Thioredoxin Peroxidase (Natural Killer Enhancing Factor) Regulation of Activator Protein-1 Function in Endothelial Cells

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.

1994 • 743 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α

1998 • 672 citations

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

1997 • 372 citations

Tumor Necrosis Factor ä-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways

1997 • 355 citations

Age-related Decline in Mitogen-activated Protein Kinase Activity in Epidermal Growth Factor-stimulated Rat Hepatocytes

1996 • 351 citations

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1994 • 294 citations

Involvement of the Transcription Factor NF-κB in Tubular Morphogenesis of Human Microvascular Endothelial Cells by Oxidative Stress

1996 • 278 citations

転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

Cyclic Strain–Induced Monocyte Chemotactic Protein-1 Gene Expression in Endothelial Cells Involves Reactive Oxygen Species Activation of Activator Protein 1

1997 • 246 citations

Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells.

1997 • 183 citations

Transcriptional Activation of the HO-1 Gene by Lipopolysaccharide Is Mediated by 5 ′ Distal Enhancers: Role of Reactive Oxygen Intermediates and AP-1

1998 • 127 citations

Inhibition of AP-1 DNA Binding by Nitric Oxide Involving Conserved Cysteine Residues in Jun and Fos

1998 • 119 citations

Specific cleavage of transcription factors by the thiol protease, m-calpain

1993 • 99 citations

Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun.

1993 • 98 citations

Antioxidant Function of Recombinant Human Natural Killer Enhancing Factor

1995 • 79 citations

Thioredoxin-Linked Peroxidase from Human Red Blood Cell: Evidence for the Existence of Thioredoxin and Thioredoxin Reductase in Human Red Blood Cell

1995 • 76 citations

Hydrogen peroxide-induced expression of the proto-oncogenes, c-jun, c-fos and c-myc in rabbit lens epithelial cells.

1997 • 72 citations

Differential sensitivity of FOS and JUN family members to calpains.

1994 • 69 citations

Endogenous Natural Killer Enhancing Factor-B Increases Cellular Resistance to Oxidative Stresses

1997 • 63 citations

Recombinant natural killer enhancing factor augments natural killer cytotoxicity

1996 • 54 citations

Characterization of Antioxidant Properties of Natural Killer-Enhancing Factor-B and Induction of Its Expression by Hydrogen Peroxide

1997 • 44 citations

Mutation of a phosphorylation site in the DNA-binding domain is required for redox-independent transactivation of AP1-dependent genes by v-Jun.

1993 • 29 citations

Cellular Antioxidant Properties of Human Natural Killer Enhancing Factor B

1997 • 26 citations