLA2), but Not Secretory PLA2, Potentiates Hydrogen Peroxide Cytotoxicity in Kidney Epithelial Cells

1996 • 135 citations

Type II Secretory Phospholipase A2 Associated with Cell Surfaces via C-terminal Heparin-binding Lysine Residues Augments Stimulus-initiated Delayed Prostaglandin Generation

1996 • 133 citations

Activation of intracellular proteases is an early event in TNF-induced apoptosis.

1995 • 129 citations

Prostaglandin E2 Amplifies Cytosolic Phospholipase A2- and Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Mouse Osteoblastic Cells

1997 • 123 citations

Suppression of monocyte 85-kDa phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis

1994 • 116 citations

Identification of Essential Residues for the Catalytic Function of 85-kDa Cytosolic Phospholipase A2

1996 • 112 citations

The perturbed membrane of cells undergoing apoptosis is susceptible to type II secretory phospholipase A2 to liberate arachidonic acid

1997 • 104 citations

Apoptosis: alive and kicking in 1997

1997 • 104 citations

Relationship between Arachidonate−Phospholipid Remodeling and Apoptosis

1996 • 97 citations

Susceptibility to TNF in the presence of inhibitors of transcription or translation is dependent on the activity of cytosolic phospholipase A2 in human melanoma tumor cells.

1996 • 72 citations

Different Apoptotic Pathways Mediated by Fas and the Tumor‐Necrosis‐Factor Receptor

1996 • 53 citations

Thrombin produces phosphorylation of cytosolic phospholipase A2 by a mitogen-activated protein kinase kinase-independent mechanism in the human astrocytoma cell line 1321N1

1997 • 37 citations

Contribution of pH‐dependent group II phospholipase A2 to chemical hypoxic injury in rat hepatocytes

1996 • 30 citations