Prostaglandin E2 Amplifies Cytosolic Phospholipase A2- and Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Mouse Osteoblastic Cells

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

1995 • 1,133 citations

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 • 1,102 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

1993 • 424 citations

Distinct Roles in Signal Transduction for Each of the Phospholipase A2 Enzymes Present in P388D1 Macrophages

1996 • 355 citations

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

1993 • 348 citations

A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains

1995 • 327 citations

Cloning and expression of a membrane receptor for secretory phospholipases A2.

1994 • 278 citations

Novel Group V Phospholipase A2 Involved in Arachidonic Acid Mobilization in Murine P388D1 Macrophages

1996 • 259 citations

Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression

1991 • 253 citations

Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages.

1994 • 243 citations

Interleukin-1 alpha induces the accumulation of cytosolic phospholipase A2 and the release of prostaglandin E2 in human fibroblasts.

1992 • 230 citations

Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells.

1994 • 219 citations

Molecular nature of phospholipases A2 involved in prostaglandin I2 synthesis in human umbilical vein endothelial cells. Possible participation of cytosolic and extracellular type II phospholipases A2.

1993 • 210 citations

Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis.

1993 • 208 citations

Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.

1993 • 206 citations

Identification of Phosphorylation Sites of Human 85-kDa Cytosolic Phospholipase A2 Expressed in Insect Cells and Present in Human Monocytes

1996 • 165 citations

Analysis of the Secretory Phospholipase A2 That Mediates Prostaglandin Production in Mast Cells

1997 • 164 citations

Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells.

1993 • 155 citations

c-Kit Ligand Mediates Increased Expression of Cytosolic Phospholipase A2, Prostaglandin Endoperoxide Synthase-1, and Hematopoietic Prostaglandin D2 Synthase and Increased IgE-dependent Prostaglandin D2 Generation in Immature Mouse Mast Cells

1995 • 149 citations

Type II Secretory Phospholipase A2 Associated with Cell Surfaces via C-terminal Heparin-binding Lysine Residues Augments Stimulus-initiated Delayed Prostaglandin Generation

1996 • 133 citations

Activation of Cytosolic Phospholipase A2 by Platelet-derived Growth Factor Is Essential for Cyclooxygenase-2-dependent Prostaglandin E2 Synthesis in Mouse Osteoblasts Cultured with Interleukin-1

1997 • 118 citations

Suppression of monocyte 85-kDa phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis

1994 • 116 citations

Selective Inhibition of Prostaglandin Endoperoxide Synthase-1 (Cyclooxygenase-1) by Valerylsalicylic Acid

1995 • 112 citations

Interleukin-3 Regulates Development of the 5-Lipoxygenase/Leukotriene C4 Synthase Pathway in Mouse Mast Cells

1995 • 107 citations

Interferon-gamma induces the synthesis and activation of cytosolic phospholipase A2.

1994 • 88 citations

IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2.

1995 • 87 citations

Functional Identification of the Active-Site Nucleophile of the Human 85-kDa Cytosolic Phospholipase A₂

1996 • 85 citations

Release of 14‐kDa group‐II phospholipase A₂ from activated mast cells and its possible involvement in the regulation of the degranulation process

1992 • 82 citations

Secretory phospholipases A2

1995 • 79 citations

Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site.

1993 • 67 citations

Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways

1994 • 62 citations

Exacerbation of rat adjuvant arthritis by intradermal injection of purified mammalian 14‐kDa group II phospholipase A₂

1990 • 55 citations

Antiinflammatory action of thielocin A1?, a group II phospholipase A2 specific inhibitor, in rat carrageenan-induced pleurisy

1993 • 29 citations

Type II Phospholipase A2Is Linked to Cyclooxygenase-2-Mediated Delayed Prostaglandin D2Generation by Cultured Mouse Mast Cells Following FcϵRI- and Cytokine-Dependent Activation

1996 • 19 citations

Arachidonic Acid Up‐Regulates and Prostaglandin E₂ Down‐Regulates the Expression of Pancreatic‐Type Phospholipase A₂ and Prostaglandin‐Endoperoxide Synthase 2 in Uterine Stromal Cells

1996 • 11 citations